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Compositions comprising dead sea water and polysaccharides and uses thereof as skin protectants

a technology of dead sea water and polysaccharides, which is applied in the direction of drug compositions, dermatological disorders, anti-noxious agents, etc., can solve the problems of xerotic skin, various illnesses, and overall detriment to human skin and body health, and achieve the effect of protecting against environmental pollutants

Inactive Publication Date: 2019-07-18
DEAD SEA LAB LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a combination of Dead Sea extract and a specific polysaccharide that protects against various pollutants, including ozone and heavy metals. The inventors found that the combination was more effective than using either ingredient alone. The compositions can be used in different concentrations and ratios to provide selective protection against specific pollutants. The invention also provides a use of the composition for manufacturing skincare products that protect against pollution and specific pollutants.

Problems solved by technology

Air pollution, caused by industry, vehicle fumes, cigarette smoke and other sources together with solar radiation (ultra violet, UV) are known to have a detrimental effect on human skin and body health altogether and lead to various illnesses.
Pollution may be the source of cutaneous stress as pollutants can react with skin, alter skin barrier, penetrate through skin barrier and cause damage such as oxidation and inflammation due to the reaction with the skin cells and other cell bio-molecules therein such as skin proteins, lipids and DNA.
The effect of pollutants on the skin may result with xerotic skin, sensitive skin, premature and accelerated aging of the skin for example wrinkle formation, abnormal pigmentation, skin dryness and more.
The natural skin ability of self-defense against pollution risks is limited.
However, prolonged and repetitive exposure to high levels of pollutants impairs the skin's natural defense capacity.

Method used

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  • Compositions comprising dead sea water and polysaccharides and uses thereof as skin protectants
  • Compositions comprising dead sea water and polysaccharides and uses thereof as skin protectants
  • Compositions comprising dead sea water and polysaccharides and uses thereof as skin protectants

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of the Compositions of the Present Disclosure

Dead Sea Extract

[0272]In the present disclosure a commercial preparation of Dead Sea minerals (DSM) referred to herein as “Osmoter” was used. The preparations is also known as “Maris Sal” or “Maris Aqua” (Dead Sea Water, DSW) (Source: Geological Survey—Ministry of National Infrastructures, State of Israel, especially for Ahava-Dead Sea Laboratories CAS # INCI Monograph ID: 11089).

[0273]The “Osmoter” solution has the following composition:

Salt normality (N)Salt normality (N)Na0.118(2.720 g / l)Rb3.5 × 10−6(−4 g / l)K0.054(2.100 g / l)Sb−7(−5 g / l)Ca0.873(35.000 g / l)Sr7.6 × 10−3(0.670 g / l)Mg3.815(92.700 g / l)V−5(Ba6.6 × 10−5(0.009 g / l)Th−8(−5 g / l)Cd−7(−5 g / l)U−8(−5 g / l)Co−5(Zn−5(Cu−5(Cl9.75(346 g / l)Cr−4(Br0.175(14 g / l)Fe−5(B0.011(0.120 g / l)Li5.76 × 10−3(0.040 g / l)As2.7 × 10−5(0.002 g / l)Mn1.82 × 10−4(0.010 g / l)I6.30 × 10−7(8 × 10−8 g / l)Mo−6(−4 g / l)SiO2−4(Ni−5(SiO4−3(Pb−8(−5)

[0274]Solutions comprising Dead Sea Minerals / Water were prepared...

example 2

Laboratory Pollution Models in Skin

[0279]Osmoter and Pollustop® were tested alone and in combination for anti-pollution activity using two complementary laboratory models:

Model 1: Ozone exposure, on reconstructed skin equivalents (full thickness tissue).

Model 2: Mixture of pollutants containing heavy metals and atmospheric PM, on reconstructed epidermis.

[0280]Both pollution models were based on reconstructed epidermis [manufacture by MatTek corporation, USA, for the ozone exposure model and by CellSystem, Germany, (Troisdorf, Batch 100-AF0828-1) for the pollutant mixture model]. The reconstructed epidermis represents a tridimensional artificial system of human epidermis, comprising normal human epidermal keratinocytes, growing as an integrated three-dimensional cell culture model, perfectly mimicking the human skin in vitro. The reconstructed epidermis exhibits normal barrier functions.

Tissue Preparation

[0281]Upon arrival, the epidermis tissues were stored at 4° C. until used. Prior...

example 3

Testing the Selectivity of the Compositions Against Specific Pollutants

[0310]As noted herein above, the level of pollution and pollutant concentration may vary throughout the time of the day, by season, geographic location and according to the level of human activity. The necessity of protection of the skin against pollutants may vary accordingly.

[0311]For example, while protection against specific pollutant or specific group of pollutants may be necessary at specific geographic location, a different protection might be necessary at another geographic location. The same applies to different seasons and different times of the day.

[0312]Thus, while at times broad protection against a variety of pollutants might be necessary, at times protection might be needed only against specific one or more pollutants.

[0313]For the purpose of screening specific compositions comprising the active ingredients of the present invention (i.e., DSW and polysaccharide) which possess selective protection p...

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PUM

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Abstract

Provided are compositions including at least one Dead Sea extract and at least one polysaccharide, wherein the repeating unit of said polysaccharide is a tetrasaccharide consisting of two D-glucose residues, one L-fucose residue and one D-glucuronic acid residue. Further provided are formulations including the compositions and their uses as skin protectants against pollution.

Description

FIELD OF THE INVENTION[0001]This invention relates to compositions comprising Dead Sea extract in combination with one or more polysaccharides for use as skin protectants against pollution.BACKGROUND OF THE INVENTION[0002]The World Health Organization (WHO) defines pollution as contamination of the indoor or outdoor environment by any chemical, physical or biological agent that modifies the natural characteristics of the atmosphere.[0003]The evolution of our lifestyle and the increasing urbanization during the past years amplify the risks associated with pollution, making the pollution one of the major sources of concern for health and beauty.[0004]Air pollution, caused by industry, vehicle fumes, cigarette smoke and other sources together with solar radiation (ultra violet, UV) are known to have a detrimental effect on human skin and body health altogether and lead to various illnesses.[0005]Pollution may be the source of cutaneous stress as pollutants can react with skin, alter sk...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/96A61K8/73A61K31/715A61K35/08A61Q17/00A61P29/00A61P39/00A61P17/00
CPCA61K8/965A61K8/73A61K31/715A61K35/08A61Q17/00A61P29/00A61P39/00A61P17/00
Inventor PORTUGAL COHEN, MEITALORON, MIRIAMCOHEN, DRORMAOR, ZEEVI
Owner DEAD SEA LAB LTD
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