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Carbohydrate-metallocene-antimalarial conjugates

a technology of carbohydrate and metalocene, applied in the field of antimalarial compounds, can solve problems such as reducing the ability to effectively combat malaria

Inactive Publication Date: 2010-08-26
ADVANCED APPLIED PHYSICS SOLUTIONS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]An antimalarial conjugate according to a non-limiting embodiment of the present invention may include a metallocene including two cyclopentadienyl rings bound to a central metal atom; a carbohydrate appended to the metallocene; and an antimalarial agent appended to the metallocene, wherein the antimalarial agent has therapeutic properties directed to treating and/or prev...

Problems solved by technology

As a result, such drug resistance has diminished the ability to effectively combat malaria.

Method used

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Embodiment Construction

[0027]It will be understood that when an element or structure is referred to as being “connected,”“coupled,”“bonded,” or “appended” to another element or structure, it may be directly connected, coupled, bonded, or appended to the other element or structure or intervening elements or structures may be present. In contrast, when an element or structure is referred to as being “directly connected,”“directly coupled,”“directly bonded,” or “directly appended” to another element or structure, there are no intervening elements or layers present. Like numbers refer to like elements throughout the specification. As used herein, the term “and / or” includes any and all combinations of one or more of the associated listed items.

[0028]It will be understood that, although the terms first, second, third, etc. may be used herein to describe various elements and / or structures, these elements and / or structures should not be limited by these terms. These terms are only used to distinguish one element ...

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Abstract

An antimalarial conjugate according to a non-limiting embodiment of the present invention may include a metallocene, a carbohydrate, and an antimalarial agent. The metallocene may include two cyclopentadienyl rings bound to a central metal atom. The carbohydrate and the antimalarial agent may be appended to at least one of the cyclopentadienyl rings of the metallocene, wherein the antimalarial agent has therapeutic properties directed to treating and / or preventing malaria. The metallocene may be ferrocene, the carbohydrate may be glucose, and the antimalarial agent may be chloroquine.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application No. 61 / 202,340, filed Feb. 20, 2009, and U.S. Provisional Application No. 61 / 304,598, filed Feb. 15, 2010, the entire contents of each of which are incorporated herein by reference.BACKGROUND[0002]1. Field[0003]Example embodiments of the present invention relate to antimalarial compounds.[0004]2. Description of Related Art[0005]Malaria is a widespread parasitic disease that affects a relatively large population in tropical and subtropical regions. At least four species of the human infecting parasite have been identified, with Plasmodium falciparum being the most lethal. It is estimated that 2 billion people have been exposed to the parasite. About 300-500 million cases of malaria are reported each year, with 1 to 2.7 million people dying from the infection annually. Furthermore, global warming may facilitate the spread of malaria into more temperate r...

Claims

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Application Information

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IPC IPC(8): A61K31/70C07H1/00C08B37/00A61P33/06
CPCA61K31/70C07H23/00A61K47/48092A61K47/549A61P33/06Y02A50/30
Inventor ADAM, MICHAEL J.ORVIG, CHRISSALAS, PALOMAHERRMANN, CHRISTOPH
Owner ADVANCED APPLIED PHYSICS SOLUTIONS
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