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Nephropathy treating medicine composition and its prepn process

A composition and medicine technology, applied in the field of pharmaceutical compositions for the treatment of kidney disease, can solve problems such as unseen, and achieve the effects of convenient administration, excellent social and economic benefits, and simple production process

Active Publication Date: 2006-10-18
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to the novelty investigation, among the traditional Chinese medicine formulas developed at home and abroad for the treatment of glomerular and tubulointerstitial lesions, there is no research on the preparation of pharmaceutical preparations made from the five traditional Chinese medicines of Bupleurum, Astragalus, Angelica, Chuanshanlong, and leech. to report

Method used

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  • Nephropathy treating medicine composition and its prepn process

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experiment example

[0021] Experimental Example Observe the curative effect of the combination extract of the present invention on treating glomerular and tubulointerstitial lesions.

[0022] One, the therapeutic effect observation of extract of the present invention on aminonucleoside puromycin (PAN) induced rat nephrotic syndrome companion focal segmental glomerulosclerosis:

[0023] Experimental Materials

[0024] Animals: animal Wistar rats, male, weighing 180-200g, class II animals.

[0025] drug:

[0026] (1) Test drug The extract of the present invention was dissolved in distilled water.

[0027] (2) Positive control drug Monroe Tablets (fosinopril sodium tablets), tablets, specifications: 10 mg / tablet, daily dosage for a person is 10 mg, produced by Sino-US Shanghai Bristol-Myers Squibb Pharmaceutical Co., Ltd., batch number: 0302086.

[0028] Reagent

[0029] Aminonucleoside puromycin (PAN) was purchased from Sigma, lot number: 22K4061.

[0030] instrument

[0031] Metabolic cage S...

Embodiment 1

[0275] Astragalus 503g Angelica 252g Pangosaurus 377g

[0276] Bupleurum 252g Leech 76g

[0277] Take astragalus and leech and add water to decoct three times, combine the decoction, and concentrate the filtrate to obtain a thick paste①. Danggui, Chuanshanlong and Bupleurum were soaked and extracted three times with 60% ethanol, soaked for 3 days, and combined the three extracts to obtain a thick ointment ②. Combine thick pastes ① and ②, mix well, dry in vacuum, and pulverize. Take the dry powder, add 1.4 times of dextrin, mix well, add 75% ethanol in an appropriate amount to granulate, dry, and make granules, take 8g orally once, twice a day.

Embodiment 2

[0279] Astragalus 450g, Angelica 200g, Pangosaurus 320g,

[0280] Bupleurum 200g, leech 60g.

[0281] Angelica, pangolin and Bupleurum were extracted 4 times with 90% ethanol, and concentrated to obtain a thick paste. Astragalus and leeches are decocted in water for 3 times, and the filtrate is concentrated to obtain a thick paste. Combine the above two thick pastes, dry to obtain dry powder, add appropriate amount of auxiliary materials, and make tablets. 2 times a day, 3 to 4 tablets each time.

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Abstract

The present invention discloses one kind of nephropathy treating medicine composition and its preparation process. The Chinese medicine composition is prepared with Nippon yam rhizome, bupleurum root, angelica, astragalus root and leech. It is used in treating mesenchymal disease of glomerulum and renaltubule, chronic glomerulonephritis, renal disease, nephritic syndrome, etc. It has determined curative effect.

Description

field of invention [0001] The invention relates to a pharmaceutical composition for treating nephropathy and a preparation method of the composition, in particular to a method for treating glomerular and tubulointerstitial lesions caused by various reasons: chronic glomerulonephritis, IgA nephropathy, Traditional Chinese medicine composition for nephrotic syndrome, chronic renal insufficiency, early azotemia and preparation method thereof. Background technique [0002] Chronic glomerular disease is a common and refractory clinical disease that is extremely harmful to human health. In my country, more than half of patients with chronic renal failure have chronic glomerular disease as their primary disease. Proteinuria is the most prominent clinical feature of chronic glomerular disease. Persistent proteinuria has a poor prognosis and often increases the mortality of patients with renal disease, which is a reflection of the severity of substantial renal disease. At present, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K35/10A61K35/62A61P13/12
Inventor 李平莫用元张红陈玉武赵世萍李克明郭景珍付桂香
Owner SHINEWAY PHARMA GRP LTD
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