Selective process for producing an anomer of a 1-phosphorylated saccharide derivative and process for producing a nucleoside

a technology of saccharide derivative and selective process, which is applied in the direction of sugar derivates, esterified saccharide compounds, organic chemistry, etc., can solve the problems of difficult to establish a general synthetic method for preparing the desired isomer, narrow synthetic process range, poor yield (chem), etc., to achieve good selectivity, improve the inversion rate of the nucleoside, and reduce the cost
US20060094869A1Inactive Publication Date: 2006-05-04MITSUI CHEM INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MITSUI CHEM INC
Publication Date
2006-05-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.
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Description

BACKGROUND OF THE INVENTION

[0001] 1. Field of the Invention

[0002] This invention relates to a process for producing a 1-phosphorylated saccharide derivative. 1-phosphorylated saccharides are widely distributed in the living world, are reaction substrates for a variety of enzymes and are utilized starting materials for preparing useful substances such as drugs and nutritional foods. Synthetic 1-phosphorylated saccharide derivatives have been expected to be used as starting materials for preparing drugs such as antiviral agents and enzyme inhibitors.

[0003] This invention also relates to a process for producing a nucleoside compound used as a starting material or drug substance for medical drugs such as antiviral, anticancer and antisense drugs.

[0004] 2. Description of the Prior Art

[0005] There are known processes for producing a 1-phosphorylated saccharide such as:

[0006] 1) condensation of a 1-bromosaccharide with a silver phosphate salt (J. Biol. Chem., Vol. 121, p. 465 (1937);...

Claims

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