Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds

US20090088433A1Inactive Publication Date: 2009-04-02ALLERGAN INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
ALLERGAN INC
Publication Date
2009-04-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.
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Description

CLAIM OF PRIORITY

[0001] This is a national stage application under 35 U.S.C. § 371 of PCT application PCT / US2006 / 002505, filed on Jan. 25, 2006, which claims the benefit of Provisional Application No. 60 / 647,271, filed on Jan. 26, 2005.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] The present invention relates to methods of treating mammals in need of such treatment with an analgesics composition containing 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides or related compounds.

[0004] 2. Background Art

[0005] 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) was discovered by Vunam, R. R. and Radin, N., Chem. Phys. Lipids, 26, 265-278, 1980. Preparation of PDMP is described in Inokuchi, J. et al., J Lipid Res. 28, 565-571, 1987; Radin, A. et al., NeuroProtocols, 3(2), 145-55, 1993; Radin, A. et al., J. Lipid Res. 36, 611-621, 1995 and U.S. Pat. No. 5,916,911.These derivatives inhibit glucosylceramide (GlcCer) formation ...

Claims

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