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Distillage of Ardisia chinensis Benth of possessing function of antivirus, distilling method and application

A kind of antiviral effect, the technology of small purple golden cattle, applied in antiviral agents, pharmaceutical formulas, plant raw materials, etc., can solve the problems of lagging development and utilization of herbal medicines, no research on the chemical components of small purple golden cattle and their biological activity systems, etc.

Inactive Publication Date: 2006-12-06
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after searching, there is no systematic research on the chemical constituents and biological activities of Zijinniu, which leads to a lag in the development and utilization of this herbal medicine.

Method used

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  • Distillage of Ardisia chinensis Benth of possessing function of antivirus, distilling method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Preparation of the water extract of Zijin Niu

[0059] Take the whole plant of Xiaozijinniu after drying in the shade and chopping, use 10 times the amount of water, and extract twice at 100°C under reflux, each time for 1 to 2 hours, filter the extract, and concentrate the filtrate into an extract with a rotary evaporator. Dried in a vacuum oven or spray-dried to a brown powder, which is the water extract of Zijinniu. Calculated by the weight of the dry extract, it contains 30-20% polysaccharides and 20-30% total polyphenols.

Embodiment 2

[0060] Example 2: Preparation of the crude polysaccharide of Zijinniu

[0061] Take the whole plant of Xiaozijinniu that has been dried in the shade and chopped, use 10 times the amount of water, and extract twice at 100°C under reflux, each time for 1 to 2 hours, filter the extract, and concentrate the filtrate with a rotary evaporator to a relative density of 1.05 -1.15 (60°C), centrifuge to obtain the supernatant, add 95% ethanol solution until the ethanol concentration in the system is 60-80%, stir overnight to completely precipitate the precipitate, centrifuge the precipitate, dry to obtain a dry product, which is Xiaozijin Bovine crude polysaccharide. Calculated by the weight of the dry extract, the polysaccharide content of Xiaozijinniu is 60-80%, and the total polyphenol content is 5-10%.

Embodiment 3

[0062] Example 3: Preparation method 1 of Xiaozijinniu polysaccharide

[0063] Weigh 100g of DEAE Cellulose-52 ion exchange resin, add 500mL of distilled water, stir evenly, remove a small amount of cellulose monomer or fragments by water flotation, and then place it at room temperature for 24 hours. After the resin is fully swollen, drain the resin. Activate the resin according to the instructions. Add 300mL of distilled water to the activated resin, degas it with ultrasonic waves, stir it evenly, pour it carefully and slowly into the column along the glass rod, and tap the column wall lightly at the same time to make the resin settle evenly and tightly, then fully pour it with distilled water Wash for 48 hours and place overnight to equilibrate the column.

[0064] Weigh 200mg dry product of Xiaozijinniu crude polysaccharide, heat and dissolve in 1mL distilled water, after ultrasonic degassing, put the sample into the above-mentioned activated and balanced ion exchange colu...

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Abstract

An antiviral extract of Ardisia chinensis Benth is prepared from the dried plant of Ardisia chinensis Benth through extracting in water and purifying. It can be used to prepare the medicine, health-care product, or food for preventing and treating the diseases caused by HBV and CoxB3 virus.

Description

technical field [0001] The present invention relates to medicinal extracts derived from plant materials and their extraction methods and applications, in particular to the extracts of the plant Auranthus chinensis and their extraction methods and applications. Background technique [0002] There are many diseases caused by virus infection in the human body, and they are also very harmful. For example, chronic hepatitis caused by hepatitis B virus (HBV) can lead to chronic viral infection, lymphoma disease and chronic kidney disorder. At present, there are about 200 million people in the world who are carriers of HBV virus, 80% of which are concentrated in the Asia-Pacific region, and most of them are positive for hepatitis B virus surface antigen (HBsAg) in their blood. Although some drugs for the treatment of hepatitis B virus have been developed, there are no satisfactory drugs. Synthetic drugs such as phosphine formate, suramin, 2-deoxyguanosine, etc. have large side effe...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/715A61P31/12A61P31/20
Inventor 李药兰岑颖洲许少玉伍秋明苏妙贤
Owner JINAN UNIVERSITY
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