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Palonosetron powder for injection and its preparing method

A technology of palonosetron and powder injection, applied in the field of palonosetron powder injection and its preparation, which can solve the problems of limiting treatment dose and course of treatment, affecting the quality of life of patients, and endangering life

Inactive Publication Date: 2006-08-09
孟繁浩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The adverse reactions of chemotherapy can temporarily or long-term affect the quality of life of patients, which may limit the dose and course of treatment, and even endanger life in severe cases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Component Weight (1000 pieces)

[0012] Palonosetron 250mg

[0013] Hydrochloric acid amount

[0014] Mannitol 200g

[0015] Water for injection 1000ml

[0016] Preparation:

[0017] Under clean conditions, take the prescribed amount of panosetron raw material, add an appropriate amount of water for injection, add appropriate amount of hydrochloric acid under stirring to completely dissolve the panosetron, add the prescribed amount of mannitol, adjust the pH value to 4.5-5.5, and then add water for injection to the full amount. Filter, freeze-dry according to the freeze-dried powder injection process, and make palonosetron powder injection with a specification of 0.25 mg / support.

Embodiment 2

[0019] Component Weight (1000 pieces)

[0020] Palonosetron 250mg

[0021] Amount of sulfuric acid

[0022] Lactose 300g

[0023] Water for injection 1000ml

[0024] Preparation:

[0025] Under clean conditions, take the prescribed amount of panosetron raw material, add an appropriate amount of water for injection, add an appropriate amount of sulfuric acid under stirring to completely dissolve the panosetron, add the prescribed amount of lactose, adjust the pH value to 5.0-7.0, and use it with a small amount of needle Activated carbon treatment, and then add water for injection to the full amount. Filter, freeze-dry according to the freeze-dried powder injection process, and make palonosetron powder injection with a specification of 0.25 mg / support.

Embodiment 3

[0027] Component Weight (1000 pieces)

[0028] Palonosetron 250mg

[0029] Citric acid amount

[0030] Lactose 300g

[0031] Water for injection 1000ml

[0032] Preparation:

[0033] Under clean conditions, take the prescribed amount of panosetron raw material, add an appropriate amount of water for injection, add an appropriate amount of citric acid under stirring to completely dissolve the panosetron, add the prescribed amount of lactose, adjust the pH value to 5.0-7.0, and use a small amount of The needle was treated with activated carbon, and then filled with water for injection to the full amount. Filter, freeze-dry according to the freeze-dried powder injection process, and make palonosetron powder injection with a specification of 0.25 mg / support.

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PUM

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Abstract

The present invention relates to a powder injection containing panorsqiong and its preparation method. It is made up by using panorsqiong or its salt (panorsqiong hydrochloride) and medicinal auxiliary material through a certain preparation process. Its product quality is stable.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to palonosetron powder injection and a preparation method thereof. Background technique [0002] With the improvement of the status of chemotherapy in tumor treatment and the application of more and more new chemotherapy drugs, people have a deeper understanding of the adverse reactions of chemotherapy. The adverse reactions of chemotherapy can temporarily or long-term affect the quality of life of patients, may limit the dose and course of treatment, and even endanger life in severe cases. In recent years, the development of chemotherapy adjuvant drugs has made great contributions to the improvement of chemotherapy efficacy and the reduction of adverse reactions. Nausea and vomiting caused by chemotherapy are the most feared adverse reactions of cancer patients. Insufficient control of nausea and vomiting will produce a series of related complications. Severe nausea ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4725A61K9/14A61K9/16A61P1/08
Inventor 孟繁浩
Owner 孟繁浩
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