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Diagnosis of risk of breast cancer

A breast cancer, risk technology, applied in areas at risk of existing or developing cancer, that can solve problems such as low diagnostic sensitivity and disease specificity

Inactive Publication Date: 2006-10-11
RANDOX LAB LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This is due to the low diagnostic sensitivity and disease specificity of established markers

Method used

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  • Diagnosis of risk of breast cancer
  • Diagnosis of risk of breast cancer

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Embodiment

[0047] Using non-isotopic differential display (DDRT-PCR), many differentially expressed gene fragments were isolated from cDNA populations from matched clinical samples of breast cancer patients. One of these fragments, referred to herein as DD11, was shown to be significantly upregulated in breast tumor tissue samples from a number of donors. This paper will detail the expression profile of this new molecular marker, its full length and corresponding deduced protein sequence.

[0048] Materials and methods

[0049] Differential gene expression was performed between normal breast tissue and tumor tissue pairs from the same donor. Tissue samples were obtained from Pathlore, Peterborough, UK, in full compliance with ethical requirements and with patient consent. After the tumor is surgically removed, a sample of tumor tissue is collected along with adjacent normal tissue that was removed together. Messenger RNA was extracted using Dynabeads labeled with Dynabeads and Supersc...

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Abstract

The present invention discloses a diagnostic method for predicting cancer risk, especially breast cancer risk. The method includes: (i) isolating a patient genome sample; (ii) detecting the presence or expression of a gene included in the sequence of SEQ ID NO. 1 of the present invention, wherein the presence or expression of the gene indicates the presence of cancer or the presence of cancer risks of.

Description

technical field [0001] The present invention relates to detecting the presence of or the risk of developing cancer, especially breast cancer. Background technique [0002] There are more than 1 million cases of breast cancer each year worldwide, with about 500,000 in the US, 40,000 in the UK and almost 2,000 in Ireland. It is the leading cause of cancer death in women. Although the incidence of the disease is increasing in the Western world, more extensive testing and improved treatment have led to a gradual decline in the mortality rate, which has dropped by about 1% per year since 1991. Patients diagnosed with early-stage breast cancer have a 5-year relative survival rate of more than 90%, while those diagnosed with distant metastases have a 5-year relative survival rate of only 20%. However, there is no authoritative early screening test for breast cancer and diagnosis is currently based on the results of mammography and fine needle biopsy. Mammography has its limitati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6886C12Q2600/158A61P35/00
Inventor M·A·克罗克德J·R·贝利J·V·拉蒙特S·P·菲茨杰拉德
Owner RANDOX LAB LTD
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