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Method for extracting fat soluble component in Chinese medicine red sage root by subcritical water

A subcritical water, fat-soluble technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulations, plant/algae/fungus/moss components, etc., can solve the problems of harsh experimental conditions, decomposition of organic compounds, etc. short effect

Inactive Publication Date: 2006-08-23
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the harsh experimental conditions of supercritical water and the corrosiveness of supercritical water, some organic compounds will be decomposed, so it cannot be used as an extraction agent in the laboratory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 50 g of the traditional Chinese medicine Salvia miltiorrhiza is crushed into granules and loaded into an extraction kettle. Pump water into the extraction kettle through a high-pressure pump. The operating pressure of the extraction kettle is 10MPa, and at the same time, turn on the heating device of the jacket of the extraction kettle to 185°C. After 15 minutes of extraction, pump water into the extraction kettle through a high-pressure pump to replace the extract, and the high-temperature extract can be cooled to below 100°C through the cooling system. After cooling to normal temperature, quantitative analysis is carried out, and the extraction amount is 0.0021g Tanshinone II A / g Danshen.

Embodiment 2

[0020] 50 g of the traditional Chinese medicine Salvia miltiorrhiza is crushed into granules and loaded into an extraction kettle. Pour water into the extraction kettle through a high-pressure pump, and the operating pressure of the extraction kettle is 5MPa, and at the same time, turn on the heating device of the outer jacket of the extraction kettle to 150°C. After 5 minutes of extraction, pump water into the extraction kettle through a high-pressure pump to replace the extract, and the high-temperature extract can be cooled to below 100°C through the cooling system. After cooling to normal temperature, quantitative analysis is carried out, and the extraction amount is 0.0017g tanshinone II A / g Danshen.

Embodiment 3

[0022] 50 g of the traditional Chinese medicine Salvia miltiorrhiza is crushed into granules and loaded into an extraction kettle. Pour water into the extraction kettle through a high-pressure pump, and the operating pressure of the extraction kettle is 5MPa. At the same time, turn on the heating device of the jacket of the extraction kettle to 200°C. After 15 minutes of extraction, pump water into the extraction kettle through a high-pressure pump to replace the extract, and the high-temperature extract can be cooled to below 100°C through the cooling system. After cooling to normal temperature, quantitative analysis is carried out, and the extraction amount is 0.0018g tanshinone II A / g Danshen.

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Abstract

The present invention discloses method of extracting liposoluble component from Chinese medicine red sage. The extraction process includes crushing red sage into grains, feeding into extracting tank, pumping preheated water into the extracting tank, extracting at pressure of 5-30 MPa and temperature of 100-300 deg.c for 5-120 min, separation to obtain high temperature extract, and cooling to below 100 deg.c. The said process can obtain neotanshinone IIA and other liposoluble components. The present invention provides one process similar to decoction, has no need of organic solvent, advanced process, environment friendship, quick extraction speed, high efficiency and other advantages.

Description

technical field [0001] The invention relates to a method for extracting effective components of traditional Chinese medicine, in particular to a method for extracting fat-soluble components in the traditional Chinese medicine Salvia miltiorrhiza with subcritical water. Background technique [0002] Water is an extraction solvent that is harmless to the environment. The traditional Chinese method of boiling Chinese herbal medicine is to use water decoction. Under normal temperature and pressure, water is a very polar solvent, which can dissolve polar organic compounds very well, but has very little solubility for neutral polar and non-polar organic compounds. As the temperature increases, the polarity of water decreases and its ability to dissolve organic matter increases. Under moderate pressure, the water is heated to a high temperature above 100°C and below the critical temperature of 374°C. The water body remains in a liquid state, and its polarity will change with the t...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K125/00
Inventor 陈赟田景奎
Owner ZHEJIANG UNIV
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