Treatment of Cancer WIth Dopamine Receptor Antagonists

a technology of dopamine receptor and dopamine receptor, which is applied in the direction of drug compositions, instruments, library screening, etc., can solve the problems that dopamine receptor antagonists at toxic concentrations to cancer cells have a relatively limited effect on normal stem cells, and achieve the effect of less expression
US20130331381A1Inactive Publication Date: 2013-12-12MCMASTER UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MCMASTER UNIV
Publication Date
2013-12-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and / or subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided.
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Description

RELATED APPLICATIONS

[0001] This application is a 35 USC 371 National Stage Entry of PCT / CA2012 / 000175 filed on Feb. 28, 2012, which claims the benefit of U.S. Provisional Application No. 61 / 447,362, filed on Feb. 28, 2011 each of which is incorporated herein by reference in its entirety.FIELD OF THE DISCLOSURE

[0002] The disclosure relates to methods for the prognosis or treatment of cancer and particularly to methods for the prognosis or treatment of acute myeloid leukemia (AML) that target dopamine receptors.BACKGROUND OF THE DISCLOSURE

[0003] Increasing evidence suggests that cancer / tumor development is due to a rare population of cells, termed cancer stem cells (CSCs) (Dick, 2009; Jordan, 2009; Reya et al., 2001) that are uniquely able to initiate and sustain disease. In addition, experimental evidence indicates that conventional chemotherapeutics, characterized by their ability to inhibit cell proliferation of cancer cell lines (Shoemaker, 2006) or reduce tumor burden in murine mode...

Claims

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