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Anti-inflammatory analgesic for external use

一种消炎镇痛、外用药的技术，应用在外用药领域，能够解决NSAID渗透扩散性降低、没有考虑肌肉或关节组织渗透性或扩散性等问题

Inactive Publication Date: 2007-02-07
MEDRX CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, the permeability or diffusibility of the muscle or joint tissue in the lower part of the skin was not considered
However, according to the research of the present inventors, it is found that the dynamics of the preparations containing NSAID and local anesthetics in muscle tissue are not the same. Due to the co-existence of local anesthetics, sometimes the penetration and diffusion of NSAIDs will be reduced.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0041] According to the mixing ratio in Table 1, etodolac and the like were dissolved in polyethylene glycol 400 to prepare test solution 1 containing etodolac and lidocaine and test solution 2 containing only etodolac. In addition, the numerical value in Table 1 is a mass part.

[0042] Test solution 1

preparation example 2

[0047] Preparation Example 2 Preparation of patch of the present invention

[0048] According to the mixing ratio (parts by mass) in Table 3, a patch equipped with etodolac-lidocaine was prepared by using the toluene solvent method. That is, firstly etodolac, lidocaine and polyethylene glycol are heated and mixed at 40° C. until clear. In addition, dissolve styrene-isoprene-styrene block copolymer, liquid paraffin, alicyclic saturated hydrocarbon resin and dibutylhydroxytoluene in toluene, and then add the mixture of etodolac and lidocaine , and further mixed to obtain a homogeneous melt. Apply the molten material on the protective film (polyester) with a coating machine, and make the paste weight after drying 100g / m 2 , and then heated and dried to evaporate toluene. The obtained coated surface is bonded to a support (non-woven fabric), and cut according to the required size to obtain a patch.

[0049] mix ratio

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PUM

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Abstract

An objective of the present invention is to provide an anti-inflammatory analgesic for external use comprising etodolac as NSAID. The anti-inflammatory analgesic for external use is excellent not only in skin permeability but also in penetratability and diffusivity into tissues present in portions deeper than the skin, can act directly on the muscles or joint tissues with inflammation or pain, and is a little irritant to the skin. The anti-inflammatory analgesic for external use of the present invention is characterized by comprising etodolac and a local anesthetic.

Description

technical field [0001] The invention relates to an external medicine with anti-inflammatory and analgesic effects. Background technique [0002] As we all know, conventional anti-inflammatory analgesic drugs are non-steroidal anti-inflammatory analgesic drugs (Non-Steroidal Anti-Inflammatory Drugs, hereinafter referred to as "NSAID"). NSAIDs have the effect of inhibiting the synthesis of prostaglandins by blocking the cyclooxygenase (hereinafter referred to as "COX") that catalyzes the initial reaction in the arachidonic acid cascade reaction of the metabolic pathway that enhances pain. Prostaglandins and Inflammation or pain related. [0003] However, prostaglandins have various effects other than so-called inflammatory and pain effects, and if the production of prostaglandins is excessively suppressed by using NSAIDs, serious side effects will occur. For example, when the function of COX is inhibited, the activity of lipoxygenase is increased instead, leukotrienes increa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/08A61K9/06A61K9/12A61K9/70A61K31/407A61K47/18A61P29/00
CPCA61K9/0014A61K9/7053A61K9/7076A61K31/407A61P29/00A61K31/167
Inventor 滨本英利石桥贤树松村周永子山崎启子
Owner MEDRX CO LTD
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