Drop pills for treating coronary heart disease, angina pectoris and preparation method thereof

A technology for angina pectoris and coronary heart disease, applied in the field of traditional Chinese medicine preparations, can solve the problems of less toxic and side effects of western medicine, toxic and side effects, and difficulty in curing the root cause, and achieve the effects of small dosage, controllable quality and advanced dosage form.

Inactive Publication Date: 2007-04-25
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs for the treatment of coronary heart disease and angina pectoris mainly include nitrate lipid compounds, β receptor blockers and Ca 2+ Antagonists, etc. For severe and emergency patients, these compounds can relieve symptoms, but it is difficult to cure the root cause, and has certain toxic and side effects, especially for some angina pectoris related to abnormal platelet function, the adverse effects of using antiplatelet drugs effect, also caused widespread concern, due to the side effects and adverse reactions of the above-mentioned drugs, its application is subject to certain restrictions
[0003] Traditional Chinese medicine has a long history in the treatment of cardiovascular diseases. Although the single-target effect of traditional Chinese medicine is lower than that of Western medicine, its multi-channel, multi-target, and less toxic and side effects are far beyond the reach of Western medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0039] prescription:

[0040]Chuanxiong Extract 78g

[0041] Styrax 25g

[0042] ice flakes 45g

[0043] Macrogol 4000 222g

[0044] -------------------------------------------------- ----------------------

[0045] Make 10000 capsules

[0046] Preparation:

[0047] Ligusticum chuanxiong is crushed into the coarsest powder. Add 2 times the amount of 50% ethanol to immerse at room temperature for 24 hours, and release the immersion solution. Add 2 times the amount of 50% ethanol to the dregs and soak at room temperature for 24 hours to release the soaking liquid. Add 2 times the amount of 50% ethanol to the dregs and soak at room temperature for 24 hours to release the soaking liquid. Combine the 3 dips. Recover ethanol under reduced pressure, concentrate to a thick paste (relative density about 1.35, 60°C) after recovering all ethanol, and obtain Chuanxiong extract for storage in a separate container. Add Chuanxiong extract, storax, and borneol into molten polyethyl...

example 2

[0049] prescription:

[0050] Chuanxiong Extract 111g

[0051] Styrax 19.5g

[0052] ice flakes 39g

[0053] Macrogol 6000 339g

[0054] -------------------------------------------------- ----------------------

[0055] Make 10000 capsules

[0056] Ligusticum chuanxiong is crushed into the coarsest powder. Add 3 times the amount of 75% ethanol to immerse at room temperature for 24 hours, and release the immersion solution. Add 2 times the amount of 60% ethanol to the dregs and soak at room temperature for 24 hours to release the soaking liquid. Add 2 times the amount of 60% ethanol to the dregs and soak at room temperature for 24 hours to release the soaking liquid. Combine the 3 dips. Recover ethanol under reduced pressure. After all ethanol is recovered, it is concentrated into a thick paste with a relative density of about 1.35 (70°C). Chuanxiong extract, styrax, and borneol are added to molten polyethylene glycol, stirred to dissolve and mixed evenly, and kept at...

example 3

[0058] prescription:

[0059] Chuanxiong Extract 156g

[0060] Styrax 30g

[0061] ice flakes 30g

[0062] Macrogol 6000 650g

[0063] -------------------------------------------------- ----------------------

[0064] Make 10000 capsules

[0065] Ligusticum chuanxiong is crushed into the coarsest powder. Add 5 times the amount of 75% ethanol to immerse at room temperature for 24 hours, and release the immersion solution. Add 2 times the amount of 75% ethanol to the dregs and soak at room temperature for 24 hours to release the soaking liquid. Add 2 times the amount of 75% ethanol to the dregs and soak at room temperature for 24 hours to release the soaking liquid. Combine the 3 dips. Ethanol was recovered under reduced pressure. After recovering all the ethanol, it was concentrated into a thick paste (relative density was about 1.35, 70°C), and the Chuanxiong extract was stored in a separate container. Chuanxiong extract, styrax, and borneol are added to molten polye...

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PUM

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Abstract

The invention relates to a drop for treating coronary disease and stenocardia, and relative production. Wherein, it is formed by 200-500g chuanxiong rhizome extractive, 10-30g storax, 15-50g borneol, carbowax 4000 or carbowax 6000 or their mixture while the total weight of mixture is 1:0.5-10. And the preparation comprises that adding chuanxiong rhizome extractive, storax, borneol into fused carbowax, mixing uniformly; at 60-70Deg.C, adding it into liquid wax or dimethicone (at 5-10Deg. C), condensing into drop, removing the liquid wax or dimethicone, and packing. The invention has controllable quality.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a Chuansu Jiuxin dripping pill for treating coronary heart disease and angina pectoris and a preparation method thereof. Background technique [0002] Coronary heart disease and angina pectoris are common emergencies in the Department of Cardiology. They belong to the category of chest pain and heart pain in the traditional Chinese medicine. The main clinical manifestations are chest tightness and precordial compression pain. They are caused by insufficient coronary blood supply. A series of clinical symptoms caused by hypoxia. The onset is fast and the harm is great. In severe cases, symptoms such as myocardial infarction and arrhythmia may appear. If treated in time, the progression of the disease can be avoided and the occurrence of myocardial infarction can be prevented. At present, the drugs for the treatment of coronary heart disease and angina pectoris mainly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61K36/185A61K31/045A61K9/20A61P9/10
Inventor 吕沅珊郑雅楠任涛华伟义
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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