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Bioimpedance methods and apparatus

A bio-impedance, resistor technology, used in sensors, medical science, diagnosis, etc., can solve problems such as impact

Inactive Publication Date: 2006-10-18
肾脏研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a recent study found that bioimpedance measurements performed at 50 kHz are affected when the test subjects have a large amount of adipose tissue [7]

Method used

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  • Bioimpedance methods and apparatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The experimental data of Example 1 were obtained by applying a current with a frequency of 5 kHz. Equivalent circuit models of the body segment components of the present invention are preferably used to describe the response to multi-frequency currents. Example 2 shows the results of this multiple frequency test. In particular, this example shows that subjects with different fat content differ in the resistance drop of their impedance as the frequency of the current increases.

[0084] Figure 2B yes Figure 2A An improved version of the equivalent circuit model. Figure 2B Middle, Z 总 Represents the total impedance measured at the two electrodes A and B. Such as Figure 2A Same, R S , R F , R E , R I and R B represent the electrical resistance of skin, fat, extracellular and intracellular volume, and bone, respectively, C IN 、C F and ℃ M represent the capacitance between the skin and the electrode, the capacitance of the fat mass, and the capacitance of t...

Embodiment 2

[0145] Multiple frequency analysis

[0146] In order to improve the existing BIS technology, a correct electrical model should be able to explain the electrical properties of different proportions of body tissue under a wide range of current frequency conditions. The purpose of this study was to perform measurements on the skin of the lower leg to evaluate the frequency response of the equivalent circuit model from 5 kHz to 1 MHz. Figure 2B Display the equivalent circuit model.

[0147] The same 28 long-term hemodialysis patients as in Example 1 were studied before treatment (see Table 2). Still use BIS device Xitron 4200 (Xitron Technologies, San Diego, CA) to carry out calf bioimpedance detection, the placement of electrodes is as described in the above embodiment 1 (see Image 6 ).

[0148] Calf resistance and reactance were measured with a BIS device at a logarithmically distributed frequency between 5 kHz and 1 MHz. Fat mass mass, muscle ma...

Embodiment 3

[0161] Single low frequency bioimpedance measurement

[0162] Figure 13 is a plot based on the data of Examples 1 and 2 showing a lack of correlation between muscle mass measured at 5 kHz and electrical resistance measured by MRI. This data supports the conclusion that, at low frequencies, the measured bioimpedance data do not correspond to the muscle content of a segment, but rather as image 3 As shown by the circuit model of , at these frequencies, it is the fat and extracellular fluid composition in the segments that play a major role in the measurements obtained with the bioimpedance method.

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Abstract

Methods and apparatus for providing bioimpedance analysis are provided. In certain aspects, an equivalent circuit frequency response model is provided, resulting in improved correlation with MRI data. The frequency response model takes into account body composition, including fat composition of body segments. Data obtained by Bioimpedance Spectroscopy (BIS) and MRI analysis on the subject's calf demonstrate improved correlation compared to single frequency analysis at 50 kHz and analysis with the conventional Cole-Cole model .

Description

[0001] Cross-References to Related Provisional Applications [0002] This application claims U.S. Provisional Application No. 60 / 502,483, filed September 12, 2003, U.S. Provisional Application No. 60 / 580,166, filed June 16, 2004, and U.S. Provisional Application No. .60 / 587,652 Interests under 35 USC § 119(e). The contents of all of these provisional applications are incorporated herein in their entirety. technical field [0003] The present invention relates to bioimpedance methods and apparatus, and more particularly to the use of these methods and apparatus to determine the muscle content, fat content, and / or extracellular fluid content of a subject's body segment, wherein the segment may consist essentially of The object's entire body. Background technique [0004] The electrical properties of biological tissues have been of scientific interest for a long time. During the last century, many advances and new devices based on bioelectrical knowledge have been applied in...

Claims

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Application Information

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IPC IPC(8): A61B5/05
Inventor N·W·莱文朱帆三
Owner 肾脏研究所有限公司
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