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Orally administered pharmaceutical composition

An oral preparation and adhesive layer technology, applied in the field of oral preparations, can solve the problems of blocking tracheoesophageal tumors and reducing medication compliance

Inactive Publication Date: 2007-05-02
LINTEC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the case of oral preparations, medication compliance may decrease due to various reasons such as discomfort caused by the bitter or astringent taste of the drug, gas or vomiting caused by taking the drug, and drug rejection.
[0003] For example, when the oral preparation is a solid preparation (such as tablet, capsule preparation, etc.) in the usual dosage form, it is difficult to swallow directly, so it is necessary to take a large amount of water at the same time, and the medication compliance sometimes decreases
Especially for the elderly and young children, sometimes it is impossible to swallow solid dosage forms, and there is often a decrease in medication compliance
In addition, when using solid preparations, there is also the risk of blockage of the trachea due to misuse and the risk of adhesion to the esophagus to form esophageal tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach

[0030] Fig. 1(a) is a plan view showing the first embodiment of the oral preparation of the present invention, and Fig. 1(b) is a sectional view showing the same embodiment (X-X sectional view in Fig. 1(a)).

[0031] As shown in FIG. 1 , the oral preparation 1a according to the first embodiment has water-swellable gel-forming layers 12 and 12' provided on the outermost layer of the oral preparation 1a, laminated on the water-swellable gel-forming layer 12 and The drug-containing layer 11 between 12', the peripheral part of the water-swellable gel-forming layer 12 and the peripheral part of the water-swellable gel-forming layer 12' are directly bonded together, so that the drug-containing layer 11 is enclosed in the oral preparation 1a. internal.

[0032] The oral preparation 1a is preferably a film-form preparation (tablet-form preparation). When the oral preparation 1a is a film-like preparation, since the moisture content in the preparation can be suppressed lower, the drug...

no. 2 approach

[0074] Fig. 2(a) is a plan view showing a second embodiment of the oral preparation of the present invention, and Fig. 2(b) is a sectional view showing the same embodiment (X-X sectional view in Fig. 2(a)).

[0075] As shown in FIG. 2, the oral preparation 1b according to the second embodiment has water-swellable gel-forming layers 12 and 12' provided on the outermost layer of the oral preparation 1b, and is laminated under the water-swellable gel-forming layer 12. The adhesive layer 13, the adhesive layer 13' laminated on the water-swellable gel-forming layer 12', the water-swellable gel-forming layer 12 and the adhesive layer laminated via the adhesive layers 13 and 13' The drug-containing layer 11 between 12', the peripheral part of the water-swellable gel-forming layer 12 and the peripheral part of the water-swellable gel-forming layer 12' are bonded by the adhesive layer 13 and 13', so that the drug The containing layer 11 is enclosed in the oral preparation 1 . In addit...

Embodiment

[0097] Hereinafter, the present invention will be described in more detail with reference to production examples and test examples.

[0098] (1) Preparation of water-swellable gel-forming layer-forming liquid (coating liquid A)

[0099] A coating liquid A for forming a water-swellable gel-forming layer having the following composition was prepared. That is, 140 g of purified water was taken, 1 g of potassium aluminum sulfate (calimiyouban) was added thereto, and stirred for about 10 minutes to completely dissolve it. Then, 6 g of polyacrylic acid (Carbopol 974P (BF Gutdrich)) was slowly added with stirring, and stirred for about 1 hour to completely dissolve it. Then, 17 g of polyvinyl alcohol (Go-Seno-lu EG-05T (Nippon Synthetic Chemical)) was slowly added with stirring, and stirred for about 1 hour while heating to 70° C. to completely dissolve it.

[0100] In addition, polyacrylic acid is cross-linked by aluminum ions generated by the ionization of aluminum potassium sulf...

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Abstract

It is an object of the present invention to provide an orally administered pharmaceutical composition capable of completely masking the flavor, odor and the like of a drug contained in a drug-containing layer, and to achieve this object, the outer edge of a first water-swellable gel-forming layer 12a and the outer edge of a second water-swellable gel-forming layer 12' are bonded together so as to enclose a drug-containing layer 11 inside an orally administered pharmaceutical composition 1a in the orally administered pharmaceutical composition 1a comprising the first water-swellable gel-forming layer 12a and the second water-swellable gel-forming layer 12' in the outermost layer.

Description

technical field [0001] The present invention relates to oral formulations. Background technique [0002] In the case of oral preparations, medication compliance may be reduced due to various reasons such as discomfort caused by the bitter taste or astringent taste of the drug, gas or vomiting caused by taking the drug, and drug rejection. [0003] For example, when the oral preparation is a solid preparation (for example, tablet, capsule preparation, etc.) in the usual dosage form, it is difficult to swallow directly, so a large amount of water must be taken at the same time, and the medication compliance sometimes decreases. Especially for the elderly and young children, solid preparations cannot be swallowed sometimes, and the compliance of taking medicine often decreases. In addition, when the solid preparation is used, there is also the risk of clogging the trachea due to misuse and the risk of adhering to the esophagus to form an esophageal tumor. [0004] Therefore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K9/50
CPCA61K9/284A61K9/2846A61K9/2886A61K9/2893A61K31/426A61K9/28
Inventor 野上英志
Owner LINTEC CORP