Dral solid formulation and its preparing method

A solid preparation, Liushen pill technology, applied in the directions of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of slow disintegration and absorption, low bioavailability, slow onset of action, etc., and achieve rapid disintegration. , high bioavailability, fast onset effect

Inactive Publication Date: 2006-08-09
雷允上药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because Liushen Pill is a traditional pill, it has the disadvantages of slow disintegration and absorption, slow onset of action, and low bioavailability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033] Prescription: Liushen Pills 31.25g

[0034] Starch 63.75g

[0035] Sodium starch glycolate 4.5g

[0036] Magnesium stearate 0.5g

[0037] Makes 1000 pieces

[0038] Preparation method: Take an appropriate amount of starch to make 5% starch slurry by the usual method, mix the remaining starch with carboxymethyl starch sodium and pass through a 200-mesh sieve, mix with Liushen Wan fine powder, granulate with 5% starch slurry, and dry at 60-70°C , whole grains, added magnesium stearate, mixed evenly, pressed into tablets, coated with sugar to obtain Liushen Tablets.

example 2

[0040] Prescription: Liushen Wan Powder 10.4g

[0041] Lactose 38.6g

[0042] Microcrystalline Cellulose 35g

[0043] 10g pregelatinized starch

[0044] Polyvinylpyrrolidone 5g

[0045] Magnesium Stearate 1g

[0046]Makes 1000 pieces

[0047] Preparation method: mix Liushen Wan powder with lactose, microcrystalline cellulose, pregelatinized starch, polyvinylpyrrolidone, and magnesium stearate, and press into tablets to obtain Liushen tablets.

example 3

[0049] Prescription: Liushen Wan Powder 10.4g

[0050] Dextrin 117.6g

[0051] Low-substituted hydroxypropyl cellulose 10g

[0052] Polyvinylpyrrolidone 10g

[0053] Micronized silica gel 2g

[0054] Makes 1000 pieces

[0055] Preparation method: Mix Liushen Wan powder, dextrin, and low-substituted hydroxypropyl cellulose through an 80-mesh sieve, granulate with 5% polyvinylpyrrolidone and ethanol, dry at 60°C, granulate, add micropowder silica gel, mix evenly, and press Tablets, film-coated to obtain Liushen Tablets.

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Abstract

The present invention discloses a kind of six spirits oral solid preparation, including six spirits tablet preparation and six spirits capsule preparation (hard capsule preparation and soft capsule preparation). Its tablet core or capsule contents can be made up by using 0.5-80% of six spirits pill powder and 20-99.5% of auxiliary material. It has the functions of clearing away heat and toxic material, relieving inflammation and stopping pain, can be used for mainly curing the diseases of sore-throat, laryngopharyngitis, acute throat trouble, tonsillitis, furuncle in children, large carbuncle, acute mastitis, innominate inflammatory swelling, and can obtain good therapeutic effect for curing the diseases of herpes zoster, phlebitis, leukemia, tumor in digestive tract and mammitis, etc.

Description

1. Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a class of Liushen oral solid preparation and a preparation method thereof. 2. Background technology [0002] Liushen Pill is a traditional Chinese medicine that has enjoyed a century-old reputation both at home and abroad. It is composed of six flavors of Chinese medicine such as musk. It has the effects of cooling and detoxifying, reducing inflammation and relieving pain. For rotten throat dansha, sore throat, throat wind and throat carbuncle, single and double breast moth, children's hot boil, carbuncle ulcer furuncle, milk carbuncle on the back, unknown swelling and poison. In addition, it also has a good therapeutic effect on herpes zoster, phlebitis, leukemia, digestive tract tumors, and mastitis. However, because Liushen Pill is a traditional pill, it has the disadvantages of slow disintegration and absorption, slow onset of action, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K35/413A61K31/045A61K33/36A61K35/55A61K9/20A61K9/48A61P11/04A61K35/618A61K35/65
Inventor 周一君朱卫宁刘东卢扬孙晓波陆荣
Owner 雷允上药业有限公司
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