Isobutylgaba and its derivatives for the treatment of pain

Inactive Publication Date: 2010-11-09
WARNER-LAMBERT CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012]The more preferred compounds of the invention are (S)-3-(ami...

Problems solved by technology

Advantages of the use of the compounds includes the finding that repeated use does...

Method used

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  • Isobutylgaba and its derivatives for the treatment of pain
  • Isobutylgaba and its derivatives for the treatment of pain
  • Isobutylgaba and its derivatives for the treatment of pain

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Embodiment Construction

[0026]The instant invention is a method of using a compound of Formula I above as an analgesic in the treatment of pain as listed above. Pain such as inflammatory pain, neuropathic pain, cancer pain, postoperative pain, and idiopathic pain which is pain of unknown origin, for example, phantom limb pain are included especially. Neuropathic pain is caused by injury or infection of peripheral sensory nerves. It includes, but is not limited to pain from peripheral nerve trauma, herpes virus infection, diabetes mellitus, causalgia, plexus avulsion, neuroma, limb amputation, and vasculitis. Neuropathic pain is also caused by nerve damage from chronic alcoholism, human immunodeficiency virus infection, hypothyroidism, uremia, or vitamin deficiencies. Neuropathic pain includes, but is not limited to pain caused by nerve injury such as, for example, the pain diabetics suffer from.

[0027]The conditions listed above are known to be poorly treated by currently marketed analgesics such as narcoti...

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PUM

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Abstract

The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy.

Description

[0001]Notice: more than one reissue application has been filed for the reissue of U.S. Pat. No. 6,001,876. The reissue applications: are U.S. application Ser. No. 12 / 700,968 (filed Feb. 5, 2010), which is a continuation of the present application; and, the present application.<?insert-end id="INS-S-00001" ?>[0002]This application claims benefit of Provisional application Ser. No. 60 / 022,337, Jul. 24, 1996.BACKGROUND OF THE INVENTION[0003]The present invention is the use of analogs of glutamic acid and gamma-aminobutyric acid (GABA) in pain therapy, as the compounds exhibit analgesic / antihyperalgesic action. Advantages of the use of the compounds includes the finding that repeated use does not lead to tolerance nor is there a cross-tolerance between morphine and the compounds.[0004]The compounds of the invention are known agents useful in antiseizure therapy for central nervous system disorders such as epilepsy, Huntington's chorea, cerebral ischemia, Parkinson's disease, tardi...

Claims

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Application Information

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IPC IPC(8): A61K31/195A61K31/197A61P25/04A61K31/198A61P29/00
CPCA61K31/197A61P23/00A61P25/04A61P29/00A61K31/19
Inventor SINGH, LAKHBIR
Owner WARNER-LAMBERT CO
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