Reducing short-chain fatty acids and energy uptake in obese humans by managing their intestinal microbial communities

a technology of microorganisms and short-chain fatty acids, applied in the field of microbiology and the manipulation of intestinal microorganisms, can solve the problems of increasing health care costs, invasive means, and high risk of numerous adverse events, and achieves rapid h2 oxidation, accelerated bacterial fermentation of carbohydrates, and reduced net energy uptake.

Inactive Publication Date: 2013-09-05
ARIZONA STATE UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Benefits of technology

[0004]The present invention provides for the use of one or more microbiologically-based means to decrease intestinal net fatty acid (e.g., acetate) concentration so that its absorption is decreased, such that the subject's net energy uptake declines. Rapid H2 oxidation by methanogens accelerates the bacterial fermentation of carbohydrates. In the human intestine, the removal of H2 by methanogens leads to increased production of short-chain fatty acids, suc

Problems solved by technology

The health-care costs associated with obesity and obesity-related diseases (e.g., diabetes and other metabolic disease) are enormous and

Method used

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  • Reducing short-chain fatty acids and energy uptake in obese humans by managing their intestinal microbial communities
  • Reducing short-chain fatty acids and energy uptake in obese humans by managing their intestinal microbial communities

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[0008]It should be understood that this invention is not limited to the particular methodology, protocols, and reagents, etc., described herein and as such may vary. The terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention, which is defined solely by the claims.

[0009]As used herein and in the claims, the singular forms include the plural reference and vice versa unless the context clearly indicates otherwise. Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients or reaction conditions used herein should be understood as modified in all instances by the term “about.”

[0010]All patents and other publications identified are expressly incorporated herein by reference for the purpose of describing and disclosing, for example, the methodologies described in such publications that might be used in connection with the present inventio...

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Abstract

The present invention provides for microbial compositions and methods for reducing the concentration of short-chain fatty acids in the gut as a way to reduce energy uptake and manage obesity. More specifically, the invention provides for decreasing short-chain fatty acids available for absorption in the human gut, such as acetate, using one or more of: a probiotic including a homo-acetogenic, acetate oxidizing bacterium that converts acetate to H2; a probiotic including an acetoclastic methanogen; a microbial electrolysis cell comprising a homo-acetogenic bacterium and/or an acetoclastic methanogen; a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or a highly selective antibiotic that targets H2-oxidizing methanogens.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of priority of U.S. Ser. No. 61 / 304,944, filed 16 Feb. 2010, incorporated fully herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to microbiology and the manipulation of intestinal microbiota to modify dietary energy uptake in a human subject. More specifically, the present invention provides means and techniques to scavenge short-chain fatty acids, such as acetate, before they are absorbed in the gut.BACKGROUND[0003]Obesity is epidemic in the U.S. and growing in much of the developed world. The health-care costs associated with obesity and obesity-related diseases (e.g., diabetes and other metabolic disease) are enormous and growing in proportion to the epidemic. The current means to reverse obesity is surgical: gastric bypass or gastric banding. Both means are invasive, expensive, risk numerous adverse events, and may leave permanent sequelae. There is a need for simple, non-invasive means to...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K35/74
CPCA61K31/135A61K31/185A61K31/405A61K35/74A61K35/741A61K45/00A61K2300/00A61P3/00A61P3/04
Inventor RITTMANN, BRUCEKRAJMALNIK-BROWN, ROSAZHANG, HUSENDIBAISE, JOHNCROWELL, MICHAEL
Owner ARIZONA STATE UNIVERSITY
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