Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds
Inactive Publication Date: 2009-04-02
ALLERGAN INC
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[0016]The present invention is directed to methods of using the compounds shown below as analgesics by administering to a mammal, in nee
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However, as far as the present inventors are aware their use a
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[0019]The chemical structures of the compounds used in the methods and compositions of the present invention are provided in the Summary Section of the present application for patent. All of compounds used in the methods and compositions of the present invention have two asymmetric carbons adjacent to one another and therefore, generally speaking, can exist in erythro or threo form, with each of these two forms having dextrorotatory (D) or levorotary (L) enantiomers. Nevertheless, most compounds presently used in the methods and compositions of the present invention are in the threo form which itself can have dextrorotatory (D) or levorotary (L) enantiomers. The scope of the present invention includes use of the threo and erythro isomers, mixtures of erythro and threo isomers, both enantiomers of the isomers in optically pure form, racemic mixtures and mixtures where the enantiomers are not present in equal amounts. In light of the foregoing, it should be clearly understood that the...
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Abstract
The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.
Description
CLAIM OF PRIORITY[0001]This is a national stage application under 35 U.S.C. § 371 of PCT application PCT / US2006 / 002505, filed on Jan. 25, 2006, which claims the benefit of Provisional Application No. 60 / 647,271, filed on Jan. 26, 2005.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to methods of treating mammals in need of such treatment with an analgesics composition containing 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides or related compounds.[0004]2. Background Art[0005]1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) was discovered by Vunam, R. R. and Radin, N., Chem. Phys. Lipids, 26, 265-278, 1980. Preparation of PDMP is described in Inokuchi, J. et al., J Lipid Res. 28, 565-571, 1987; Radin, A. et al., NeuroProtocols, 3(2), 145-55, 1993; Radin, A. et al., J. Lipid Res. 36, 611-621, 1995 and U.S. Pat. No. 5,916,911.These derivatives inhibit glucosylceramide (GlcCer) formation ...
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