Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparation of N-acetyl cysteine amide

a technology of n-acetyl cysteine and amide, which is applied in the field of preparation of n-acetyl cysteine amide, can solve the problems of limited therapeutic usefulness of gsh precursors, and achieve the effects of high chemical yield and high chemical and enantiomeric purity

Active Publication Date: 2017-09-19
NACUITY PHARMA INC
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, directly administered, these GSH precursors have limited therapeutic usefulness because of their limited bioavailability.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparation of N-acetyl cysteine amide
  • Method for preparation of N-acetyl cysteine amide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

Experiments

[0028]The following procedures may be employed for the preparation of the compound of the present invention. The starting materials and reagents used in preparing these compounds are either available from commercial suppliers such as the Aldrich Chemical Company (Milwaukee, Wis.), Bachem (Torrance, Calif.), Sigma (St. Louis, Mo.), or are prepared by methods well known to a person of ordinary skill in the art, following procedures described in such references as Fieser and Fieser's Reagents for Organic Synthesis, vols. 1-17, John Wiley and Sons, New York, N.Y., 1991; Rodd's Chemistry of Carbon Compounds, vols. 1-5 and supps., Elsevier Science Publishers, 1989; Organic Reactions, vols. 1-40, John Wiley and Sons, New York, N.Y., 1991; March J.: Advanced Organic Chemistry, 4th ed., John Wiley and Sons, New York, N.Y.; and Larock: Comprehensive Organic Transformations, VCH Publishers, New York, 1989.

[0029]Preparation of N-Acetyl Cysteine Amide (NACA)

[0030]

[0031]N-Acetyl Cystei...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pressureaaaaaaaaaa
organicaaaaaaaaaa
temperatureaaaaaaaaaa
Login to View More

Abstract

The present application discloses an efficient process for the preparation of N-acetyl-L-cysteine amide (NACA) starting with N-acetyl-L-cysteine.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is U.S. 371 National Phase Application of PCT No. PCT / US2015 / 022910, international filing date of 27 Mar. 2015, title, METHOD FOR THE PREPARATION OF N-ACETYL CYSTEINE AMIDE, and claims benefit of U.S. Provisional U.S. Ser. No. 61 / 972,133, filed on 28 Mar. 2014.STATEMENT OF FEDERALLY FUNDED RESEARCH[0002]None.BACKGROUND OF THE APPLICATION[0003]Decreased glutathione (GSH) availability in the brain is linked to several neurodegenerative diseases including Parkinson's disease. Means of restoring GSH levels include delivery of GSH precursors, e.g. N-acetyl cysteine, N-acetyl cysteine amide (NACA) or cysteine to the brain. However, directly administered, these GSH precursors have limited therapeutic usefulness because of their limited bioavailability.[0004]The preparation of N-acetyl cysteine amide (NACA) has been previously described in J. Med. Chem. 1967, 10, 1172-1176.[0005]There is a need for developing an efficient method ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(United States)
IPC IPC(8): C07C311/29A61K31/16C07C321/00A61K31/195A61K38/04A61K31/095A61K31/198
CPCA61K31/195A61K31/095A61K31/16A61K31/198A61K38/04C07C311/29C07C321/00C07C319/12C07C323/59C07C323/60
Inventor WARNER, JOHN C.CHERUKU, SRINAVASATHOTA, SAMBAIAHLEE, JOHN W.
Owner NACUITY PHARMA INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com