Particles comprising a biopolymer which is degradable under the effect of an electromagnetic wave as emitted by a solar radiation

a biopolymer and electromagnetic wave technology, applied in the direction of biocide, drug composition, hair cosmetics, etc., can solve the problems of limited cosmetic use, increased internal osmotic pressure and gel swelling, and incompatible with the expected rapid degradation

Inactive Publication Date: 2004-06-24
BASF BEAUTY CARE SOLUTIONS FRANCE SAS
View PDF7 Cites 34 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these compounds are highly toxic and this limits their uses in cosmetics (Vyas et al., 1985, Neurotoxicology, 6, 3, 123-132; Hayashi et al., 1989, Arch. Toxicol., 63, 4, 308-313).
However, the doses of solar energy which are necessary for the degradation of the film are very significant (500,000 kJ/m.sup.2), doses which correspond to more than 15 days of exposure in full Summer (Getlichermann et al., 1994, Polym. Deg. Stab., 43, 343-352) and which are therefore incompatible with the rapid degradation expected during a daily solar exposure (as an indication, the daily solar energy received varies from 5,000 to 10,000 kJ/m.sup.2).
The ultra-violet light first of all creates an ionization reaction in the gel formed...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Particles comprising a biopolymer which is degradable under the effect of an electromagnetic wave as emitted by a solar radiation
  • Particles comprising a biopolymer which is degradable under the effect of an electromagnetic wave as emitted by a solar radiation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0064] Method of Preparation of Microcapsules Based on Marine DNA

[0065] a) A solution (1 kg) containing 4.8% (w / w) of sodium carbonate and 0.4% (w / w) of methyl paraben is prepared in pure laboratory water. Under mechanical agitation, 2% (w / w) of DNA of high molecular weight (extract of fish milt) is added. The agitation is maintained until a clear gel is obtained.

[0066] b) 9.6 ml of sebacoyl chloride are added to 320 g of caprylic / capric triglycerides oil (oily base). The whole is poured into 960 g of DNA gel under strong agitation made by an Ultra Turax.RTM. (IKA) type apparatus. A mechanical agitation is then maintained for 45 minutes.

[0067] c) The spheres are then separated from the reaction medium by centrifugation (3,800 rpm for 5 minutes).

[0068] d) Several washings with water are carried out so as to remove the excess of DNA gel which has not reacted as well as sodium sebacate.

[0069] e) The microcapsules recovered have a size of between 2 and 80 .mu.m in diameter; they are the...

example 2

[0070] Method of Preparation of Microspheres Based on Marine DNA

[0071] a) A solution (1 kg) containing 4.8% (w / w) of sodium carbonate and 0.4% (w / w) of methyl paraben is prepared in pure laboratory water. Under mechanical agitation, 2% (w / w) of DNA of high molecular weight (fish extract) is added. The agitation is maintained until a clear gel is obtained.

[0072] b) 144 g of terephthalic acid dichloride are dispersed in 3,600 g of caprylic / capric triglycerides oil.

[0073] c) In a cell, 54 g of sorbitan trioleate (Span 85, ICI) are dispersed in 2,700 g of caprylic / capric triglycerides oil.

[0074] d) 900 g of DNA gel prepared in a) are then placed in the cell under mechanical agitation. The solution prepared in b) is then added to the whole under mechanical agitation and the whole is agitated for 10 minutes by an Ultra Turax.RTM. (IKA) type agitator system. A reduced mechanical agitation is then maintained for 20 additional minutes.

[0075] e) The spheres obtained, of a size of 5 to 80 .mu....

example 3

[0078] Sensitivity to Solar Irradiation of Various Polymers

[0079] Various polymers, which are used classically in cosmetics for microencapsulation, were used for preparing the control microcapsules, according to the protocol described in Example 1. Thus, for example, microspheres were made from collagen and glycosaminoglycans according to the patent FR 2,642,329 (U.S. Pat. No. 5,395,620) (COLETICA), from plant proteins from wheat or from lupin according to the patent FR 2,766,090 (U.S. Pat. No. 5,912,016) (COLETICA), or from polysaccharides such as acacia according to the patent FR 2,688,422 (U.S. Pat. No. 5,562,924) (COLETICA).

[0080] A liposoluble colorant, having an absorption peak at 582 nm, was introduced in the oily phase.

[0081] The microspheres prepared in Example 1, as well as those prepared with the various polymers described above, are diluted to 25% (w / w) in a carbomer gel. 87.5 g of pure laboratory water containing 0.5% of sodium tricitrate are then added to 12.5 g of the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Timeaaaaaaaaaa
Forceaaaaaaaaaa
Forceaaaaaaaaaa
Login to view more

Abstract

The invention relates mainly to a particle comprising at least one biopolymer which is degradable under the effect of an electromagnetic wavelength, notably the wavelength of which is in the spectrum of the wavelengths emitted by the sun, this biopolymer comprising nucleosides. The invention also relates to compositions containing such particles with the aim of delivering an active principle. These particles can be used mainly in cosmetics, in dermatology, in pharmacy, in agri-food or en agro-industrials.

Description

[0001] The invention relates mainly to a particle comprising at least one biopolymer which is degradable under the effect of an electromagnetic wave, notably the wavelength of which is in the spectrum of the wavelengths emitted by the sun, this biopolymer comprising nucleosides.[0002] More particularly, the invention finds cosmetic, dermatological, pharmaceutical, agri-food or agro-industrial use, in releasing an active principle contained by this particle when it is subjected to an electromagnetic wave.STATE OF THE ART[0003] With the aim of better mastering the bioavailability and the release of a microencapsulated active, many studies have been made so as to develop microcapsules or microspheres which release their actives under the influence of physical factors such as pH or temperature.[0004] For pharmaceutical applications, the use of pH-dependent polymers such as Eudragit.RTM. S and L (Bayer), cellulose acetate phthalate, cellulose acetate trimellitate and hydroxypropyl methyl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/30A01N63/00A61K8/00A61K8/02A61K8/04A61K8/06A61K8/11A61K8/14A61K8/60A61K8/67A61K9/00A61K9/127A61K9/50A61K9/51A61K9/52A61K45/00A61K45/06A61P17/00A61P17/16A61Q1/00A61Q1/04A61Q1/06A61Q5/02A61Q17/04A61Q19/00A61Q19/10C08J5/00C08L101/16
CPCA61K8/11A61K8/606A61K9/0009A61K2800/412A61K2800/413A61Q1/06Y10T428/2982A61Q17/04B82Y5/00A61Q19/00A61K8/14A61K2800/81A61Q5/02A61P17/00A61P17/16A61K9/5036A61K9/51C08J5/00B82Y30/00
Inventor PERRIER, ERICBONNET, ISABELLEDE MATTEIS, CHARLOTTE
Owner BASF BEAUTY CARE SOLUTIONS FRANCE SAS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap