Method of forming hollow tubular drug eluting medical devices

a technology of medical devices and hollow tubules, applied in the field of implantable medical devices, can solve the problems of small but dangerous clot formation, biological or pharmacologically active substances not reaching the target site, and limited drug impregnation polymer coatings

Inactive Publication Date: 2011-03-24
MEDTRONIC VASCULAR INC
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, at the conclusion of the elution process, the remaining polymer material in some instances has been linked to an adverse reaction with the vessel, possibly causing a small but dangerous clot to form.
Further, drug impregnated polymer coatings on exposed surfaces of medical devices may flake off or otherwise be damaged during delivery, thereby preventing the biologically or pharmacologically activ

Method used

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  • Method of forming hollow tubular drug eluting medical devices
  • Method of forming hollow tubular drug eluting medical devices
  • Method of forming hollow tubular drug eluting medical devices

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embodiment

Sheet Embodiment

[0055]Another method for forming a stent including hollow struts is described referring to FIGS. 26-30. In this embodiment, rather than forming the stent from a wire bent into a stent pattern, the stent pattern is cut into flat sheets, rolled into a tube, and welded to form a stent with hollow struts. As illustrated schematically in FIG. 26, a first sheet 402 and second sheet 404 sandwich a third sheet 406 therebetween. First and second sheets 402, 404 are made from materials that form a finished stent, such as stainless steel, nitinol, MP35N, etc. Third sheet 406 is made from a material that can be removed from between first and second sheets 402, 404 after forming. For example, the materials described in co-pending U.S. application Ser. No. 12 / 500,359, filed Jul. 9, 2009 and incorporated by reference herein, for the outer member can be used for first and second sheets 402, 404, and the materials described therein for the sacrificial or core member can be used as th...

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Abstract

A method of a forming a hollow, drug-eluting medical device includes utilizing a hollow wire having an outer member and a lumen of the outer member, and filling the lumen with a fluid to form a supported hollow wire. The supported hollow wire is shaped into a stent pattern. Openings are formed through the outer member. The supported hollow wire is processed to remove the fluid from the lumen of the outer member without adversely affecting the outer member, leaving the hollow wire shaped into a stent pattern. The lumen is filled with a biologically or pharmacologically active substance.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Patent Application No. 61 / 244,049 filed Sep. 20, 2009, the contents of which is hereby incorporated by reference.FIELD OF THE INVENTION[0002]The present invention relates to implantable medical devices that release a therapeutic substance and methods of forming such medical devices.BACKGROUND OF THE INVENTION[0003]Drug-eluting implantable medical devices have become popular in recent times for their ability to perform their primary function (such as structural support) and their ability to medically treat the area in which they are implanted.[0004]For example, drug-eluting stents have been used to prevent restenosis in coronary arteries. Drug-eluting stents may administer biologically or pharmacologically active substances such as anti-inflammatory compounds that block local invasion / activation of monocytes, thus preventing the secretion of growth factors that may trigger VSMC prolife...

Claims

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Application Information

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IPC IPC(8): B05D7/00B21F45/00
CPCA61F2/88A61L31/16A61F2240/001A61F2250/0068Y10T29/49995A61F2220/005A61F2220/0058A61F2220/0075A61M31/002A61F2220/0041
Inventor MAUCH, KEVINWARD, SEANJAMOUS, ARAM
Owner MEDTRONIC VASCULAR INC
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