Compound injection with probenecid, potassium and beta-lactam antibiotic and its use

A technology of lactams and probenecid sodium, which is applied in the field of powder injections and freeze-dried powder injections, and can solve problems such as probenecid sodium that have not yet been seen
CN1853724AInactive Publication Date: 2006-11-01吴晓辉
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
吴晓辉
Publication Date
2006-11-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

A compound powder injection or freeze-dried powder injection is prepared from the sodium (or potassium) salt of probenecid and the beta-lactam kind of antibiotics including penicillin G, ampicillin, ancef, cefuroxime, cefotaxime and cefoxitin. It can elongate the half life of antibiotic, increase the AUC and plasma level and prevent the generation of drug-resistant bacteria.
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Description

Technical field:

[0001] The invention relates to a compound preparation composed of probenecid sodium, potassium and β-lactam antibiotics and its application, including powder injection and freeze-dried powder injection, belonging to the field of chemical pharmacy. Background technique:

[0002] Probenecid can competitively inhibit the secretion of many β-lactam antibiotics in the renal tubules and prolong their blood elimination half-life (t 1 / 2β ), increase the area under the curve (AUC), increase the blood drug concentration level, make their blood drug concentration exceed the minimum inhibitory concentration (MIC) of the corresponding bacteria, and significantly prolong the time, thereby increasing their curative effect. At present, there is no compound prescription made of probenecid and β-lactam antibiotics, but only one oral compound preparation composed of probenecid and ampicillin, that is, ampicillin probenecid capsules. In addition, since probenecid itself is no...

Claims

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