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Use of nocardia rubra cell wall skeleton in preparation of medicine for resisting mycotic infection

A technology of Nocardia rubrum and cell wall, which is applied in the field of Nocardia rubrum cell wall skeleton in the preparation of antifungal infection drugs, which can solve the problems of burning skin, easy recurrence of disease, slow effect and other problems

Active Publication Date: 2012-06-20
LIAONING GREATEST BIO-PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But topical use can cause rashes, redness, blisters, burning, and other skin irritations
Moreover, it consumes a lot of medicine, takes effect slowly, and the condition is easy to relapse.

Method used

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  • Use of nocardia rubra cell wall skeleton in preparation of medicine for resisting mycotic infection
  • Use of nocardia rubra cell wall skeleton in preparation of medicine for resisting mycotic infection
  • Use of nocardia rubra cell wall skeleton in preparation of medicine for resisting mycotic infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Immunity test of Nocardia rubrum cell wall skeleton preparation (Nr-CWS) on mice

[0020] 1. Purpose of the test

[0021] In this experiment, the phagocytosis of Candida albicans by peritoneal macrophages of mice immunized with Nocardia red cell wall skeleton preparation (Nr-CWS) proved that Nocardia red cell wall skeleton preparation (Nr-CWS) can activate the body macrophages, and can enhance the body's immunity.

[0022] 2. Test materials

[0023] 1. Experimental drug Nocardia rubrum cell wall skeleton freeze-dried powder (Nr-CWS), 60 μg / 2 ml, batch number: 20040701, Shenyang Shengbaokang Biopharmaceutical Co., Ltd.

[0024] 2. Test strain Candida albicans Y01.109-001, Institute of Dermatology, Chinese Academy of Sciences.

[0025] 3. Experimental animals BALB / C mice, SPF grade, 18-20g, China Institute for the Control of Pharmaceutical and Biological Products, production license: SCXK (Beijing) 2000-0010.

[0026] 3. Test method

[0027] 1. The source of the test...

Embodiment 2

[0047] The therapeutic effect of Nocardia rubrum cell wall skeleton preparation (Nr-CWS) on animal models of fungal vaginitis

[0048] 1. Purpose of the test

[0049] The animal model of mycotic vaginitis was established to verify the curative effect of Nocardia rubrum cell wall skeleton preparation (Nr-CWS) on mycotic vaginitis animals.

[0050] 2. Test materials

[0051] 1. Test drug Nocardia rubrum cell wall skeleton preparation, 60 μg / bottle, batch number: 20040701, Shenyang Shengbaokang Biopharmaceutical Co., Ltd.

[0052] 2. Positive control drug Daktarin suppository, 200mg / tablet, batch number: 041024753, Xi'an Janssen Pharmaceutical Co., Ltd.

[0053] 3. Experimental animal Japanese big-eared rabbit, common grade, female, 2-2.5kg.

[0054] 4. Test strain Candida albicans Y01: 109-005 Institute of Dermatology, Chinese Academy of Sciences.

[0055] 3. Method

[0056] 1. The source of the test method refers to "Therapeutic Effects of Fluconazole Gel on Animal Models ...

Embodiment 3

[0075] Example 3 Nocardia rubrum cell wall skeleton preparation for the treatment of oral mucosal candidiasis infection

[0076] Case 1: 38 years old, female, there were scattered small white ulcers under the tongue, and there was a burning sensation.

[0077] After clinical diagnosis, it was confirmed as Candida infection of oral mucosa. Dilute the cell wall skeleton preparation of Nocardia rubrum with physiological saline, soak the cotton ball, and attach it to the affected part of the oral cavity.

[0078] Attach for 40-60 minutes each time, apply medicine once in the morning and evening, one liniment (10 μg / 2 ml) each time.

[0079] Pain relief after 2 times of medication; recovery from illness after 4 times of medication.

[0080] Case 2: A 69-year-old male, a patient undergoing radiotherapy and chemotherapy, had two scattered white ulcers on the left cheek of the mouth, a burning sensation, and dry mouth.

[0081] After clinical diagnosis, it was confirmed as Candida ...

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Abstract

The invention provides the use of nocadia rubra cell wall skeleton (Nr-CWs) in preparing medicament for resisting diseases caused by fungus infection, especially diseases caused by candida albicans infection. The obtained medicament can be applied locally, preferably used as liniment.

Description

technical field [0001] The present invention relates to the use of Nocardia rubra cell wall skeleton (Nr-CWS) in the preparation of medicines against fungal infections, in particular to the use of Nocardia rubrum cell wall skeletons (Nr-CWS) in the preparation of medicines against Candida albicans infection use in . Background technique [0002] Candida albicans (also known as Candida) is a saprophytic bacterium that widely exists in nature and belongs to the normal parasitic flora of the human body. Under the influence, parasitic Candida albicans can produce pathogenicity and cause disease. Candida is a bidirectional fungus, which has a yeast phase and a hyphae phase. It is a yeast phase when it is parasitic. It is generally non-pathogenic, but it can transform into a pathogenic mycelium phase under certain conditions. Candida albicans can infect almost any tissue and organ in the body, and can cause a variety of diseases: diseases caused by infection of the oral cavity s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K35/74A61P31/10
Inventor 张策张轶洪晓明张国英
Owner LIAONING GREATEST BIO-PHARM CO LTD