Method for the diagnosis, prognosis, and tratment of cancer metastasis

a cancer metastasis and prognosis technology, applied in the field of cancer metastasis diagnosis, prognosis and treatment, can solve problems such as cell change, achieve the effects of increasing the expression level of c-maf, reducing the risk of metastatic cancer, and inhibiting expression
US20160040247A1Inactive Publication Date: 2016-02-11FUNDACIO INST DE RECERCA BIOMEDICA (IRB BARCELONA) +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
FUNDACIO INST DE RECERCA BIOMEDICA (IRB BARCELONA)
Publication Date
2016-02-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

This study describes a method to determine the likelihood of the development of metastasis in a subject suffering from cancer, in addition to a method to design a customized therapy in a subject suffering from cancer, in particular breast, colon, lung, kidney and thyroid cancer, based on the determination of the expression level of one or more genes whose expression is modulated by an increase in c-MAF expression. It also describes a method for the identification of marker genes with a propensity for metastatic cancer based on inducing the modulation of the c-MAF expression Finally, the use of PTHLH and PODXL inhibitors and RERG activators in the treatment and / or prevention of the cancer, in particular breast, colon, lung, kidney and thyroid cancer.
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Description

OBJECTS OF THE INVENTION

[0001] This invention relates to methods to determine the likelihood a subject suffering from cancer, in particular breast, colon, lung, kidney or thyroid cancer, will develop a metastasis, in addition to methods for the creation of customized therapies for a subject suffering from cancer, in particular breast, colon, lung, kidney or thyroid cancer. Such methods consist of determining the expression level of a set of genes whose expression is related to the c-MAF gene expression. The invention also involves the use of PTHLH and PODXL inhibitors and RERG activators in the treatment and / or prevention of the metastatic cancer, in particular breast, colon, lung, kidney or thyroid cancer.BACKGROUND OF THE INVENTION

[0002] Breast cancer is the second most common type of cancer worldwide (10.4%; after lung cancer) and the fifth most common cause of death by cancer (after lung cancer, stomach cancer, liver cancer and colon cancer). Is breast cancer the most common cause...

Claims

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