42 results about "Carbo-mer" patented technology

The invention discloses a gel dressing for treating haemorrhoids and a preparation method of the gel dressing. The gel dressing is prepared from the following raw materials in parts by weight: modified chitosan, multifunctional lipidosome, fructo-oligosaccharide, hyaluronic acid, carbomer, glycerol and recombinant human epidermal growth factors. Chitosan has good film-forming property and antibacterial activity, when haemorrhoids are cracked and bleeding due to long-term constipation, a wound surface is in a high-pH and high-ROS environment, the modified chitosan forms a compact protective film on the ulcerated wound surface, the multifunctional lipidosome with contracted film holes and larger particle size is blocked outside, heparin molecules are grafted on the modified chitosan, and the heparin molecules are grafted on the surface of the wound surface. Recombinant human epidermal growth factors are allowed to pass through, and wound healing is accelerated. When the ulceration part is gradually healed, the pH and ROS level return to normal, the protective film of the modified chitosan is expanded, and the multifunctional liposome is diffused and degraded through the protective film to release the pepper extract, the borneol and the menthol. Fructo-oligosaccharide is added to maintain normal flora balance in the anorectum area.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for detecting the content of carbomer in eye drops. The method comprises the following steps: by adopting a two-time washing and centrifugal separation mode, controlling the washing and centrifugal times, centrifugal conditions and washing volume, separating carbomer and brinzolamide from other auxiliary materials in the brinzolamide eye drops, obtaining the weights of carbomer and brinzolamide by adopting a drying and weighing mode, subtracting the weight of brinzolamide, and calculating the content of the auxiliary materials in the brinzolamide eye drops. And calculating to obtain the carbomer content in the sample. The method is suitable for detecting the carbomer content in the carbomer-containing brinzolamide eye drops, and is simple and convenient to operate, efficient, accurate and low in cost.

The invention discloses engineered small extracellular vesicle hydrogel as well as a preparation method and application thereof. The engineered small extracellular vesicle hydrogel comprises a hydrogel matrix, and GDNF-sEVs and a polyphenol compound which are loaded in the hydrogel matrix, wherein the hydrogel matrix comprises a polyacrylamide polymer, xanthan gum and carbomer, the polyacrylamide polymer comprises the following structural unit: [-CH2CH (-CONH-RX-CONH2)-], RX is C1-4 alkylene, and the polyacrylamide polymer comprises the following structural unit:-CH2CH (-CONH-RX-CONH2)-[-CH2CH (-CONH-RX-CONH2)-]. The GDNF-sEVs are small extracellular vesicles loaded with glial cell-derived neurotrophic factors (GDNF-sEVs). According to the engineered small extracellular vesicle hydrogel, through the synergistic effect of the small extracellular vesicles, the glial cell-derived neurotrophic factors and the hydrogel matrix, the injury microenvironment after spinal cord injury can be regulated and controlled, and repair of spinal cord injury is promoted.

The invention provides a permeation promoting composition containing PDRN and glabridin and application of the permeation promoting composition in functional skin care products. The composition comprises the following components in percentage by mass: 0.01%-5% of glabridin, 0.1%-10% of glycyrrhizic acid ester stearate, 0.01%-2% of DNA sodium, 0.1%-10% of poloxamer, 0.05%-8% of carbomer, 0.5%-5% of sodium hyaluronate and the balance of one or more of water or solvents such as butanediol, glycerol, 1.3-propylene glycol and the like. In the composition, poloxamer is self-assembled in a system to form micelles, glabridin is wrapped in an inner core, and a PEO chain segment on an outer layer is combined with hyaluronic acid through a hydrogen bond to form a molecular-level wrapping structure, so that the problem of instability of glabridin is effectively solved, meanwhile, the problem of agglomeration of glabridin can be effectively avoided, and the whitening effect of glabridin is effectively promoted. Meanwhile, the glabridin, the glycyrrhizic acid ester stearate, the DNA sodium, the poloxamer, the carbomer and the hyaluronic acid are synergistically matched, so that the composition has good whitening, anti-wrinkle and penetration promoting effects.

The invention provides carbomer as well as a preparation method and application thereof. The preparation method comprises the following steps: adding a first solvent and a dispersing agent into a reaction container to obtain a first mixed solution; respectively preparing an unsaturated carboxylic acid monomer solution, a crosslinking monomer solution, a hydrophobic monomer solution and a second mixed solution; respectively and independently dropwise adding the unsaturated carboxylic acid monomer solution, the cross-linking monomer solution, the hydrophobic monomer solution and the second mixed solution into the first mixed solution within x h at the temperature of 50-70 DEG C to obtain a third mixed solution, and after dropwise adding is finished, keeping the temperature for 2-3 h; wherein x is more than or equal to 3 and less than or equal to 6, the dropwise adding percentage content of the cross-linking monomer solution per x / 4h is gradually reduced along with time, and the dropwise adding percentage content of the hydrophobic monomer solution per x / 4h is gradually increased along with time; after heat preservation is finished, adding the initiator into the third mixed solution again, and separating to obtain carbomer. Therefore, the prepared carbomer has good thickening performance and salt resistance.

The invention discloses an adapalene gel preparation method, which comprises: 1) preparing a carbomer phase: mixing a first solution and a second solution to obtain a mixed solution, and adding carbomer into the mixed solution, the first solution being obtained by mixing edetate disodium and water, the second solution being obtained by mixing edetate disodium and water, and the first solution being obtained by mixing edetate disodium and water; the second solution is obtained by mixing phenoxyethanol, methylparaben and propylene glycol; 2) preparation of adapalene phase: adding water into poloxamer to obtain a solution, and then adding adapalene into the solution; and 3) total mixing: mixing the adapalene phase and the carbomer phase while stirring to obtain a gel precursor, and then degassing, filling and sealing the gel precursor.

The invention discloses a tissue regeneration promoting jade red gel and a quality detection method thereof.The tissue regeneration promoting jade red gel is characterized in that on the basis of a single-factor test, the dosage of carbomer 940, medicine and triethanolamine is used as influence factors, and the optimal proportion of all components of the gel is determined through an orthogonal test method: the dosage of carbomer 940 is 1%, the medicine loading capacity is 11%, and the dosage of triethanolamine is 1%; the results of accelerated stability and long-term stability tests show that the preparation has good stability in the investigation period. According to the method, the optimal thin-layer chromatography development condition is screened out, the radix angelicae sinensis, the radix arnebiae seu lithospermi and the sangusis draconis in the tissue regeneration promoting jade red gel are subjected to qualitative identification research, and chromatographic conditions such as the optimal flowability composition and a gradient elution mode are screened out through a large number of experiments; according to the present invention, with the high performance liquid chromatography method, the contents of the effective components such as ferulic acid, liquiritin, imperatorin, ligustilide, isoimperatorin and the like can be simultaneously determined, and the methodological detection results show that the high performance liquid chromatography method has characteristics of high precision, high accuracy, good repeatability and good stability.

The invention relates to the technical field of gel preparations, in particular to selenium disulfide gel and a preparation method thereof. The raw materials for forming the selenium disulfide gel are selected from selenium disulfide, a metal ion complexing agent, carbomer, a pH regulator, lauryl sulfate salt and a solvent. The selenium disulfide gel has excellent stability, and particularly, the selenium disulfide gel is not prone to discoloring and layering after being stored at high temperature for a long time.

The invention relates to the technical field of medicines, in particular to a multifunctional sustained-release medicine framework material as well as a preparation method and application thereof. The material is hydrophilic and hydrophobic double-segment composite modified carbomer premixed powder and is prepared from a carbomer homopolymer type A 971P NF, a carbomer homopolymer type B 974P NF, poloxamer 407 and a double-molecular-weight polyethylene glycol dextrin compound according to the weight ratio of (20 to 28) to (10 to 14) to (10 to 14) to (9 to 15). The preparation method comprises the following steps: carrying out spray drying to prepare a compound, carrying out acidic dispersion on carbomer, adding a poloxamer solution in batches, adjusting the pH value to 5.2-5.8, and drying to obtain the premix powder. The material is used for a dihydroergoline mesylate oral sustained-release solid preparation, through the design of a pre-neutralization shell layer and a middle skeleton layer, the gel strength and alteration behavior are synergistically regulated and controlled, early burst release is effectively inhibited, later stable release is ensured, 24-hour near-zero-level drug release is realized, and the plasma concentration stability and the curative effect consistency are improved.

The invention discloses antibacterial hydrogel as well as a preparation method and application thereof. The antibacterial hydrogel comprises a carbomer hydrogel matrix and gold nanoclusters dispersed in the carbomer hydrogel matrix, wherein the gold nanocluster is crosslinked with the carbomer through a hydrogen bond. The antibacterial hydrogel is formed by crosslinking gold nanoclusters (GNCs) and carbomer (CBM) through hydrogen bonds, and the GNCs serving as an antibacterial active component can achieve an efficient antibacterial effect by destroying a bacterial membrane structure, inducing an oxidative stress reaction, interfering bacterial metabolism and the like; cBM is used as a hydrogel matrix, so that excellent adhesiveness and barrier effect are provided, the structure of GNCs can be stabilized through hydrogen-bond interaction, and the antibacterial activity of the GNCs is improved. In addition, GNCs also has an immunoregulation characteristic and can induce M2 polarization of macrophages, so that inflammatory response is reduced and wound repair is promoted.

The invention discloses a preparation method of panda-derived exosome gel. The preparation method comprises the following steps: step 1, culturing panda umbilical cord-derived mesenchymal stem cells by using a culture medium; 2, culturing in an air-permeable culture bottle, and then collecting cell supernate; 3, centrifuging for five times, and continuing to resuspend with the PBS buffer solution to obtain an exosome solution; and 4, adding carbomer into a proper amount of distilled water, continuously stirring, sterilizing after the carbomer is swelled into a semitransparent solution, then adding the exosome solution and triethanolamine, uniformly stirring, gradually adding the ethylparaben solution, triethanolamine and glycerol, then adding distilled water, uniformly stirring, and storing to obtain the exosome gel. The invention further provides panda-derived exosome gel and an effect of the panda-derived exosome gel in promoting wound healing of pandas. The invention provides a panda-derived new medicine which can be used for promoting wound healing of pandas and has a relatively good anti-inflammatory effect.

The present application provides a method for testing the swelling degree of carbomer gel. By testing the swelling degree of carbomer gel in the same electrolyte and solvents with different concentrations, the first swelling degree corresponding to each selected sol is obtained; based on all the first swelling degrees, the contribution degree of the hydrophilicity of carbomer gel to the change in swelling degree is determined; the swelling degree of carbomer gel is tested in different electrolytes and solvents with different concentrations to obtain the second swelling degree corresponding to each selected sol; based on all the second swelling degrees, the amount of solvent wrapped by the molecular chains in carbomer gel under unit ionic strength is determined; according to the contribution degree and the wrapped amount, the swelling responsiveness of the swelling degree of carbomer gel to the change in ionic strength in the solvent is determined, and the swelling degree test result is generated based on the swelling responsiveness. By adopting the solution of the present application, a transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent can be established, thereby improving the versatility of the swelling degree test result of carbomer gel.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a riptacaine cream and a preparation process thereof. A part of water, polyoxyethylene hydrogenated castor oil and a part of carbomer are preferentially mixed to form a water phase, so that the operation temperature in the cream production process can be reduced, hydrogen bonds can be further formed between polyoxyethylene hydrogenated castor oil and carbomer molecules, and meanwhile, carbomer forms a loose three-dimensional structure. When an oil phase and a water phase are mixed, homogenized and emulsified, a hydrogen bond formed between polyoxyethylene hydrogenated castor oil and carbomer molecules can buffer pulling of a homogenized shear force on a stretched carbomer molecular chain to prevent the carbomer molecular chain from being broken. Secondly, after emulsification, a composite interfacial film of a surfactant and macromolecules can be formed on the surface of an oil phase, so that damage to emulsion droplets during collision of the oil droplets can be effectively resisted, and coalescence and flocculation are reduced. The ripropylene dicaine cream prepared by the invention is milk white paste with fine texture, the particle size range is 1-2 microns, and the character, the particle size and the viscosity are basically unchanged after a low-temperature cycle test.

The present application relates to the technical field of gynecological bacteriostatic gel, and particularly relates to a ulipristal bacteriostatic gel and a preparation method thereof; the ulipristal bacteriostatic gel comprises the following components in parts by weight: chlorhexidine acetate 1-3 parts, meihua grass extract 4-8 parts, carbomer 0.8-1.2 parts, triethanolamine 0.4-0.6 parts, penetration enhancer 0.5-1.5 parts, modified nano-silver 0.04-0.07 parts, glycerol 5-8 parts, hydrogenated polyisobutylene 0.03-0.07 parts, disodium edetate 0.1-0.3 parts and purified water in a remainder amount; the chlorhexidine acetate and the meihua grass ethanol extract are compounded at a ratio of 1:(2.5-4), the flavones and polyphenols in the meihua grass can destroy the cell membrane permeability of microorganisms, promote the chlorhexidine acetate to enter the inside of the microorganism, and significantly reduce the minimum bacteriostatic concentration.

The application provides a carbomer and a preparation method and application thereof. The preparation method comprises the following steps: adding a first solvent and a dispersing agent into a reaction container to obtain a first mixed solution; separately preparing an unsaturated carboxylic acid monomer solution, a crosslinking monomer solution, a hydrophobic monomer solution and a second mixed solution; adding the unsaturated carboxylic acid monomer solution, the crosslinking monomer solution, the hydrophobic monomer solution and the second mixed solution into the first mixed solution at 50-70 DEG C within x hours to obtain a third mixed solution, and keeping the third mixed solution for 2-3 hours after the addition is completed; wherein 3<=x<=6, the percentage content of the crosslinking monomer solution added every x / 4 hours decreases with time, and the percentage content of the hydrophobic monomer solution added every x / 4 hours increases with time; and adding an initiator into the third mixed solution again after the keeping is completed, and separating to obtain the carbomer. The prepared carbomer has good thickening performance and salt resistance.

The invention belongs to the technical field of biology, and discloses application of a composition of neoagaro-oligosaccharide and astaxanthin in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the invention comprises neoagaro-oligosaccharide, astaxanthin, carbomer and alginate in a mass ratio of (1-10): (1-10): (0.01-0.5): (0.1-1), and can realize efficient enrichment of neoagaro-oligosaccharide and astaxanthin in an articular cavity through a substance diffusion path of skin penetration, deep tissue diffusion, joint capsule permeation and articular cavity enrichment, so that the content of neoagaro-oligosaccharide and astaxanthin in the articular cavity is improved, and the content of astaxanthin in the articular cavity is reduced. The new agar oligosaccharide and the astaxanthin have an excellent synergistic effect, so that the acute inflammation symptom of gouty osteoarthritis can be efficiently relieved, the progress of the disease course is blocked, the pathological change of joint tissue is repaired, and the new agar oligosaccharide and the astaxanthin have an excellent application prospect in preparation of the transdermal medicine for treating osteoarthritis.

The invention discloses a female private care gel with multiple effects and a preparation method thereof. The gel is prepared from the following components: carbomer 980, palmitoyl 3 peptide, phenethyl caffeate, glycerol, pentanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, panthenol, glycerol glucoside, crithmum maritimum callus fermentation filtrate, lysozyme, an ecological nutrient solution and the balance of water. According to the female private care gel disclosed by the invention, through a scientific formula and a reasonable preparation process, the synergistic effect of all the components is fully exerted, the use limitation of palmitoyl 3 peptide in vaginal gel is effectively solved, and the gel can better adapt to the vaginal environment, promote the production of collagen and realize the effects of tightening and moisturizing. Meanwhile, the product has multiple effects of repairing in vitro, moisturizing, relieving, resisting inflammation, regulating flora balance and the like, comprehensively cares female private health, and has a wide market application prospect.

The invention relates to the technical field of pharmaceutical analysis, in particular to an ICP-OES (Inductively Coupled Plasma-Optical Emission Spectrometry) detection method for the content of carbomer in cyclosporine eye drops. The method comprises the following steps: fully dissociating carboxylic acid groups of carbomer under alkaline conditions, carrying out metering reaction on the carboxylic acid groups and added calcium ions, detecting the content of residual calcium elements in a solution after the reaction through ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometry), and carrying out back calculation by combining with a metering relationship between the calcium ions and carbomer, so as to obtain the content of carbomer in the cyclosporine eye drops. Compared with an existing titration method, the method is easy and convenient to operate, high in detection efficiency and good in repeatability and accuracy, can effectively adapt to complex matrix systems such as cyclosporine eye drops and the like, and has good industrial application value.

The application relates to the technical field of functional materials, and discloses a preparation method of a silver-based metal-organic framework hydrogel composite material and application of the silver-based metal-organic framework hydrogel composite material in antibiosis, which comprises the following steps: respectively dissolving silver nitrate and 3-methyl-5-trifluoromethyl-1H-1,2,4-triazole in 5 milliliters of 5% ammonia water according to a molar ratio of 1:1; synthesizing by adopting an interfacial synthesis method, with 5 milliliters of 5% ammonia water as an intermediate layer; avoiding light and standing; adding the silver-based metal-organic framework material into distilled water, and ultrasonic dispersing for a second preset time length; mixing with carbomer with a concentration of 9.8 grams per liter, adding triethanolamine with a concentration of 5 grams per liter when the solution becomes clear; and stirring at a second mixing rate until a uniform gel is formed. The silver-based metal-organic framework hydrogel composite material prepared by the application has excellent antibacterial activity, biocompatibility, appropriate mechanical properties and adhesion, stable rheological properties, and is stronger than a commercial AgNPs-gel.

The present application belongs to the field of polymer detection, and particularly relates to a method for determining the content of carbomer in a preparation by high performance liquid chromatography-evaporative light scattering, comprising the steps of chromatographic conditions, drawing a standard curve of the logarithm of the carbomer concentration versus the logarithm of the peak area, preparing a blank sample solution, preparing and detecting a test sample solution, and the like. The present method utilizes the linear relationship between the logarithm of the concentration of carbomer in an evaporative light scattering detector and the logarithm of the response value, and through a certain sample pretreatment method, the carbomer is quantitatively dissolved and uniformly dispersed in a solvent, and then enters the HPLC-ELSD chromatographic system, so as to achieve the purpose of quantitative detection. The detection method realizes the quantitative detection of the commonly used auxiliary material carbomer in an external semi-solid preparation, thereby effectively guiding the self-made preparation to be consistent with the prescription of the reference preparation.

The invention relates to the technical field of biological medicine, and particularly discloses a preparation method of a collagen and anti-propionibacterium acnes gamma protein combined preparation, and the preparation method of the collagen and anti-propionibacterium acnes gamma protein combined preparation comprises the following steps: preparing anti-propionibacterium acnes gamma protein; adding water into the anti-propionibacterium acnes gamma protein and the recombinant III-type collagen, stirring and mixing, adding glycerol and a neutralizing agent, and mixing to obtain a uniform solution; the preparation method comprises the following steps: dispersing carbomer with water, adding a preservative and a humectant, mixing, finally adding the uniform solution, and mixing to obtain the required collagen and anti-propionibacterium acnes gamma protein combined preparation. The combined preparation prepared by the method can be used for effectively treating acnes, is remarkable in curative effect, does not generate drug resistance, is short in treatment cycle, can quickly eliminate skin damage, promote cell growth and adhesion and repair skin barriers, and does not generate new rash after healing.

The invention relates to the field of medical dressings, in particular to a transdermal drug delivery dressing and a preparation method thereof. The dressing comprises carbomer, carboxymethyl chitosan, sodium polyacrylate, sodium tripolyphosphate, triethanolamine and water, and the content of each component is limited. According to the invention, a'carbomer-triethanolamine 'and'carboxymethyl chitosan-sodium tripolyphosphate' double-gel system is ingeniously constructed, and the moisturizing and enhancing effects of sodium polyacrylate are supplemented; the transdermal delivery hydrogel dressing which integrates excellent adhesion, good mechanical strength, lasting moisturizing capacity, excellent biocompatibility and wide drug adaptability is successfully developed. According to the dressing, the common key problems of poor gel stability, skin irritation risk, limited drug loading, poor process reproducibility and the like in the prior art are effectively solved, and a solution with a great application prospect is provided for developing a new generation of efficient, safe and comfortable transdermal drug delivery products.

According to the graft modified carbomer and the preparation method and application thereof, based on the chemical reactivity of carboxyl of carbomer and amino / catechol group (and oxidation product quinonyl) of dopamine, through amidation, Michael addition and other covalent bond formation reactions, grafting of micromolecular functional groups to a high-molecular main chain is achieved, the hydrophilicity of carbomer can be enhanced, and the hydrophilicity of the carbomer can be enhanced; the wettability of water to the carbomer particles is improved; agglomeration is avoided, so that water phase permeation and molecular chain dispersion are accelerated, and the dissolution time is shortened; the net-shaped structure is more compact, and the amount of wrapped water is increased, so that the viscosity of the system is obviously improved; the dopamine is grafted to the carbomer, so that the modified carbomer has excellent biological activity and is more suitable for the field of biomedicine, the defects of long dissolution time, insufficient viscosity stability and the like of the carbomer in the prior art are effectively overcome, and the application prospect is wide.

The invention relates to a medical dressing containing high-concentration lactic acid and a preparation method thereof, and belongs to the technical field of medical dressings. According to the invention, carbomer is subjected to chemical crosslinking and ion coordination combination, so that the problem of gel collapse caused by contact of medical dressing with wound exudate and gel is solved, and then octadecyl methacrylate is grafted with carbomer to form a hydrophobic core and form a hydrophilic shell with bi-crosslinked carbomer; long-chain alkyl of octadecyl methacrylate forms a compact hydrophobic region, and a hydrophilic shell swells when being in contact with wound exudate, so that the problem of gel collapse is further solved, release of lactic acid is effectively controlled, and wound healing is promoted.

The invention relates to the technical field of nursing hygiene products, and particularly discloses a female private part antibacterial nursing gel and a preparation method thereof.The female private part antibacterial nursing gel is prepared from, by mass, 1%-3% of silver ion albumen glue, 10%-16% of carbomer, 10%-20% of a composite humectant, 0.04%-0.08% of a complexing agent and the balance purified water, and the mass percent of the silver ion albumen glue, the carbomer, the composite humectant, the complexing agent and the balance purified water are 100%. The gel provided by the invention is good in retention property, the antibacterial components without drug resistance risk are adopted to effectively kill various pathogenic bacteria and quickly relieve gynecological inflammation, and the antibacterial components have selectivity, do not indiscriminately kill symbiotic bacteria, and can maintain micro-ecological balance of private parts and keep the private parts healthy.

The present invention relates to a composition with facial repair efficacy. By weight percentage, the composition contains 0.01-5% of cell protein extract, 3-10% of propylene glycol, 0.1-5% of xanthan gum, 0.01-0.1% of hyaluronic acid, 0.1-5% of symex, 0.01-1% of disodium EDTA, 0.5-10% of erythritol, 0.5-10% of β-glucan, 0.1-5% of carbomer, 0.1-5% of triethanolamine, 0.01-1% of dipotassium glycyrrhizinate, 0.1-5% of Piper methysticum root extract, 0.1-5% of 1,2-hexanediol, 0.01-1% of fullerene, 0.0001-0.1% of superoxide dismutase (SOD), and the balance is water. The composition of the present invention can effectively promote cell repair and regeneration, delay skin aging, and achieve the effects of whitening, anti-aging, calming and soothing.

The invention belongs to the technical field of dressings, and particularly relates to a gel dressing containing recombinant collagen as well as a preparation method and application of the gel dressing. The gel dressing containing the recombinant collagen is prepared from the following raw materials in percentage by weight: 0.1 to 1 percent of the recombinant collagen, 0.5 to 1 percent of sodium hyaluronate, 0.08 to 0.15 percent of radices stellariae dichotomae cyclopeptide, 0.5 to 1 percent of carbomer, 0.03 to 0.06 percent of cryptomeria fortunei bud extract, 15 to 20 percent of poloxamer, 0.1 to 0.5 percent of xanthan gum, 3 to 8 percent of glycerol, 0.04 to 0.08 percent of edetate disodium, 0.1 to 0.3 percent of triethanolamine, 0.08 to 0.12 percent of preservative and the balance of deionized water. The gel dressing has excellent biocompatibility, good hemostasis, cell growth promotion and tissue repair performance, and can be used for repairing vaginal mucous membrane chap and hemostasis of diffuse superficial bleeding, and improving the symptoms of elasticity reduction and the like caused by vaginal atrophy.

The invention provides a composition containing compound polymyxin B and a preparation method of the composition. Carbomer is adopted as a gel type matrix and is subjected to high-pressure homogeneous dispersion, and the addition amount of the Carbomer and high-pressure homogeneous dispersion parameter conditions are controlled, so that lidocaine hydrochloride is uniformly dispersed in the matrix; the composition has good content uniformity, rheological property and in-vitro release effect, can form a layer of transparent or semitransparent gel on the skin after being used by a patient, has good moisture retention, air permeability and sterilization effect, can delay the residence time of the medicine on the skin surface and increase the curative effect of the medicine, and is few in component variety, low in cost and suitable for popularization and application. The method is suitable for large-scale industrial production.

The application discloses an anti-hair-loss original solution containing transdermal recombinant collagen and a preparation method thereof. The anti-hair-loss original solution comprises the following components in percentage by mass: 0.5-2% of recombinant collagen glycerol, 2-10% of glycerol, 0.5-5% of 1,2-hexanediol, 0.5-6% of p-hydroxyacetophenone, 0.1-0.7% of sodium hyaluronate, 0.5-5% of 1,2-pentanediol, 0.05-2% of aminomethylpropanol, 0.05-2% of plant soothing agent SGS, 0.1-2% of carbomer U21, and the rest is water. The application uses the glycerol encapsulation technology to encapsulate the high-activity recombinant collagen in the glycerol vesicle, improves the transdermal property of the recombinant collagen, and forms the anti-hair-loss original solution by compounding the transdermal recombinant collagen as the active component with other raw materials, which has the effects of moisturizing and water-locking the skin and preventing hair loss.

The invention provides the preparation method of the radiation-resistant carbomer, the preparation method of the radiation-resistant carbomer is simple, rapid and efficient, the carbomer structure is effectively controlled by regulating and controlling the ratio of a copolymerized hydrophobic monomer and the content of allyl polyol, vinyl polysiloxane, a cross-linking agent and monoallyl ether are copolymerized on a carbomer chain segment, and the radiation-resistant carbomer is prepared. Meanwhile, the ratio of carboxylate to carboxylate radicals is adjusted, hydrophilicity is improved, wetting of carbomer is accelerated, interaction of hydroxyl groups on a carbomer structure after neutralization is enhanced, the combination effect with water is enhanced, and meanwhile, by means of the low polarity and caging effect of polysiloxane chain segments, the high radiation resistance and ion resistance are achieved. The obtained radiation-resistant carbomer has the characteristics of high viscosity, high wetting speed, good ion resistance, high transparency, good radiation resistance and the like.