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Compositions and methods of treating burn victims using stem cells

a technology of stem cells and burn victims, applied in the field of burn wound repair, can solve the problems of infection of the wound bed before the repair is complete, failure of the skin graft to properly develop, etc., and achieve the effects of stimulating the reparative and regenerative processes stabilizing the hematological and biochemical indices of the burn victim, and reducing the instances and severity

Inactive Publication Date: 2007-11-29
CAO CALVIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012]The treatment of the burn wound bed with the stem cell containing biological preparation by direct and systemic administration serves to stabilize the hematological and biochemical indices of the burn victim as well as stimulating his reparative and regenerative processes. This in turn reduces the instances and severity of infectious and inflammatory processes and reduces or eliminates the manifestations of secondary complications. Thus the character of the wound healing is changed from that which is typically observed and autoskin engraftment is more readily achieved and autoimmune reactions are reduced or eliminated.

Problems solved by technology

Significant difficulties arise in treatment of such severe burns, including the failure of the skin graft to properly develop and infections of the wound bed before the repair is complete.

Method used

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Examples

Experimental program
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Effect test

example 1

[0025]A patient with severe burns was treated using an embodiment of the inventive method. Stem cells from cord blood were introduced intravenously in the form of an IV drip. On the second day after the burn injury occurred, a decompression dissection of integuments was performed on the patient.

[0026]On the fourth day after the burn injury, the injured skin sites were removed. After removal of the injured skin, a topical preparation containing stem cells, including embryonic epithelial cells and stem cells derived from chorion, was laid on the wound surface.

[0027]On the seventh day after the burn injury, said topical preparation was removed and the sites were cleansed of necrotic suppurative masses. The wound sites were then covered with a thin layer of paste containing fragmented placental tissue. Embryonic fibroblasts were also laid upon the wound surface. Autoplasty was then carried out on top of the paste and embryonic fibroblasts.

[0028]After 30 days, remarkable results were ach...

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Abstract

The present disclosure relates to a method for treating severe burns using a preparation of tissue-derived material, which may comprise stem cells. The method may include systemic administration of stem cells. The method may also include administration of topical preparations of stem cells or tissue extract.

Description

[0001]This application claims the benefit of U.S. Provisional Patent, Application No. 60 / 803,086, filed May 26, 2006, which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to the field of burn wound repair utilizing partially or completely undifferentiated cells with particular emphasis on stem cells such as human embryonic stem cells, cord blood stem cells and placental cells as well as stem cells of other origin both human and non-human. More specifically, the present invention relates to compositions and methods of ensuring successful autoplasty to repair burn wounds.BACKGROUND OF THE INVENTION[0003]Burns are an injury to bodily tissue caused by heat, electricity, chemicals or radiation. There are three levels of burns. First-degree burns affect only the epidermis, i.e. the outer layer of skin, and are characterized by redness, pain, and swelling, but no blisters. The typical sunburn is an example. Second-degree burns (parti...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61K35/44A61K35/50
CPCA61K35/36A61K35/50A61K35/44
Inventor CAO, CALVIN
Owner CAO CALVIN
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