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Method for reducing residual alcohols in crystalline valacyclovir hydrochloride

A technology of valacyclovir hydrochloride and valacyclovir, which is applied in the field of a method of propanol, and can solve problems such as unsatisfactory effects and toxicity

Inactive Publication Date: 2007-06-06
TEVA PHARMA IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solvent can be toxic and can have undesirable effects in patients receiving valacyclovir hydrochloride

Method used

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  • Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
  • Method for reducing residual alcohols in crystalline valacyclovir hydrochloride

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Abstract

Provided is valacyclovir hydrochloride stable against formation of N'-formylvalacyclovir upon storage at elevated humidity and pharmaceutical compositions including such valacyclovir hydrochloride.

Description

Cross-references to related applications This application is a continuation-in-part of U.S. Patent Application 10 / 688,538, filed October 16, 2003, which is required by U.S. Provisional Patent Application 60 / 419,270, filed October 16, 2002 and November 18, 2002 Priority to U.S. Provisional Application 60 / 427,320, filed on 1999, all of which are hereby incorporated by reference. Background of the invention Valacyclovir (valacyclovir) is the L-valyl ester prodrug of acyclovir. Acyclovir is an acyclic analog of natural nucleosides that has been found to have high antiviral activity. Aciclovir is widely used in the treatment and prophylaxis of viral infections in humans, especially those caused by herpes viruses. See Goodman and Gilman's, The Pharmacological Basis of Therapeutics 1193-1198 (9th ed. 1996). Acyclovir is an acyclovir analog lacking a 3'-hydroxyl group on the side chain. The chemical name of acyclovir is 6H-purin-6-one, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D473/18C07D473/00
CPCC07D473/00C07D473/18A61P31/22
Inventor B·-Z·多利茨基I·利夫什茨
Owner TEVA PHARMA IND LTD
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