Herbal composition for treating anxiety related conditions
a technology for anxiety disorders and herbal compositions, applied in the field of herbal compositions based on herbal mixtures, can solve the problems of low success rate of treating anxiety disorders, chronic nature of anxiety disorders requires long-term treatment, and limited efficacy of current treatments for anxiety disorders in a considerable proportion of patients
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example 1
Measurement of Anxiety-related Behavior in Rodents—The Elevated Plus-Maze (EPM)
[0100]A well known measurement of anxiety-related behavior in rodents is the Elevated Plus-Maze (EPM). The test setting consists of a plus-shaped apparatus with two open and two closed arms, each with an open roof, elevated 40-70 cm from the floor. The model is based on rodents' aversion of open spaces. This aversion leads to the behavior termed thigmotaxis, which involves avoidance of open areas by confining movements to enclosed spaces or to the edges of a bounded space. In EPM this translates into a restriction of movement to the enclosed arms. Anxiety reduction in the plus-maze is indicated by an increase in the time spent in the open arms.
[0101]BALB mice (a strain known to exhibit increased anxiety-like behavior) were treated either with the adaptogenic composition of the invention (namely a mixture of Hawthorn fruit, wheat grain, Lilly Bulb and Zizyphi Jujubae in equal ratios) (10 mg / kg / day), with c...
example 2
Measurement of Anxiety-related Behavior after Acute Episodic Stress
[0102]Another study conducted on BALB mice was aimed to examine the anxiolytic effect after acute episodic stress during the treatment and following 3 weeks of treatment. Mice were treated through i.p. injection with the adaptogenic mixture (15 mg / kg / day), escitalopram (15 mg / kg / day) or vehicle. The acute stress was obtained with Yohimibine i.p injection, a drug known to activate a stress-reaction (Vasa et al., 2009). Results demonstrate an anxiolytic effect of the adaptogenic treatment in the Elevated plus maze and in the novel open field (see FIG. 2).
[0103]The Novel Open Field is another well-established test of anxiety-related behavior in rodents. The Open Field area generally consists of an empty and bright square arena, surrounded by walls to prevent the rodent from escaping. The rodent is usually placed in the center of the arena and its behavior recorded over a chosen period. The Novel Open Field task approach...
example 3
Assessment of Stress Responses Following Chronic Stress
[0104]Animals
[0105]ICR outbred mice, purchased from ‘Harlan, Israel’, were bred and kept in an approved animal house at the ‘Tel-Aviv Academic College’ vivarium. The animals were housed in standard laboratory cages (transparent polycarbonate cages, Makrolon type III, 37.5×22×5 cm) in a colony room (T, 22±2° C.; relative humidity, ±60%). The floors of the cages were covered with a 2-3 cm thick layer of wood shavings. All procedures were carried out in accordance with the Israeli Council for Experimentation on Animal Subjects (ICEAS) institutionally approved protocols. Mice were given free access to food and soured water and were maintained on a 12 h light / dark cycle (lights off at 7 AM). All experiments were approved by the international committee for animal care and use in Israel (MTA-0001-4-07-10).
[0106]Maternal Separation (MS)
[0107]On the day of parturition, PND 0 (postnatal day), litters were randomly assigned to undergo MS o...
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