12 results about "Auto immunite" patented technology

The invention discloses a comprehensive automatic immunization all-in-one machine which comprises a machine base, and a controller, a poultry intramuscular injection device, a poultry neck posterior subcutaneous injection device, a poultry wing membrane stabbing device and a poultry eye drop immunization device which are arranged on the machine base, the poultry intramuscular injection device, the poultry posterior-neck subcutaneous injection device, the poultry eye drop immunization device and the poultry wing membrane stabbing device are controlled by the controller, the poultry intramuscular injection device is used for performing intramuscular injection on poultry, and the poultry posterior-neck subcutaneous injection device is used for performing posterior-neck subcutaneous injection on poultry; the poultry eye dropping immunization device is used for carrying out eye dropping operation on poultry, and the poultry wing membrane stabbing device is used for carrying out stabbing injection on wing membranes of the poultry. The situation that traditional artificial immunization is high in labor intensity and low in efficiency is changed, the work efficiency of immunization inoculation is greatly improved, and meanwhile the equipment purchase cost and the site occupied area are reduced; moreover, the poultry grabbing frequency is reduced, the irritability is reduced, and the timeliness and continuity of immunization are improved.

An automatic immunoassay system is provided to an automatic immunoassay apparatus and includes a well cartridge provided with a plurality of wells in which a tip mounted on the automatic immunoassay apparatus is sequentially dipped, a cartridge loading mechanism coupled to a lower portion of the well cartridge to couple the well cartridge to the holding plate, a light source unit disposed at one side of the cartridge unit to emit light to the wells, a sensing unit disposed at the other side of the cartridge unit to detect a fluorescence signal generated by light delivered to the wells, and an assay unit analyzing the fluorescence signals detected by the sensing unit.

This invention discloses a high-throughput automated immunofluorescence staining device and its staining method. The device includes a liquid injection motion module, a reaction chamber module, a supply and waste collection module, and a control system. The liquid injection motion module includes an X-axis beam and a pipetting and auxiliary material robotic arm, which are driven in parallel to achieve sequential operation. The reaction chamber module includes a temperature-controlled station, a low-temperature reagent storage unit, and an auxiliary material supply unit. The supply and waste collection module includes a waste removal and cleaning unit and an auxiliary material waste collection unit. This invention achieves a 96-station array through a temperature-controlled reaction station, combined with the dual-drive parallel operation of the pipetting and auxiliary material robotic arms, eliminating action waiting time and significantly improving throughput. The use of a closed semiconductor cooling component linked with an automatic flip-top mechanism ensures uniform reagent activity over a long period. A plate-mounted small vacuum pump drives a rigid pipeline with deep-hole waste suction, combined with high-flow-rate wide-area spraying, to thoroughly remove waste liquid and reduce cross-contamination. This achieves full-process automation, significantly improving staining quality and efficiency.

The invention discloses a full-automatic immunofluorescence slide staining system and method, and relates to the technical field of slide staining machines. A central control system as well as a sample processing module, a reagent loading module, a cleaning needle module, a sealing module, a fluorescence imaging module and an antigen sheet loading module which are in signal interaction connection with the central control system are arranged on the operating table; the sample processing module is provided with a plurality of independent sample needle modules, and each independent sample needle module is provided with an independent Z-axis driving mechanism and an independent Y-axis driving mechanism. Cooperative operation of all the modules is planned through a central control system, a full-process automatic closed loop from sample code scanning, dilution, incubation, cleaning, secondary antibody loading to sheet sealing, fluorescence imaging and preliminary interpretation is formed, the limitation of traditional manual operation and function fragmentation of existing equipment is thoroughly eliminated, all experiment links do not need to be connected manually, and the working efficiency is improved. The manual dependence degree is obviously reduced, and the detection efficiency of large-batch samples is effectively improved.

This invention provides a fully automated immunoassay analyzer, comprising: a base, a reaction disk for carrying multiple immunochromatographic test strips installed inside the base, a sample processing area for processing samples installed on the base, and a moving arm assembly movably installed on the base for driving a pipette arm to perform liquid pipetting, mixing, and spotting operations in the sample processing area. Compared with the prior art, this invention has the following advantages: by setting up the moving arm assembly, in conjunction with the pipette arm and negative pressure nozzle, its automated operation can simultaneously perform multiple sample single detection, single sample multiple detection, or multiple sample multiple detection, with high throughput, making up for the insufficient throughput of existing manual experiments. Automated sample pretreatment and automatic recycling of waste after experiments avoid manual errors and are convenient and pollution-free.

This invention discloses a fully automated immunofluorescence staining system and method, relating to the field of staining machine technology. The system includes an operating table equipped with a central control system and, through signal interaction with the central control system, a sample processing module, a reagent loading module, a cleaning needle module, a mounting module, a fluorescence imaging module, and an antigen loading module. The sample processing module is configured with several independent sample needle modules, each equipped with an independent Z-axis drive mechanism and an independent Y-axis drive mechanism. The central control system coordinates the operation of all modules, forming a fully automated closed loop from sample scanning, dilution, incubation, cleaning, secondary antibody loading to mounting, fluorescence imaging, and preliminary interpretation. This completely eliminates the limitations of traditional manual operation and the fragmented functionality of existing equipment, eliminating the need for manual coordination between experimental steps, significantly reducing reliance on manual labor, and effectively improving the detection efficiency of large batches of samples.

The present invention provides a slide for precision management, which can estimate the presence or absence of an abnormality in an automatic immunostaining device and can estimate the cause of the abnormality when the abnormality has occurred. The slide for precision management is characterized by having a spot (antigen (-)) that does not contain an antigen, a spot (fixed (-) / antigen (+)) that contains an antigen without applying histological immobilization, and a spot (fixed (+) / antigen (+)) that contains an antigen with applying histological immobilization.

The invention discloses a full-automatic immunohistochemical staining machine, and belongs to the technical field of immunohistochemical staining. The full-automatic immunohistochemical staining machine comprises a base, a machine shell and a machine cover, the machine shell and the machine cover are arranged above the base, the machine cover is movably connected with the machine shell, a slide glass assembly is arranged above the base, and a linear module and a tissue treatment assembly are arranged on one side of the interior of the machine shell; the slide glass assembly comprises a rotating shaft movably arranged above the base, a spiral plate fixedly installed on the side face of the rotating shaft and a plurality of fixed plate assemblies evenly arranged on the upper surface of the spiral plate at intervals, an air inlet pipe is arranged on one side of the base, and an air outlet pipe is arranged on one side of the upper portion of the machine shell; according to the invention, the stator assembly is spirally arranged, so that the stator assembly is more dispersedly arranged in the device, the external environment temperature is prevented from interfering the temperature detection of the stator assembly on the slide, the accurate detection of the temperature of the slide on the stator assembly by the stator assembly is realized, and the accurate heating of the slide is realized.

The invention relates to the technical field of medical detection, in particular to an antibody combination for detecting spermatogenic cells, a kit and application of the antibody combination. The antibody combination comprises an antibody of a zinc finger transcription factor 4, an antibody of a conjugation complex protein 3 and an antibody of zona pellucida binding protein. Specific recognition and semi-quantitative analysis of spermatogenic cells of all levels in samples are realized through standardized pretreatment, full-automatic immunohistochemical staining and digital image analysis for different types of samples; the method breaks through the technical bottlenecks that the traditional HE staining or Wright-Giemsa staining method is strong in subjectivity, difficult to distinguish cells with similar forms and greatly influenced by cell states and staining effects, and provides an efficient detection means for accurate pathological typing, spermatogenic function evaluation and dynamic curative effect monitoring of male infertility.

The utility model provides full-automatic immunofluorescence labeling equipment. The full-automatic immunofluorescence labeling equipment comprises a control mechanism, a power mechanism, a reagent suction mechanism and a sample labeling mechanism, the power mechanism is electrically connected with the control mechanism, the reagent suction mechanism and the sample marking mechanism are both connected with the power mechanism, and the power mechanism is used for driving the reagent suction mechanism to suck a reagent required by immunofluorescence labeling and conveying the reagent required by immunofluorescence labeling to the sample marking mechanism; the sample labeling mechanism is used for adding the reagent required by immunofluorescence labeling into the corresponding culture dish to be labeled, so that the step of automatically performing immunofluorescence labeling is realized, and the problems of low immunofluorescence labeling efficiency, poor repeatability and low result reliability caused by manual labeling are avoided.

The invention discloses a multi-channel parallel detection method of a full-automatic immunoblotting instrument, and relates to the field of biotechnology detection. The problems that a traditional immunoblotting method needs multiple incubation, operation is tedious and time-consuming, and signal crosstalk and inaccurate quantification are caused by emission spectrum overlapping of a multi-standard method based on spectrum distinguishing are solved. The method comprises the following steps: preparing a marker combination with mutually distinguished fluorescence lifetime, carrying out one-time synchronous incubation combination, carrying out pulse laser scanning excitation, collecting signals in a discontinuous time gate by adopting time gate control detection to obtain a four-dimensional detection data set, and finally carrying out decoupling operation based on known fluorescence lifetime characteristics to obtain a four-dimensional detection result. And a super-resolution protein distribution diagram is further generated through regularization optimization, and signal separation is realized according to life difference, so that super-resolution quantitative expression quantity distribution of each target protein is synchronously obtained in one-time detection, high-throughput and high-accuracy multi-target protein parallel detection is realized, and spectral crosstalk is effectively avoided.

The present invention discloses a fully automatic immunohistochemical staining device, which includes a micro reagent sampling mechanism and a plurality of incubation units. The incubation unit includes a heating mechanism, a large reagent sampling mechanism, a cleaning mechanism, a waste suction mechanism, a coverslip conversion mechanism and a transverse movement mechanism. The transverse movement mechanism can drive the sampling port of the large reagent sampling mechanism, the liquid inlet of the cleaning mechanism and the waste suction port of the waste suction mechanism to move; the coverslip conversion mechanism includes a two-axis movement mechanism, a coverslip support and a rotation conversion mechanism. The coverslip support is respectively provided with a large reagent coverslip installation position and a micro reagent coverslip installation position. The coverslip support is movably installed on the two-axis movement mechanism. The two-axis movement mechanism can drive the coverslip support to move along a straight line, and the rotation conversion mechanism drives the coverslip support to rotate. The micro reagent sampling mechanism includes a three-axis movement mechanism and a sampling needle installed thereon. The three-axis movement mechanism drives the sampling needle to move. This device has the advantages of high throughput processing capacity, extremely high reagent utilization rate and less cross contamination, etc.