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Medication of possessing function of anti inflammation, for improving rheological property of blood, and restraining thrombosis

A blood rheology and anti-inflammatory technology, applied in the development and research field of compound chemicals, can solve the problems of increasing the risk of cardiovascular disease and the risk of cardiovascular and cerebrovascular thrombosis.

Inactive Publication Date: 2006-12-06
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In 2004, a senior review concluded from clinical research and pharmacological evidence that the use of Cox-2 inhibitors may increase the risk of cardiovascular disease [1]
Therefore, most scholars believe that elevated blood viscosity is also one of the main risk factors for ischemic cardiovascular and cerebrovascular diseases, thereby increasing the risk of cardiovascular and cerebrovascular thrombosis

Method used

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  • Medication of possessing function of anti inflammation, for improving rheological property of blood, and restraining thrombosis
  • Medication of possessing function of anti inflammation, for improving rheological property of blood, and restraining thrombosis
  • Medication of possessing function of anti inflammation, for improving rheological property of blood, and restraining thrombosis

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Embodiment Construction

[0028] 1. Study on the prescription of compound celecoxib

[0029] 1. Research purpose

[0030] The most important adverse reactions of celecoxib are: promoting thrombosis and causing cardiovascular and cerebrovascular infarction. In this study, aiming at alleviating the adverse reaction of celecoxib in promoting thrombosis, taking the formation of thrombus in healthy rats as the observation index, the interaction between celecoxib, sodium selenite and dipyridamole was studied, in order to find the antithrombotic effect of celecoxib. A compound prescription of celecoxib, sodium selenite, and dipyramole and its prescription ratio with good inhibitory effects were formed.

[0031] 2. Experimental materials

[0032] 2.1 Drugs and reagents

[0033] Celecoxib was produced by Pfizer Pharmaceutical Co., Ltd. (batch number: BK050609), sodium selenite was purchased from Zhengzhou Furunde Industry and Trade Co., Ltd. (batch number: 041121), and Dimectamole was produced by Shanxi Linf...

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Abstract

A kind of 4 anti-inflammatory medicines for improving the rheological property of blood, suppressing thrombosis and treating inflammatory arthritis is prepared proportionally from Sailaixibu, sodium selenite and dipyridamole.

Description

technical field [0001] The invention relates to the development and research of a class of compound chemical medicines (new drug class I (5)), in particular to a compound medicine having anti-inflammatory effects, improving blood rheology and inhibiting thrombus formation. Background technique [0002] 1. Coxib (--coxib) drugs are selective non-steroidal anti-inflammatory drugs (NSAIDs), that is, highly selective cyclooxygenase-2 (Cox-2) inhibitors. (Cox-1) inhibitory effect is weak, therefore, coxibs reduce the incidence of common gastrointestinal adverse reactions of NSAIDs, have obvious anti-inflammatory effects, and have the advantages of slight stimulation to the gastrointestinal tract, and are sold very well in the world. big. In 2004, a senior review concluded from clinical research and pharmacological evidence that the use of Cox-2 inhibitors may increase the risk of cardiovascular disease [1] . Because rofecoxib (rofecoxib) causes the ...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K31/415A61K31/52A61P29/00A61P7/02
Inventor 袁秉祥唐俊杰
Owner XI AN JIAOTONG UNIV