4 results about "Carbo-mer" patented technology

The application relates to the technical field of functional materials, and discloses a preparation method of a silver-based metal-organic framework hydrogel composite material and application of the silver-based metal-organic framework hydrogel composite material in antibiosis, which comprises the following steps: respectively dissolving silver nitrate and 3-methyl-5-trifluoromethyl-1H-1,2,4-triazole in 5 milliliters of 5% ammonia water according to a molar ratio of 1:1; synthesizing by adopting an interfacial synthesis method, with 5 milliliters of 5% ammonia water as an intermediate layer; avoiding light and standing; adding the silver-based metal-organic framework material into distilled water, and ultrasonic dispersing for a second preset time length; mixing with carbomer with a concentration of 9.8 grams per liter, adding triethanolamine with a concentration of 5 grams per liter when the solution becomes clear; and stirring at a second mixing rate until a uniform gel is formed. The silver-based metal-organic framework hydrogel composite material prepared by the application has excellent antibacterial activity, biocompatibility, appropriate mechanical properties and adhesion, stable rheological properties, and is stronger than a commercial AgNPs-gel.

The invention relates to the technical field of biological medicine, and particularly discloses a preparation method of a collagen and anti-propionibacterium acnes gamma protein combined preparation, and the preparation method of the collagen and anti-propionibacterium acnes gamma protein combined preparation comprises the following steps: preparing anti-propionibacterium acnes gamma protein; adding water into the anti-propionibacterium acnes gamma protein and the recombinant III-type collagen, stirring and mixing, adding glycerol and a neutralizing agent, and mixing to obtain a uniform solution; the preparation method comprises the following steps: dispersing carbomer with water, adding a preservative and a humectant, mixing, finally adding the uniform solution, and mixing to obtain the required collagen and anti-propionibacterium acnes gamma protein combined preparation. The combined preparation prepared by the method can be used for effectively treating acnes, is remarkable in curative effect, does not generate drug resistance, is short in treatment cycle, can quickly eliminate skin damage, promote cell growth and adhesion and repair skin barriers, and does not generate new rash after healing.

The application discloses an anti-hair-loss original solution containing transdermal recombinant collagen and a preparation method thereof. The anti-hair-loss original solution comprises the following components in percentage by mass: 0.5-2% of recombinant collagen glycerol, 2-10% of glycerol, 0.5-5% of 1,2-hexanediol, 0.5-6% of p-hydroxyacetophenone, 0.1-0.7% of sodium hyaluronate, 0.5-5% of 1,2-pentanediol, 0.05-2% of aminomethylpropanol, 0.05-2% of plant soothing agent SGS, 0.1-2% of carbomer U21, and the rest is water. The application uses the glycerol encapsulation technology to encapsulate the high-activity recombinant collagen in the glycerol vesicle, improves the transdermal property of the recombinant collagen, and forms the anti-hair-loss original solution by compounding the transdermal recombinant collagen as the active component with other raw materials, which has the effects of moisturizing and water-locking the skin and preventing hair loss.

This invention discloses an excipient matrix suitable for weakly acidic mucosal environments, its preparation method, and its application, relating to the field of pharmaceutical excipient technology. The matrix includes polycarbophen, carbomer, a dynamic site polymer containing benzo[a]oxoborazole or boron-oxygen heterocyclic groups, a competing diol blocking agent, a diol donor polymer, and a buffer system. The pH of the excipient matrix is ​​4.0–4.4. After contact with the weakly acidic mucosal fluid, the dynamic site polymer, the diol donor polymer, and the mucosal glycan diol sites form a dynamic reversible crosslinking network. The ratio of the total molar amount of diol hydroxyl groups in the competing diol blocking agent to the total molar amount of boron atoms in the dynamic site polymer is 1.2:1–3.5:1. This invention maintains the structural stability of the matrix by reversibly blocking dynamic sites under storage conditions using a competing diol blocking agent.