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Plant Parts and Extracts Having Anticoccidial Activity

a technology of plant extracts and anticoccidial activity, which is applied in the direction of antiparasitic agents, biocides, drug compositions, etc., can solve the problems of mortality, oocysts per gram of fecal matter, and lesion score reduction

Inactive Publication Date: 2014-06-12
BANK OF AMERICA N A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent states that certain plant parts and natural extracts from gall nuts of Quercus infectoria, Rhus chinensis, and fruits of Terminalia chebula can reduce the severity of lesions, the number of oocysts in fecal matter, and the rate of mortality. The compounds found to be effective include gallic acid, gallotannins, and hydrolysable tannins. These compounds also have a direct inhibitory effect on the sporozoites of Eimeria, a parasite that causes disease in animals.

Problems solved by technology

The plant parts and natural extracts of gall nuts of Quercus infectoria, Rhus chinensis and fruits of Terminalia chebula result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.

Method used

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  • Plant Parts and Extracts Having Anticoccidial Activity
  • Plant Parts and Extracts Having Anticoccidial Activity
  • Plant Parts and Extracts Having Anticoccidial Activity

Examples

Experimental program
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Effect test

example 1

Efficacy of Quercus infectoria in Controlling Caecal Coccidiosis

[0045]Experimental facility and study design. The screening trial was conducted at a poultry farm facility located in Gummidipundi, India. Straight run commercial hybrid broiler chickens, Gallus domesticus (Var. Vencobb 400) were used for the study. Day old male chicks were procured, weighed individually, wing banded, and randomly segregated into groups. The experimental design is detailed in Table 1.

TABLE 1Study design.CategoryTrial ParameterRearing typeCagesAge of birds at the start of1 day oldthe trialTotal no of Birds56 Number of groups8No of birds / groups7Duration of the trial35 days

[0046]Farm management. Good farm managing practices were followed during the trial. The entire farm and the equipment used for the study were cleaned and disinfected before the arrival of the chicks. The birds were housed in cages organized on concrete flooring and a tray was provided at the bottom of the cages to facilitate collection o...

example 2

Efficacy of Quercus infectoria in Controlling Caecal Coccidiosis

[0061]A 35 day in vivo challenge trial was conducted in broiler birds challenged with Eimeria tenella The treatment groups included, 1) control, uninfected normal birds; 2) negative control, birds infected with E. tenella and fed normal diet without any anticoccidial compounds; 3) positive control, birds infected and fed diet containing Coxistac (anticoccidial agent, Salinomycin) at the recommended dose of 500 g / ton and 4) treatment group including infected birds administered diet containing Q. infectoria gall nut at 500 g / ton dose. No mortality was observed in the positive control group and treatment group supplemented with crude powder of gall nuts of Quercus infectoria. The caecal lesions indicated that the negative control birds were highly infected with an average score of 4 whereas the positive control had score of 0. Birds treated with Quercus infectoria showed results similar to the positive control (0). Q. infe...

example 3

Efficacy of Water Extracts of Quercus infectoria in Controlling mixed Infection of Coccidiosis

[0069]Efficacy of Q. infectoria crude powder in controlling mixed infection of coccidiosis in broiler birds was evaluated. A 35 day in vivo trial was conducted wherein the birds were challenged with field strains of mixed culture of oocysts of the species E. tenella, E. acervulina and E. maxima. The mixed culture of oocysts was provided by Department of parasitology, Tamil Nadu Veterinary Research Institute, Namakkal, India. The oocysts culture was a mixture of E. tenella, E. acervulina and E. maxima isolated from feces of birds with clinical coccidiosis infection. Virulence of the oocysts obtained was evaluated in broiler birds and the dosage of the oocysts was finalized to be 5×105 based on the concentration that yields a lesion score of 3 and above for all the tested oocysts, E. tenella, E. maxima and E. acervulina.

a. The screening trial was conducted at Kemin's in-house R&D poultry far...

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Abstract

Natural plant parts and extracts of plants selected from the group consisting of Quercus infectoria, Rhus chinensis and Terminalia chebula containing compounds such as gallic acid, derivative of gallic acid, gallotannins and hydrolysable tannins have been found to control coccidiosis in poultry and, more specifically, coccidiosis caused by Eimeria spp. The plant parts and natural extracts result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.

Description

[0001]This application claims priority to U.S. Patent Application Ser. No. 61 / 664,795, filed Jun. 27, 2012 and Indian Application No. 177 / DEL / 2013, filed Jan. 23, 2013, both of which are incorporated herein by this reference.BACKGROUND OF THE INVENTION[0002]The present invention relates generally to the control of coccidiosis and, more specifically, to the application of plant parts, plant extracts and compounds to control coccidiosis in poultry and other animals.[0003]Coccidiosis is a major disease in the poultry industry and according to a recent survey, it is estimated that the global impact is greater than $3 billion USD annually (worldpoultry.net / Broilers / Health / 2009 / 9 / In-ovo-vaccination-against-coccidiosis-WP006949W / —accessed Jun. 18, 2013). Coccidiosis is caused by a protozoan parasite, namely Eimeria, belonging to the phylum Apicomplexa, and the family Eimeriidae (Clare, R. A and Danforth, H. D (1989). Major histocompatibility complex control of immunity elicited by genetica...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/49A61K36/185A61K36/22
CPCA61K36/49A61K36/22A61K36/185A61K31/192A61P33/02A61P33/10A61K2121/00
Inventor THANGAVEL, GOKILAMUKKALIL, RAJALEKSHMICHIRAKKAL, HARIDASANKURIAN, HANNAH
Owner BANK OF AMERICA N A
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