29 results about "Carbo-mer" patented technology

The invention provides carbomer as well as a preparation method and application thereof. The preparation method comprises the following steps: adding a first solvent and a dispersing agent into a reaction container to obtain a first mixed solution; respectively preparing an unsaturated carboxylic acid monomer solution, a crosslinking monomer solution, a hydrophobic monomer solution and a second mixed solution; respectively and independently dropwise adding the unsaturated carboxylic acid monomer solution, the cross-linking monomer solution, the hydrophobic monomer solution and the second mixed solution into the first mixed solution within x h at the temperature of 50-70 DEG C to obtain a third mixed solution, and after dropwise adding is finished, keeping the temperature for 2-3 h; wherein x is more than or equal to 3 and less than or equal to 6, the dropwise adding percentage content of the cross-linking monomer solution per x / 4h is gradually reduced along with time, and the dropwise adding percentage content of the hydrophobic monomer solution per x / 4h is gradually increased along with time; after heat preservation is finished, adding the initiator into the third mixed solution again, and separating to obtain carbomer. Therefore, the prepared carbomer has good thickening performance and salt resistance.

The invention discloses an adapalene gel preparation method, which comprises: 1) preparing a carbomer phase: mixing a first solution and a second solution to obtain a mixed solution, and adding carbomer into the mixed solution, the first solution being obtained by mixing edetate disodium and water, the second solution being obtained by mixing edetate disodium and water, and the first solution being obtained by mixing edetate disodium and water; the second solution is obtained by mixing phenoxyethanol, methylparaben and propylene glycol; 2) preparation of adapalene phase: adding water into poloxamer to obtain a solution, and then adding adapalene into the solution; and 3) total mixing: mixing the adapalene phase and the carbomer phase while stirring to obtain a gel precursor, and then degassing, filling and sealing the gel precursor.

The invention discloses a tissue regeneration promoting jade red gel and a quality detection method thereof.The tissue regeneration promoting jade red gel is characterized in that on the basis of a single-factor test, the dosage of carbomer 940, medicine and triethanolamine is used as influence factors, and the optimal proportion of all components of the gel is determined through an orthogonal test method: the dosage of carbomer 940 is 1%, the medicine loading capacity is 11%, and the dosage of triethanolamine is 1%; the results of accelerated stability and long-term stability tests show that the preparation has good stability in the investigation period. According to the method, the optimal thin-layer chromatography development condition is screened out, the radix angelicae sinensis, the radix arnebiae seu lithospermi and the sangusis draconis in the tissue regeneration promoting jade red gel are subjected to qualitative identification research, and chromatographic conditions such as the optimal flowability composition and a gradient elution mode are screened out through a large number of experiments; according to the present invention, with the high performance liquid chromatography method, the contents of the effective components such as ferulic acid, liquiritin, imperatorin, ligustilide, isoimperatorin and the like can be simultaneously determined, and the methodological detection results show that the high performance liquid chromatography method has characteristics of high precision, high accuracy, good repeatability and good stability.

The invention relates to the technical field of gel preparations, in particular to selenium disulfide gel and a preparation method thereof. The raw materials for forming the selenium disulfide gel are selected from selenium disulfide, a metal ion complexing agent, carbomer, a pH regulator, lauryl sulfate salt and a solvent. The selenium disulfide gel has excellent stability, and particularly, the selenium disulfide gel is not prone to discoloring and layering after being stored at high temperature for a long time.

The invention relates to the technical field of medicines, in particular to a multifunctional sustained-release medicine framework material as well as a preparation method and application thereof. The material is hydrophilic and hydrophobic double-segment composite modified carbomer premixed powder and is prepared from a carbomer homopolymer type A 971P NF, a carbomer homopolymer type B 974P NF, poloxamer 407 and a double-molecular-weight polyethylene glycol dextrin compound according to the weight ratio of (20 to 28) to (10 to 14) to (10 to 14) to (9 to 15). The preparation method comprises the following steps: carrying out spray drying to prepare a compound, carrying out acidic dispersion on carbomer, adding a poloxamer solution in batches, adjusting the pH value to 5.2-5.8, and drying to obtain the premix powder. The material is used for a dihydroergoline mesylate oral sustained-release solid preparation, through the design of a pre-neutralization shell layer and a middle skeleton layer, the gel strength and alteration behavior are synergistically regulated and controlled, early burst release is effectively inhibited, later stable release is ensured, 24-hour near-zero-level drug release is realized, and the plasma concentration stability and the curative effect consistency are improved.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a riptacaine cream and a preparation process thereof. A part of water, polyoxyethylene hydrogenated castor oil and a part of carbomer are preferentially mixed to form a water phase, so that the operation temperature in the cream production process can be reduced, hydrogen bonds can be further formed between polyoxyethylene hydrogenated castor oil and carbomer molecules, and meanwhile, carbomer forms a loose three-dimensional structure. When an oil phase and a water phase are mixed, homogenized and emulsified, a hydrogen bond formed between polyoxyethylene hydrogenated castor oil and carbomer molecules can buffer pulling of a homogenized shear force on a stretched carbomer molecular chain to prevent the carbomer molecular chain from being broken. Secondly, after emulsification, a composite interfacial film of a surfactant and macromolecules can be formed on the surface of an oil phase, so that damage to emulsion droplets during collision of the oil droplets can be effectively resisted, and coalescence and flocculation are reduced. The ripropylene dicaine cream prepared by the invention is milk white paste with fine texture, the particle size range is 1-2 microns, and the character, the particle size and the viscosity are basically unchanged after a low-temperature cycle test.

The present application relates to the technical field of gynecological bacteriostatic gel, and particularly relates to a ulipristal bacteriostatic gel and a preparation method thereof; the ulipristal bacteriostatic gel comprises the following components in parts by weight: chlorhexidine acetate 1-3 parts, meihua grass extract 4-8 parts, carbomer 0.8-1.2 parts, triethanolamine 0.4-0.6 parts, penetration enhancer 0.5-1.5 parts, modified nano-silver 0.04-0.07 parts, glycerol 5-8 parts, hydrogenated polyisobutylene 0.03-0.07 parts, disodium edetate 0.1-0.3 parts and purified water in a remainder amount; the chlorhexidine acetate and the meihua grass ethanol extract are compounded at a ratio of 1:(2.5-4), the flavones and polyphenols in the meihua grass can destroy the cell membrane permeability of microorganisms, promote the chlorhexidine acetate to enter the inside of the microorganism, and significantly reduce the minimum bacteriostatic concentration.

The application provides a carbomer and a preparation method and application thereof. The preparation method comprises the following steps: adding a first solvent and a dispersing agent into a reaction container to obtain a first mixed solution; separately preparing an unsaturated carboxylic acid monomer solution, a crosslinking monomer solution, a hydrophobic monomer solution and a second mixed solution; adding the unsaturated carboxylic acid monomer solution, the crosslinking monomer solution, the hydrophobic monomer solution and the second mixed solution into the first mixed solution at 50-70 DEG C within x hours to obtain a third mixed solution, and keeping the third mixed solution for 2-3 hours after the addition is completed; wherein 3<=x<=6, the percentage content of the crosslinking monomer solution added every x / 4 hours decreases with time, and the percentage content of the hydrophobic monomer solution added every x / 4 hours increases with time; and adding an initiator into the third mixed solution again after the keeping is completed, and separating to obtain the carbomer. The prepared carbomer has good thickening performance and salt resistance.

The invention belongs to the technical field of biology, and discloses application of a composition of neoagaro-oligosaccharide and astaxanthin in preparation of a transdermal drug for treating osteoarthritis and a composite gel preparation. The composition provided by the invention comprises neoagaro-oligosaccharide, astaxanthin, carbomer and alginate in a mass ratio of (1-10): (1-10): (0.01-0.5): (0.1-1), and can realize efficient enrichment of neoagaro-oligosaccharide and astaxanthin in an articular cavity through a substance diffusion path of skin penetration, deep tissue diffusion, joint capsule permeation and articular cavity enrichment, so that the content of neoagaro-oligosaccharide and astaxanthin in the articular cavity is improved, and the content of astaxanthin in the articular cavity is reduced. The new agar oligosaccharide and the astaxanthin have an excellent synergistic effect, so that the acute inflammation symptom of gouty osteoarthritis can be efficiently relieved, the progress of the disease course is blocked, the pathological change of joint tissue is repaired, and the new agar oligosaccharide and the astaxanthin have an excellent application prospect in preparation of the transdermal medicine for treating osteoarthritis.

The invention discloses a female private care gel with multiple effects and a preparation method thereof. The gel is prepared from the following components: carbomer 980, palmitoyl 3 peptide, phenethyl caffeate, glycerol, pentanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, panthenol, glycerol glucoside, crithmum maritimum callus fermentation filtrate, lysozyme, an ecological nutrient solution and the balance of water. According to the female private care gel disclosed by the invention, through a scientific formula and a reasonable preparation process, the synergistic effect of all the components is fully exerted, the use limitation of palmitoyl 3 peptide in vaginal gel is effectively solved, and the gel can better adapt to the vaginal environment, promote the production of collagen and realize the effects of tightening and moisturizing. Meanwhile, the product has multiple effects of repairing in vitro, moisturizing, relieving, resisting inflammation, regulating flora balance and the like, comprehensively cares female private health, and has a wide market application prospect.

The invention relates to the technical field of pharmaceutical analysis, in particular to an ICP-OES (Inductively Coupled Plasma-Optical Emission Spectrometry) detection method for the content of carbomer in cyclosporine eye drops. The method comprises the following steps: fully dissociating carboxylic acid groups of carbomer under alkaline conditions, carrying out metering reaction on the carboxylic acid groups and added calcium ions, detecting the content of residual calcium elements in a solution after the reaction through ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometry), and carrying out back calculation by combining with a metering relationship between the calcium ions and carbomer, so as to obtain the content of carbomer in the cyclosporine eye drops. Compared with an existing titration method, the method is easy and convenient to operate, high in detection efficiency and good in repeatability and accuracy, can effectively adapt to complex matrix systems such as cyclosporine eye drops and the like, and has good industrial application value.

The application relates to the technical field of functional materials, and discloses a preparation method of a silver-based metal-organic framework hydrogel composite material and application of the silver-based metal-organic framework hydrogel composite material in antibiosis, which comprises the following steps: respectively dissolving silver nitrate and 3-methyl-5-trifluoromethyl-1H-1,2,4-triazole in 5 milliliters of 5% ammonia water according to a molar ratio of 1:1; synthesizing by adopting an interfacial synthesis method, with 5 milliliters of 5% ammonia water as an intermediate layer; avoiding light and standing; adding the silver-based metal-organic framework material into distilled water, and ultrasonic dispersing for a second preset time length; mixing with carbomer with a concentration of 9.8 grams per liter, adding triethanolamine with a concentration of 5 grams per liter when the solution becomes clear; and stirring at a second mixing rate until a uniform gel is formed. The silver-based metal-organic framework hydrogel composite material prepared by the application has excellent antibacterial activity, biocompatibility, appropriate mechanical properties and adhesion, stable rheological properties, and is stronger than a commercial AgNPs-gel.

The present application belongs to the field of polymer detection, and particularly relates to a method for determining the content of carbomer in a preparation by high performance liquid chromatography-evaporative light scattering, comprising the steps of chromatographic conditions, drawing a standard curve of the logarithm of the carbomer concentration versus the logarithm of the peak area, preparing a blank sample solution, preparing and detecting a test sample solution, and the like. The present method utilizes the linear relationship between the logarithm of the concentration of carbomer in an evaporative light scattering detector and the logarithm of the response value, and through a certain sample pretreatment method, the carbomer is quantitatively dissolved and uniformly dispersed in a solvent, and then enters the HPLC-ELSD chromatographic system, so as to achieve the purpose of quantitative detection. The detection method realizes the quantitative detection of the commonly used auxiliary material carbomer in an external semi-solid preparation, thereby effectively guiding the self-made preparation to be consistent with the prescription of the reference preparation.

The invention relates to the technical field of biological medicine, and particularly discloses a preparation method of a collagen and anti-propionibacterium acnes gamma protein combined preparation, and the preparation method of the collagen and anti-propionibacterium acnes gamma protein combined preparation comprises the following steps: preparing anti-propionibacterium acnes gamma protein; adding water into the anti-propionibacterium acnes gamma protein and the recombinant III-type collagen, stirring and mixing, adding glycerol and a neutralizing agent, and mixing to obtain a uniform solution; the preparation method comprises the following steps: dispersing carbomer with water, adding a preservative and a humectant, mixing, finally adding the uniform solution, and mixing to obtain the required collagen and anti-propionibacterium acnes gamma protein combined preparation. The combined preparation prepared by the method can be used for effectively treating acnes, is remarkable in curative effect, does not generate drug resistance, is short in treatment cycle, can quickly eliminate skin damage, promote cell growth and adhesion and repair skin barriers, and does not generate new rash after healing.

The invention relates to the field of medical dressings, in particular to a transdermal drug delivery dressing and a preparation method thereof. The dressing comprises carbomer, carboxymethyl chitosan, sodium polyacrylate, sodium tripolyphosphate, triethanolamine and water, and the content of each component is limited. According to the invention, a'carbomer-triethanolamine 'and'carboxymethyl chitosan-sodium tripolyphosphate' double-gel system is ingeniously constructed, and the moisturizing and enhancing effects of sodium polyacrylate are supplemented; the transdermal delivery hydrogel dressing which integrates excellent adhesion, good mechanical strength, lasting moisturizing capacity, excellent biocompatibility and wide drug adaptability is successfully developed. According to the dressing, the common key problems of poor gel stability, skin irritation risk, limited drug loading, poor process reproducibility and the like in the prior art are effectively solved, and a solution with a great application prospect is provided for developing a new generation of efficient, safe and comfortable transdermal drug delivery products.

According to the graft modified carbomer and the preparation method and application thereof, based on the chemical reactivity of carboxyl of carbomer and amino / catechol group (and oxidation product quinonyl) of dopamine, through amidation, Michael addition and other covalent bond formation reactions, grafting of micromolecular functional groups to a high-molecular main chain is achieved, the hydrophilicity of carbomer can be enhanced, and the hydrophilicity of the carbomer can be enhanced; the wettability of water to the carbomer particles is improved; agglomeration is avoided, so that water phase permeation and molecular chain dispersion are accelerated, and the dissolution time is shortened; the net-shaped structure is more compact, and the amount of wrapped water is increased, so that the viscosity of the system is obviously improved; the dopamine is grafted to the carbomer, so that the modified carbomer has excellent biological activity and is more suitable for the field of biomedicine, the defects of long dissolution time, insufficient viscosity stability and the like of the carbomer in the prior art are effectively overcome, and the application prospect is wide.

The invention belongs to the technical field of dressings, and particularly relates to a gel dressing containing recombinant collagen as well as a preparation method and application of the gel dressing. The gel dressing containing the recombinant collagen is prepared from the following raw materials in percentage by weight: 0.1 to 1 percent of the recombinant collagen, 0.5 to 1 percent of sodium hyaluronate, 0.08 to 0.15 percent of radices stellariae dichotomae cyclopeptide, 0.5 to 1 percent of carbomer, 0.03 to 0.06 percent of cryptomeria fortunei bud extract, 15 to 20 percent of poloxamer, 0.1 to 0.5 percent of xanthan gum, 3 to 8 percent of glycerol, 0.04 to 0.08 percent of edetate disodium, 0.1 to 0.3 percent of triethanolamine, 0.08 to 0.12 percent of preservative and the balance of deionized water. The gel dressing has excellent biocompatibility, good hemostasis, cell growth promotion and tissue repair performance, and can be used for repairing vaginal mucous membrane chap and hemostasis of diffuse superficial bleeding, and improving the symptoms of elasticity reduction and the like caused by vaginal atrophy.

The application discloses an anti-hair-loss original solution containing transdermal recombinant collagen and a preparation method thereof. The anti-hair-loss original solution comprises the following components in percentage by mass: 0.5-2% of recombinant collagen glycerol, 2-10% of glycerol, 0.5-5% of 1,2-hexanediol, 0.5-6% of p-hydroxyacetophenone, 0.1-0.7% of sodium hyaluronate, 0.5-5% of 1,2-pentanediol, 0.05-2% of aminomethylpropanol, 0.05-2% of plant soothing agent SGS, 0.1-2% of carbomer U21, and the rest is water. The application uses the glycerol encapsulation technology to encapsulate the high-activity recombinant collagen in the glycerol vesicle, improves the transdermal property of the recombinant collagen, and forms the anti-hair-loss original solution by compounding the transdermal recombinant collagen as the active component with other raw materials, which has the effects of moisturizing and water-locking the skin and preventing hair loss.

The invention provides the preparation method of the radiation-resistant carbomer, the preparation method of the radiation-resistant carbomer is simple, rapid and efficient, the carbomer structure is effectively controlled by regulating and controlling the ratio of a copolymerized hydrophobic monomer and the content of allyl polyol, vinyl polysiloxane, a cross-linking agent and monoallyl ether are copolymerized on a carbomer chain segment, and the radiation-resistant carbomer is prepared. Meanwhile, the ratio of carboxylate to carboxylate radicals is adjusted, hydrophilicity is improved, wetting of carbomer is accelerated, interaction of hydroxyl groups on a carbomer structure after neutralization is enhanced, the combination effect with water is enhanced, and meanwhile, by means of the low polarity and caging effect of polysiloxane chain segments, the high radiation resistance and ion resistance are achieved. The obtained radiation-resistant carbomer has the characteristics of high viscosity, high wetting speed, good ion resistance, high transparency, good radiation resistance and the like.

The invention discloses a gel composition for repairing female genital tracts as well as a preparation process and application of the gel composition. The composition comprises three functional core systems: a polysaccharide-enzyme compound A which is formed by self-assembly of superoxide dismutase and oxidative degradation modified aloe polysaccharide and has antioxidant and microenvironment regulation functions; a metal ion-polysaccharide slow-release antibacterial body B formed by coordination of zinc ions and low-molecular-weight chitosan provides instant and long-acting antibacterial protection; the plant polyphenol-protein tissue repair body C is formed by non-covalent binding of epigallocatechin gallate and hydrolyzed collagen, and tissue regeneration and functional reconstruction are promoted. The three components are compounded according to a mass ratio of (1-2): (0.5-1): (2-4), and are integrated with a carbomer matrix to form stable gel. The invention further provides a specific preparation process and a synergistic effect mechanism of all the components. The gel has good stability, biocompatibility and repairing efficiency, and is suitable for treating or improving female genital tract mucosa lesion, inflammation or flora imbalance.

The present application provides a kind of preparation method of carbomer, comprising the following steps: (1) acrylic monomer is added to mixed solvent, inert gas is introduced, then photo initiator, dispersing agent and polyene crosslinking agent are added, after stirring under ultraviolet lamp for a period of time, dropwise addition of thermal initiator, reaction for a period of time, add multi mercapto crosslinking agent, control reaction temperature and continue to react;(2) filter and wash the reaction product, dry to obtain carbomer.The preparation method of the present application carbomer is simple, fast and efficient, without heating, rely on ultraviolet lamp and reaction process to provide reaction temperature, while introducing mercapto-alkene reaction, reaction efficiency is high, the molecular weight of polymer is improved.The reaction process is not only safe and pollution-free, but also the product has high molecular weight, low residual single content, low product odor, enhanced ultraviolet resistance, high viscosity and good transparency.

The invention provides a powder carbomer polymer as well as a preparation method and application thereof. The powder carbomer is obtained by polymerizing an acrylate monomer containing unsaturated double bonds in a solvent in the presence of a cross-linking agent and a free radical initiator, wherein the acrylate monomer containing the unsaturated double bonds does not react completely, and the reaction degree of the acrylate monomer containing the unsaturated double bonds is 60-95%. According to the method, the thickening efficiency, transparency and ion resistance of the carbomer in practical application can be effectively improved, and meanwhile, the suspension performance of the carbomer in formula use is improved.

The present invention relates to a composition, in particular a cosmetic composition, comprising a fluid gelling aqueous phase comprising a salt and two hydrophilic gelling agents capable of gelling in the presence of the salt wherein the composition is free of carbomer, the composition further comprising a fat phase in the form of droplets dispersed in a continuous aqueous phase, the fat phase and the aqueous phase are immiscible, droplets having a diameter greater than or equal to 100 [mu] m comprise greater than or equal to 60% by volume of the total volume of the dispersed fat phase, and / or at least 60% of the droplets have an average diameter greater than or equal to 100 [mu] m. The invention is useful for the non-therapeutic care of keratin substances such as skin and hair.

The invention relates to the technical field of oral care products, in particular to gel with excellent ion resistance and a preparation method thereof. The gel with excellent ion resistance is characterized by being prepared from the following raw materials in parts by weight: 1-10 parts of a biological gelling agent, 0.1-8 parts of an ion component, 0.01-5 parts of an auxiliary gelling agent, 1-30 parts of a humectant and 0.1-5 parts of a pH (Potential of Hydrogen) regulator, the biological gelling agent comprises at least one of carbomer and poloxamer; the Carbomer comprises at least one of a Carbomer 974 NF, a Carbomer 980 NF, a Carbomer ETD2020 NF, and a Carbomer Ultratrez10 NF, and the number of the Carbomer is at least one. According to the technical scheme, the technical problem that in the prior art, an oral desensitization gel which is ideal in biocompatibility, ion-resistant stability, rheological property, rapid desensitization and tooth demineralization inhibition effect and simple and feasible in preparation process is lacked is solved, and the oral desensitization gel has ideal popularization and application prospects.

The invention discloses hydrogel, a preparation method thereof and a product for promoting reconstruction and repair of a fungal infection wound epidermis-dermis connection structure based on the hydrogel. The product comprises a copper ion compound solution, sodium alginate, carbomer and a pH regulator, in the copper ion compound solution, the concentration of copper ions is 0.01%-0.1%; by mass, 0.5%-1.5% of sodium alginate and 0.1%-0.5% of carbomer are added into every 100 mL of the copper ion compound solution, and the pH value of the copper ion compound hydrogel is adjusted to 4.0-5.5 by the pH regulator. Compared with traditional antibiotics or high-concentration copper salt, the problems of false healing and easy recurrent tearing caused by fragile structure after the wound infected by fungi is healed are fundamentally solved, the safety window of treatment is obviously widened, drug resistance is not easy to generate, and a new strategy is provided for treating intractable fungal infection mediated by a biological membrane.

The invention relates to a method for detecting the content of carbomer in a medicinal preparation, which is used for solving the problems of high detection cost and auxiliary material interference in the prior art. According to the method, urea and guanidine organic alkali are added in sample pretreatment, so that the influence of preparation auxiliary materials on the neutralization reaction of carbomer is weakened; according to the method, excessive berberine is adopted to be fully combined with carboxylic acid groups in the carbomer, then the residual concentration of the berberine is detected, and a linear relation of the reaction of the carbomer and the berberine is established, so that the content of the carbomer in a sample is calculated. The detection method established by the invention is suitable for different preparation formulas, is more flexible in detection means, and is suitable for industrial popularization.

The present application relates to a kind of salt-tolerant carbomer and its preparation method and application, the preparation raw material of the carbomer includes the following weight parts of component: acrylic monomer 8-12 parts, cyclohexane 30-70 parts, ethyl acetate 30-70 parts, thickening agent 0.12-0.8 parts, initiator 0.01-0.2 parts and crosslinking agent 0.05-0.3 parts.The salt-tolerant carbomer prepared by the present application has certain salt tolerance, can be better applied in solid preparation, semi-solid preparation and liquid preparation in medicine and daily chemical product, mainly used as adhesive, suspending agent, thickening agent etc., has great application value and scientific research significance.

This invention discloses an excipient matrix suitable for weakly acidic mucosal environments, its preparation method, and its application, relating to the field of pharmaceutical excipient technology. The matrix includes polycarbophen, carbomer, a dynamic site polymer containing benzo[a]oxoborazole or boron-oxygen heterocyclic groups, a competing diol blocking agent, a diol donor polymer, and a buffer system. The pH of the excipient matrix is ​​4.0–4.4. After contact with the weakly acidic mucosal fluid, the dynamic site polymer, the diol donor polymer, and the mucosal glycan diol sites form a dynamic reversible crosslinking network. The ratio of the total molar amount of diol hydroxyl groups in the competing diol blocking agent to the total molar amount of boron atoms in the dynamic site polymer is 1.2:1–3.5:1. This invention maintains the structural stability of the matrix by reversibly blocking dynamic sites under storage conditions using a competing diol blocking agent.

The application discloses a sustained-release gynecological gel containing recombinant human collagen peptide and a preparation method thereof, and belongs to the field of biological medicines. The preparation method comprises the following steps: stirring and mixing collagen peptide compound, carbomer, copaiba balsam oil and purified water to obtain a mixed emulsion, and then adding sodium alginate to stir and react to prepare the sustained-release gynecological gel containing the recombinant human collagen peptide. The sustained-release gynecological gel containing the recombinant human collagen peptide has the advantages of preventing the occurrence of adhesion by physical isolation of the gel, being beneficial to maintaining the stability of collagen and copaiba balsam oil, slowly and long-acting releasing, good stability, high bioavailability, effectively reducing the postoperative recurrence rate, good biocompatibility, excellent biodegradability, good tolerance, safety and effectiveness, and convenient use.