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Medicinal composition containing tanshinone and its preparation process and usage

A composition and technology of tanshinone, applied in the field of emulsion and preparation thereof, can solve the problems of low central nervous system content, difficult to penetrate protein biofilm, low bioavailability, etc., and achieve less side effects, significant targeting, and stable quality Effect

Inactive Publication Date: 2006-10-04
海口绿科南药研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes how we tested different types of vegetable or animal fats like safflower oil compared against other substances called lanolin because they have lower melting points at room temperature making them easier to mix together without losing their properties during processing. By adjusting this ratio between certain ingredients, these triglycerides could become even stronger when combined with another type of fat instead of just one kind. These triglycostones were then added back onto top layers from synthetic resin compositions containing hydroxypropyl methacrylate copolyester elastomers. Overall, this new method provides technical benefits over existing methods while still providing stability and safety factors.

Problems solved by technology

This patented technical problem addressed by this patents relates to improving the effectiveness of extractives from Radix Bupleuris Linnoside Mats® which act like reducing plaque buildup caused by inflammable particles called phosphorus pentoxytranadionane ("PPT"), leading to better health outcomes such as improved heart function and prevention of lung disease associated with chronic obstructive airways syndrome.

Method used

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  • Medicinal composition containing tanshinone and its preparation process and usage
  • Medicinal composition containing tanshinone and its preparation process and usage

Examples

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Effect test

preparation example 1

[0025] Preparation Example 1: Preparation of Refined Tanshinone

[0026] Take Danshen medicinal material, pulverize, extract with 95% ethanol, recover ethanol to obtain extract, purify by silica gel column chromatography, and elute with petroleum ether-diethyl ether gradient, collect parts rich in refined tanshinone, and obtain refined tanshinone. As determined by high performance liquid phase (HPLC), it contains 56% (w / w) of refined tanshinone.

preparation example 2

[0027] Preparation Example 2: Preparation of Refined Tanshinone

[0028] The Danshen medicinal material is crushed and sieved, placed in a 5L supercritical extraction equipment, CO 2 Supercritical fluid extract (extraction tank 35MPa, 60 ℃, time 40min, 95% ethanol as entrainer, circulation volume is 675ml h -1 , that is, the dosage is 30% of the total medicinal material, the pressure is 5MPa, the temperature is 45°C, the salvia miltiorrhiza extract is filtered, the filtrate is left to stand, and the precipitate is collected, purified by silica gel column chromatography, petroleum ether-ether gradient elution, and the fraction rich in refined tanshinone is collected , to obtain refined tanshinone. As determined by high performance liquid phase (HPLC), it contains 89% (w / w) of refined tanshinone.

Embodiment 1

[0029] Embodiment 1: the preparation of refined tanshinone emulsion

[0030] Add 50 mg of refined tanshinone and 0.5 g of soybean lecithin to the mixed oil of 1.0 g of camellia oil and 4.0 g of medium-chain oil, add 0.02 g of sodium oleate, heat to 60-80 ° C, stir to dissolve into a clear solution, and obtain oil phase; dissolve 2.5g of glycerin in 20ml of water to form a water phase, heat to 60-80°C; add the oil phase containing refined tanshinone to the water phase and emulsify into colostrum with high-speed stirring, and add water to the volume of the obtained colostrum to 100ml , emulsified by a high-pressure homogenizer under the condition of a pressure of 100Mpa, and then sterilized at 121°C for 15 minutes after packaging to obtain an emulsion. The obtained emulsion is a uniform light orange yellow emulsion with an average particle diameter of 166nm.

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Abstract

Disclosed is a medicinal composition containing tanshinone and its preparing process, wherein the composition comprises tanshinone, oil, emulsifying agent and water. The composition can be prepared into oral administration emulsion or venous emulsion, and can be used for treating or preventing infection, cerebral apoplexy, cerebral ischemia / reperfusion injury, ischemic heart disease, tumor, liver fibrosis, diabetic complication, pulmonary fibrosis, chronic nephritis, chronic kidney functional insufficiency and Alzheimer's disease.

Description

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Claims

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Application Information

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Owner 海口绿科南药研究开发有限公司
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