Agents and methods for modulating the sensory impact of tobacco or herbal smoke

Abstract

A combustible device includes a wrapper, tobacco disposed in the wrapper, and an agent that activates a TRPA1 channel disposed in the wrapper.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional App. No. 62 / 398,875, filed Sep. 23, 2016, which is hereby incorporated by reference in its entirety.BACKGROUND

[0002] Tobacco smoke is a causal risk factor for cancer (especially but not exclusively lung cancer), cardiovascular disease, and lung dysfunction, including chronic obstructive pulmonary disease (COPD). Despite the recognized and widely known hazards of tobacco smoke, the addictive properties of cigarettes and other tobacco products have been a barrier to smoking cessation or reduction. There are a number of proposed strategies for reducing the harm associated with smoking. One attempted strategy has been to produce cigarettes with low tar and nicotine delivery during smoking, intended to be below the threshold for establishment or maintenance of nicotine addiction. Such “light” cigarettes have had little impact on smoking-related illnesses, in part due to low consumer satisfact...

Examples

example 1

[0058]Aframomum melegueta seeds (200 grams), and powdered galangal root, or ethanolic galangal extracts, were pulverized in a coffee grinder and extracted through a heated extraction process with ethanol for 3 hours. The extract was filtered in three separate steps. Using a syringe and needle, 0.1 ml was injected into a light cigarette, withdrawing the needle while dispensing the extract from the syringe down the length of the tobacco column. After being allowed to dry, the cigarette displayed an intensified throat sensation, mimicking a key element of the sensory impact of a stronger cigarette.

example 2

[0059]Aframomum melegueta seeds (2.4 kg), thyme leaves (7.4 kg), rosemary (6.6 kg), and powdered galangal root (8.1 kg), were pulverized in a coffee grinder and extracted through a heated extraction process with 106 liters of methanol for 3 hours. The extract was filtered in three separate steps. This extract was applied to tea leaves as a tobacco substitute. Application was by fine spray over the non-tobacco herbal cut-rag which was then mixed and tumbled to coat evenly. The treated cut-rag was dried in a commercial grade oven for 4 hours. Following the drying process, the cut-rag was sprayed with propylene glycol to reach a moisture level of approximately 18%. The non-tobacco herbal cut-rag was manufactured into cigarettes on a Hauni Protos high speed cigarette making line. The cigarettes displayed an intensified throat sensation, mimicking a key element of the sensory impact of a nicotine containing tobacco cigarette.

example 3

[0060]Aframomum melegueta seeds (200 grams), and powdered galangal root, or ethanolic galangal extracts, were pulverized in a coffee grinder and extracted through a heated extraction process with methanol for 3 hours. The extract was filtered in three separate steps. This extract was applied to a very low nicotine (VLN) tobacco cut-rag with less than 0.04% nicotine. Application was by fine spray over the cut-rag which was then mixed and tumbled to coat evenly. The treated cut-rag was dried in a commercial grade oven for 4 hours. Following the drying process, the cut-rag was sprayed with propylene glycol to reach a moisture level of approximately 18%. The VLN cut-rag was hand-rolled into cigarettes, which displayed an intensified throat sensation, mimicking a key element of the sensory impact of a tobacco cigarette with regular level of nicotine content.

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional App. No. 62 / 398,875, filed Sep. 23, 2016, which is hereby incorporated by reference in its entirety.BACKGROUND

[0002] Tobacco smoke is a causal risk factor for cancer (especially but not exclusively lung cancer), cardiovascular disease, and lung dysfunction, including chronic obstructive pulmonary disease (COPD). Despite the recognized and widely known hazards of tobacco smoke, the addictive properties of cigarettes and other tobacco products have been a barrier to smoking cessation or reduction. There are a number of proposed strategies for reducing the harm associated with smoking. One attempted strategy has been to produce cigarettes with low tar and nicotine delivery during smoking, intended to be below the threshold for establishment or maintenance of nicotine addiction. Such “light” cigarettes have had little impact on smoking-related illnesses, in part due to low consumer satisfact...

Examples

example 1

[0058]Aframomum melegueta seeds (200 grams), and powdered galangal root, or ethanolic galangal extracts, were pulverized in a coffee grinder and extracted through a heated extraction process with ethanol for 3 hours. The extract was filtered in three separate steps. Using a syringe and needle, 0.1 ml was injected into a light cigarette, withdrawing the needle while dispensing the extract from the syringe down the length of the tobacco column. After being allowed to dry, the cigarette displayed an intensified throat sensation, mimicking a key element of the sensory impact of a stronger cigarette.

example 2

[0059]Aframomum melegueta seeds (2.4 kg), thyme leaves (7.4 kg), rosemary (6.6 kg), and powdered galangal root (8.1 kg), were pulverized in a coffee grinder and extracted through a heated extraction process with 106 liters of methanol for 3 hours. The extract was filtered in three separate steps. This extract was applied to tea leaves as a tobacco substitute. Application was by fine spray over the non-tobacco herbal cut-rag which was then mixed and tumbled to coat evenly. The treated cut-rag was dried in a commercial grade oven for 4 hours. Following the drying process, the cut-rag was sprayed with propylene glycol to reach a moisture level of approximately 18%. The non-tobacco herbal cut-rag was manufactured into cigarettes on a Hauni Protos high speed cigarette making line. The cigarettes displayed an intensified throat sensation, mimicking a key element of the sensory impact of a nicotine containing tobacco cigarette.

example 3

[0060]Aframomum melegueta seeds (200 grams), and powdered galangal root, or ethanolic galangal extracts, were pulverized in a coffee grinder and extracted through a heated extraction process with methanol for 3 hours. The extract was filtered in three separate steps. This extract was applied to a very low nicotine (VLN) tobacco cut-rag with less than 0.04% nicotine. Application was by fine spray over the cut-rag which was then mixed and tumbled to coat evenly. The treated cut-rag was dried in a commercial grade oven for 4 hours. Following the drying process, the cut-rag was sprayed with propylene glycol to reach a moisture level of approximately 18%. The VLN cut-rag was hand-rolled into cigarettes, which displayed an intensified throat sensation, mimicking a key element of the sensory impact of a tobacco cigarette with regular level of nicotine content.

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