Compounds, compositions, and methods

a technology of compositions and compounds, applied in the field of compositions and methods, can solve the problems of limiting the usefulness of compounds, inducing cancer cell death, and inhibiting cancer cell division
US20060019988A1Inactive Publication Date: 2006-01-26CYTOKINETICS INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
CYTOKINETICS INC
Publication Date
2006-01-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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Description

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 60 / 389,265, filed Jun. 14, 2002 and of U.S. Provisional Patent Application No. 60 / 389,779, filed Jun. 18, 2002; each of which is incorporated herein by reference for all purposes.FIELD OF THE INVENTION

[0002] This invention relates to compounds which are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, for example cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. BACKGROUND OF THE INVENTION

[0003] Among the therapeutic agents used to treat cancer are the taxanes and vinca alkaloids, which act on microtubules. Microtubules are the primary structural element of the mitotic spindle. The mitotic spindle is responsible for distribution of replicate copies of the genome to each of the two daughter cells that result from cell division. It is pre...

Claims

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