Penciclovir emulsifiable paste and its preparation

A technology of penciclovir and cream, which is applied in the field of anti-herpes virus drugs, can solve the problems of inconvenient use and high treatment cost, and achieve the effect of easy washing, low drug cost and easy acceptance

Inactive Publication Date: 2007-02-28
湖北科益药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment methods are mainly: oral antiviral drugs such as acyclovir, valaciclovir, etc.; or intravenous antiviral drugs such as acyclovir, ganciclovir, interferon, two globulins, etc.; The method not only has high treatment cost and is inconvenient to use, but also uses systemic administration, which inevitably brings certain side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Penciclovir 10g

[0012] Tween-80 50g

[0013] Span-60 20g

[0014] Cetyl Alcohol 60g

[0015] White Vaseline 120g

[0016] Glyceryl monostearate 10g

[0017] Liquid paraffin 80g

[0018] Propylene glycol 100g

[0019] Chlorobutanol 5g

[0020] Distilled water up to 1000g

[0021] Heat and melt Span 60, cetyl alcohol, white petrolatum, glyceryl monostearate and liquid paraffin to form an oil phase, and keep warm to (75-85°C). In addition, heat propylene glycol and distilled water to 75-85°C, then add Tween-80 and chlorobutanol to dissolve into water phase. Add the main drug penciclovir into the water phase, stir evenly, then pour the water phase into the oil phase, stir while adding, stop heating after 15-20 minutes, and continue stirring to room temperature. Filling, packaging, and ready to serve.

Embodiment 2

[0023] Penciclovir 10g

[0024] Sodium Lauryl Sulfate 10

[0025] Cetyl Alcohol 60g

[0026] White Vaseline 120g

[0027] Glyceryl monostearate 10g

[0028] Liquid paraffin 80g

[0029] Propylene glycol 100g

[0030] Methylparaben 2g

[0031] Propylparaben 0.2g

[0032] Distilled water up to 1000g

[0033] Take cetyl alcohol, white vaseline, glyceryl monostearate, propylparaben and liquid paraffin and heat and melt to form an oil phase, and keep warm to (75-85°C). In addition, heat propylene glycol and distilled water to 75-85°C, then add sodium lauryl sulfate and methylparaben to dissolve into the water phase. Add the main drug penciclovir into the water phase, stir to dissolve it completely, then pour the water phase into the oil phase, stir while adding, stop heating after 15-20 minutes, and continue stirring to room temperature. Filling, packaging, and ready to serve.

Embodiment 3

[0035] Penciclovir 10g

[0036] Stearic acid 120

[0037] Triethanolamine 10

[0038] Cetyl Alcohol 60g

[0039] White Vaseline 120g

[0040] Glyceryl monostearate 10g

[0041] Liquid paraffin 80g

[0042] Propylene glycol 100g

[0043] Benzyl alcohol 10g

[0044] Distilled water up to 1000g

[0045] Take stearic acid, cetyl alcohol, white petrolatum, glyceryl monostearate, liquid paraffin, and benzyl alcohol and heat and melt to form an oil phase, and keep warm to (75-85°C). In addition, heat propylene glycol and distilled water to 75-85°C, then add triethanolamine to dissolve into water phase. Add the main ingredient penciclovir into the water phase, stir to dissolve it completely, then mix the water phase with the oil phase, stir, stop heating after 15-20 minutes, and continue stirring to room temperature. Filling, packaging, and ready to serve.

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PUM

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Abstract

The invention relates to a Penciclovir dispersible paste which comprises Penciclovir 0.5-2.0 wt%, emulsifying agent 1.0-10.0 wt%, methyl glycol 5.0-20.0 wt%, antiseptic agent 0.01-0.5 wt%, glyceryl monostearate 1.0-5.0 wt%, hexadecyl alcohol 5.0-15.0 wt%, dahurian angelica root pieces 5.0-15.0 wt%, liquid paraffin 5.0-15.0 wt%, and balancing water. The invention also discloses the process for preparing the dispersible paste.

Description

technical field [0001] The invention belongs to an anti-herpes virus medicine, in particular to a penciclovir cream preparation and a preparation method. Background technique [0002] Herpes virus infection is a common and frequently-occurring disease, and the recurrence rate of cold sores is high. According to reports, more than 40 million people in the United States suffer from herpes labialis each year, and most patients suffer from 1-3 episodes per year. Penciclovir is a broad-spectrum nucleoside antiviral drug, which is clinically used to treat viral skin diseases caused by herpes viruses, such as herpes simplex on the lips and face, chickenpox, and herpes zoster. The current treatment methods are mainly: oral antiviral drugs such as acyclovir, valaciclovir, etc.; or intravenous antiviral drugs such as acyclovir, ganciclovir, interferon, two globulins, etc.; The method not only has high treatment cost and is inconvenient to use, but also uses systemic administration, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/522A61P31/12
Inventor 刘红李开兰李亚军熊增慧余修祥郑学文
Owner 湖北科益药业股份有限公司
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