Unlock instant, AI-driven research and patent intelligence for your innovation.

Pharmaceutical preparation containing urate oxidase

A uric acid oxidase and preparation technology, which is applied in the field of pharmaceutical preparations, can solve problems such as high prices, and achieve the effect of reducing expenses and product costs

Active Publication Date: 2010-09-29
CHANGCHUN SHENGJINNUO BIOLOGICAL PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the defect that the existing pharmaceutical preparations containing urate oxidase are expensive, the present invention proposes a method that can reduce product cost and is different from the prior art, and develops a pharmaceutical preparation containing urate oxidase

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical preparation containing urate oxidase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The solution containing uric acid oxidase is obtained by dissolving the following components in water for injection according to the following parts by weight. The pH value is 8.

[0026] Uric acid oxidase 1.5

[0027] Sucrose 5

[0028] Glycine 25

[0029] Tween-80 1.0

[0030] Disodium hydrogen phosphate dodecahydrate 13.6

[0031] Sodium dihydrogen phosphate dihydrate 0.33

[0032] Water for injection 1000

Embodiment 2

[0034] The lyophilized formulation containing urate oxidase is dissolved in water for injection by dissolving the following components in the following parts by weight and then used.

[0035] Uric acid oxidase 1.5

[0036] Sucrose 5

[0037] Glycine 25

[0038] Tween-80 1

[0039] Disodium hydrogen phosphate dodecahydrate 13.6

[0040] Sodium dihydrogen phosphate dihydrate 0.33

Embodiment 3

[0042] The solution containing uric acid oxidase is obtained by dissolving the following components in water for injection according to the following parts by weight. The pH value is 6.

[0043] Uric acid oxidase 0.2

[0044] Sucrose 10

[0045] Glycine 15

[0046] Tween-80 1

[0047] Disodium hydrogen phosphate dodecahydrate 13.6

[0048] Sodium dihydrogen phosphate dihydrate 0.33

[0049] Water for injection 1000

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicinal preparation containing uricoxidase, especially medicinal preparation containing the liquid or freeze-dried composition of uricoxidase, wherein the composition comprises active compositions of uricoxidase, cane sugar, glycine, surface active agent and buffering agent. The composition can be inputted into human body through hypodermal, intra-vascular or intramuscular injection channels.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing urate oxidase, in particular to a liquid or freeze-dried composition pharmaceutical preparation containing urate oxidase. Background technique [0002] Uric acid oxidase (uric acid oxidoreductase, EC1.7.3.3, Urate Oxidase, Uricase) is an enzyme that oxidizes uric acid to allantoin. It is ubiquitous in nature and is the oldest enzyme. In most mammals, this enzyme is involved in purine metabolism and oxidizes uric acid. Uric acid oxidase consists of four identical subunits with a molecular weight of 34,500 Da, is mainly located in the liver, and is related to the function of peroxisomes. Humans and some primates lack active urate oxidase, so uric acid is the end product of purine metabolism in humans and these animals. Urate oxidase oxidizes uric acid to the more soluble allantoin and acts rapidly. In 1943, Oppenheimer first discovered through experiments that injection of urate oxidase ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K9/08A61P7/00A61K38/44
Inventor 刘国安刘沐荣康经武
Owner CHANGCHUN SHENGJINNUO BIOLOGICAL PHARMA
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com