Systems and methods for high speed array printing and hybridization

Inactive Publication Date: 2008-09-18
BIODOT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0020]For purposes of summarizing the invention, certain aspects, advantages and novel features of the invention have been described herein above. Of course, it is to be understood that not necessarily all such advantages may be achieved in accordance with any particular

Problems solved by technology

Another driving force for using small spots has been the cost of the reagents for large spotting libraries.
Research and development (R&D) arrays are typically printed

Method used

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  • Systems and methods for high speed array printing and hybridization
  • Systems and methods for high speed array printing and hybridization
  • Systems and methods for high speed array printing and hybridization

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Embodiment Construction

[0071]The preferred embodiments of the invention described herein relate generally to diagnostic systems and methods and, in particular, to systems and methods for high speed array printing, hybridization, quantitative development and assaying.

[0072]While the description sets forth various embodiment specific details, it will be appreciated that the description is illustrative only and should not be construed in any way as limiting the invention. Furthermore, various applications of the invention, and modifications thereto, which may occur to those who are skilled in the art, are also encompassed by the general concepts described herein.

Some Non-Contact Dispensing Technology Embodiments

[0073]The working drop volume range suitable for production arrays lies in the range of picoliters to nanoliters which, in certain embodiments, is delivered by non contact methods in order to desirably meet process speeds which are suitable for high production throughputs.

[0074]In some embodiments, to...

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Abstract

Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.

Description

CROSS-REFERENCE TO RELATED APPLICATION(S)[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 60 / 881,322, filed Jan. 19, 2007, the entirety of which is hereby incorporated by reference herein.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The invention relates in general to diagnostic systems and methods and, more particularly, to systems and methods for high speed array printing, hybridization, quantitative development and assaying.[0004]2. Description of the Related Art[0005]Diagnostic formats involving microarrays or biochips continue to have a broad range of applications, such as, but not limited to, the fields of genomics and proteomics, among others. These technologies not only relate to the creation of the arrays but also to their processing and assaying such as hybridization. In many cases, valuable reagents need to be effectively utilized in small quantities which can be as low in the picoliter range.[0006]Conventional systems,...

Claims

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Application Information

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IPC IPC(8): C40B60/12C40B60/14
CPCB01J19/0046Y10T436/119163B01J2219/00378B01J2219/00385B01J2219/00527B01J2219/00596B01J2219/00695B01J2219/00698B01J2219/0072B01J2219/00722B01J2219/00725B01L3/0268B01L2300/0838B01L2400/0478B01L2400/065C12M41/00Y10T436/11Y10T436/2575Y10T436/112499B01J2219/0036B01J2219/00529C12Q1/6837C12Q1/686
Inventor TISONE, THOMAS C.EICKHOFF, HOLGER
Owner BIODOT
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