54 results about "Carbo-mer" patented technology

The invention discloses a hyaluronic acid dressing and a preparation method thereof. The dressing comprises the following components in percentage by mass: 0.01-0.3% of medium-molecular-weight hyaluronic acid, 0.01-0.5% of small-molecular-weight hyaluronic acid, 0.03-1% of allantoin, 0.1-1% of Carbomer, 2-5% of sorbitol, 0.2-1% of trehalose, 0.7-2.5% of witch hazel distillate, 0.1-0.5% of D-panthenol, 0.05-0.15% of alpha-bisabolol, 0.2-1.0% of oat glucan, 2-10% of glycerinum, 0.06-1% of water-soluble silicon wax, 0.05-0.9% of an antalkali, 0.004-0.2% of 2-methyl-4-isothiazoline-3-one, 0.05-0.4% of phenoxyethanol, 0.005-0.05% of pentanediol, 0.01-0.06% of octylene glycol, 0.025-0.5% of methylparaben and the balance of water. The dressing disclosed by the invention is capable of permeating into the deep layers of the skin to remove excessive free radicals, promoting the generations of blood vessels, and accelerating the union of wounds, in particular, acnes, eczematous dermatitis, photorejuvenation postoperation repair and the like.

The present application describes improved an immunogenic compositions of virus vaccines wherein the virus vaccines comprise adjuvants selected from the group consisting of MCP-1, Haemophilus sonmus fractions, carbomer and combinations thereof. Methods and compositions using such improved compositions are described.

The invention relates to gel containing triclosan. The gel containing the triclosan is characterized in that ethyl alcohol does not exist in the gel. The gel containing the triclosan takes the triclosan as a germicidal component, and by means of the technological means of nanoemulsion, the problem that the triclosan is difficult to dissolve in water is solved; carbomer serves as a gel matrix, and a gel preparation which is clear and transparent in appearance is obtained finally. The gel containing the triclosan can be used for the medical fields such as skin sterilization, treatment on gynecological diseases and medical ultrasonic coupling agents.

The invention relates to an ultrasonic coupling agent and a preparation method thereof. The ultrasonic coupling agent comprises the following raw materials: triclosan, an F3 solubilizer, glycerin, carbomer, triethanolamine and purified water. The ultrasonic coupling agent is colorless and transparent, does not contain an air bubble or contains a few of air bubbles, is moderate in viscosity, is capable of rapidly killing a plurality of pathogenic organisms, such as germs, viruses and bacteria, and is free of cytotoxicity on skin, free of thrill, free of sensitization, excellent in sound-conducting property and clear in ultrasonic image. The formula and the technological processes are adopted; the used material components are simple; the preparation technology is simple and convenient; and large-scale production can be realized.

The present invention relates to a progestogen composition. Said progestogen composition is formed from 27-31% of fluoropregestin, 2-2.7% of ethinyl estradiol, 8-10% of lauric acid, 37-40% of ethyl alcohol, 0.3-0.6% of carbomer and 6-10% of propylene glycol, and the rest is pure water. Besides, said invention also provides the delayed-release suppository device of said progestogen composition and its preparation method.

The invention discloses a caprine placental peptide-bone collagen polypeptide composition. The caprine placental peptide-bone collagen polypeptide composition is characterized by being prepared from the following components in percentage by mass: 1 to 3 percent of dipropylene glycol, 3 to 8 percent of glycerinum, 0.5 to 1 percent of glycerinum polyacrylate, 1 to 3 percent of xanthan gum, 0.5 to 1percent of panthenol, 1 to 3 percent of carbomer, 0.5 to 1 percent of nicotinamide, 0.5 to 1 percent of dipotassium glycyrrhizinate, 0.05 to 1.5 percent of hydrolyzed caprine placenta extract, 0.3 to0.5 percent of caprine placental peptide, 0.2 to 0.3 percent of bone collagen popypeptide, 0.05 to 1.5 percent of hydrolyzed collagen, 1 to 3 percent of aloe barbadensis leaf juice, 3 to 6 percent ofchamomilla recutita flower extract, 0.5 to 1 percent of beta-glucosan, 0.5 to 1 percent of arginine, 0.05 to 1.5 percent of hyaluronic acid, 0.5 to 1 percent of oligopeptide-1, 0.5 to 1 percent of palmitoyl pentapeptide-4, 0.5 to 1 percent of palmitoyl tripeptide-5, 1 to 3 percent of saccharide isomerate, 1 to 3 percent of papain, 0.5 to 1 percent of tridecanol polyether-9, 2 to 5 percent of melissa officinalis flower / leaf / stem water, 1 to 3 percent of rosemary leaf water, 0.05 to 0.5 percent of methylparaben, 0.05 to 0.5 percent of EDTA disodium, 0.01 percent of essence and the balance of water. By adopting the caprine placental peptide-bone collagen polypeptide composition, the caprine placental peptide-bone collagen polypeptide composition is prepared into the mask liquid, the skin elasticity is enhanced, moisture is kept effectively, small wrinkles on the skin can be tightened and softened, so that the skin is smooth.

The invention discloses a preparation method of an antifungal imidazole medicament controlled-release gel. The preparation is mainly used for vaginal administration and treatment on colpomycosis and other diseases and belongs to the technical field of medicaments. The antifungal imidazole medicament controlled-release gel is prepared from the following raw materials in parts by weight: 0.5-3 parts of imidazole medicaments, 0.5-2 parts of polycarbophil, 0.5-2 parts of carbomer, 0.2-1.0 part of lipid component, 1-2 parts of emulsifying agent, 5-15 parts of wetting agent and 80-100 parts of water. The preparation method has the advantages that the medicament is slowly released, local durable concentration of the medicament is kept, the sterilizing effect is enhanced, the medicament application frequency is reduced, and the stimulation to the medicament is reduced.

The invention discloses a preparation method and application of composite liquid for preventing and killing avian influenza viruses H5N1 and H1N1 for a long time. According to the formula, the composite liquid is prepared from 1,000mg-2,000mg of carbomer gel, 1,000mg-2,000mg of triethanolamine, 1,000mg-2,000mg of sophora flavescens and cortex phellodendri, 4g-6g of eucalyptus oil and 1,600mg-2,500mg of nano silver in 1L of pure water, wherein nano silver consists of high-purity (9999) spherical elementary substance nano silver powder particles with the particle sizes of 1nm-5nm. The invention also discloses the preparation method and the application of the solution. The composite liquid disclosed by the invention can be applied to low-concentration spraying after being diluted by a general sprayer till the silver content of the liquid is not greater than 1.17mg / L.

The invention relates to a macromolecular hydrophilic gel and a preparation method and application thereof. The gel is made of Carbomer mixed with purified water, glycerinum and polysorbate, the pH value is adjusted by using sodium hydroxide solution, and the gel with negative electricity is prepared. The macromolecular hydrophilic gel has irregular bubbles, no stimulation and no other macroscopicexogenous impurities, and is transparent, in a viscous colloid shape and free from extraneous odor, the pH value is equal to 6.30-9.37, the dynamic viscosity is 5000-7000 mPa s, the microbial contentis 10 cfu / g, the total effective rate for allergic rhinitis patients in a clinical test can reach about 90%, and the effective rate of an on-sale congeneric product Mobijing as a control group is nomore than 70%; it is shown that compared with the congeneric product, the macromolecular hydrophilic gel can cure allergic rhinitis better, and has a good preventive and adjuvant therapeutic effects on the allergic rhinitis.

The invention discloses anti-oxidation and anti-aging whitening gel and a preparation method thereof.The whitening gel comprises a first matrix, a second matrix and base solution, wherein first matrixcomprises the following components by mass: 6-10 parts of glycerinum, 0.5-1 part of carbomer, 0.1-1 part of triethanolamine and 0.1-1 part of polydimethylsiloxane; the second matrix compriss the following components in parts by mass: 30-50 parts of chitosan and 30-50 parts of gelatin. Through arrangement of the base solution, the second matrix and the first matrix, the heat-sensitive release basesolution of the second matrix enters the first matrix, the gel slowly and uniformly releases effective components, the action time of the components is prolonged, the adaptability of the skin to thegel is improved, and absorption and utilization of the gel by the skin are promoted; multiple components are added, mutual promotion among the components is achieved, the activity of free radicals isinhibited, the free radicals are eliminated, the generation of melanin is inhibited, metabolism is promoted, exfoliated melanin is removed, the anti-oxidation, anti-aging and whitening effects of thegel are achieved, and the gel is suitable for being widely popularized and used.

The invention discloses a stable weakly acidic whitening agent composition and a preparation method thereof. The stable weakly acidic whitening agent composition comprises the following raw materialsin parts by weight: 5-10 parts of 3-o-ethyl ascorbyl ether, 3-6 parts of nicotinamide, 2-5 parts of alpha-arbutin, 1-3 parts of butanediol, 1-3 parts of an emulsifier, 0.5-2.0 parts of jojoba seed oil, 0.5-2.0 parts of meadowfoam seed oil, 0.5-2.0 parts of tocopheryl acetate, 0.1-0.5 part of carbomer, 0.1-0.5 part of triethanolamine, 0.01-0.05 part of citric acid and the balance of water, whereinall the raw materials are 100 parts. Intervention and damping are performed on the whole stages of the initial stage, the middle stage and the final stage of melanin formation respectively, besides, the preparation method further performs micro-emulsification wrapping on the four whitening components to improve the stability of the four whitening components, and in addition, by adjusting the pH value, the absorptivity of the whitening agent, the compatibility of the skin and the stability of the whitening agent are improved. Therefore, the whitening agent which inhibits tyrosinase activation in the initial stage, inhibits oxidative antagonism in the middle-stage conversion process and prevents melanin transportation in the final stage, and is high in comprehensive skin absorptivity and extremely high in stability is obtained.

The invention discloses a foaming agent for vaginal packing. Raw materials for the foaming agent comprise, by weight, 0.1 to 2.0 parts of carbomer, 1.0 to 3.0 parts of zirconium phosphate-loaded silver or nanometer silver, 1.0 to 5.0 parts of glycerin, 1.0 to 5.0 parts of propylene glycol, 0.2 to 5.0 parts of triethanolamine, 96.69 to 78 parts of purified water, 0.01 to 2.0 parts of fibronectin (FN), 0.1 to 3.0 parts of paeonol and 0.1 to 3.0 parts of matrine. A propellant comprises 0 to 15 parts of n-butane, isobutane and / or n-propane, or 0 to 20 parts of dimethyl ether, or 0 to 15 parts of fluoroalkane, or 0 to 15 parts of Freon. According to results of clinical practice, therapeutic effects of the foaming agent provided by the invention are substantially superior to those of traditional therapy, and a treatment course needed in the invention is shorter than that of conventional therapy.

The invention relates to a determination method of carbomer content in gel containing carbomer. The determination method is characterized by comprising the following steps: adding a certain amount of an alkaline solution to enable a carboxylic acid group of the carbomer in the gel to exist at an ion state; then adding an excessive amount of a metal salt solution and sufficiently mixing metal salt and the carboxylic acid group in the carbomer to generate a complex; after removing the complex, titrating unbound metal salt by utilizing an EDTA (Ethylene Diamine Tetraacetic Acid) titrating solution, so as to calculate the content of the carbomer in a sample. The method provided by the invention is applicable to detection of the carbomer content in the gel which takes the carbomer as a gel matrix or a main component; the method is simple and accurate and has strong specificity.

The invention discloses a small-molecule hyaluronic acid and a preparation method thereof, wherein the small-molecule hyaluronic acid comprises the following components in mass percent: 0.1-5% glycerin, 0.1-10% propylene glycol, 0.1-10% butanediol, 0.1% ~1% fruit peel extract, 0.1~1% hydrolyzed sodium hyaluronate, 0.1~5% glycerol glucoside, 0.1~5% glucosaminoglycan, 0.1~10% hydrolyzed collagen, 0.1~1% carbomer , 0.1-1% triethanolamine, 0.1-2% bis(hydroxymethyl) imidazolidinyl urea, 0.1-1% iodopropynyl butyl carbamate, and the balance is deionized water. The present invention also provides a preparation method of small molecule hyaluronic acid, comprising 1) preparing citrus peel extract for standby use, 2) batching, 3) raising the temperature to prepare stock solution, 4) preparing crude product, and 5) improving quality. The hyaluronic acid prepared by the invention has a molecular weight of 500,000 to 800,000 daltons, which is beneficial to the skin's absorption, and simultaneously adopts fruit peel extracts and easy-absorbed organic matter, which is beneficial to the health of the skin.

The invention relates to a preparation method of bacteriostatic gel. The preparation method specifically comprises the following steps of 1) weighing 200g of radix sophorae flavescentis, 180g of cortex phellodendri, 180g of fructus cnidii, 80g of flos carthami and 50g of herba menthae, and cleaning for later use; 2) paste preparation; 3) taking 3g of ethylparaben, and adding ethanol into the ethylparaben to dissolve the ethylparaben to obtain an ethylparaben solution for later use; 4) taking 0.3 g of polyhexamethylene biguanide, and adding purified water into the polyhexamethylene biguanide todissolve the polyhexamethylene biguanide to obtain a polyhexamethylene biguanide solution for later use; 5) taking 20g of carbomer, adding purified water into the carbomer, and soaking for 24 hours until the carbomer is fully swollen to obtain a gel matrix for later use; 6) burdening; and 7) filling, packaging, checking and putting in storage. The preparation method has the advantages that the bacteriostatic gel is convenient to prepare, the average antibacterial rate of the bacteriostatic gel for staphylococcus aureus, candida albicans and escherichia coli is 50% or above, and the bacteriostatic gel has a remarkable effect on diseases such as pruritus vulvae, waist and abdomen pain, abnormal leucorrhea, vaginitis, vulvitis, pelvic inflammation, salpingitis and the like.

The invention discloses a composition having moisturizing and soothing effects and a facial mask thereof. The composition is prepared from the following components by weight percent: 3.0-7.0% of butanediol, 2.0-8.0% of glycerol, 1.5-7.0% of a mixture of glycosyltrehalose and hydrogenated starch hydrolysate, 0.5-1.0% of Cladosiphon Okamuranus extract, 0.1-0.3% of carbomer, 0.1-0.3% of triethanolamine, 0.1-0.3% of dipotassium glycyrrhizinate, 0.06-0.15% of methylparaben, 0.06-0.15% of sodium hyaluronate, 1.0-2.5% of dianthus chinensis extract and peony root bark extract, 0.02-0.07% of ganoderma lucidum extract, 0.008-0.01% of methylisothiazolinone, and the balance of water, wherein a weight ratio of the glycosyltrehalose to the hydrogenated starch hydrolyzate is 3:1, and a weight ratio of the dianthus chinensis extract to the peony root bark extract is 4:6. The composition disclosed by the invention is non-irritating to the skin, has an obvious moisturizing effect, significantly inhibits inflammation and alleviates allergies, increases skin resistance, and moisturizes and tightens the skin.

The invention relates to a zuojin microemulsion-based gel for treating stomachache and a preparation method thereof. Particularly, the Chinese herbal compound microemulsion-based gel comprises the following components in parts by weight: 0.1-1.0 part of zuojin extract, 100 parts of microemulsion matrix, and 100 parts of gel matrix, wherein the zuojin extract is prepared from coptidis rhizoma and fructus evodiae through extracting according to the weight ratio of 6:1; the microemulsion matrix is composed of the following components according to a weight ratio: 2.5-7.5% of oil phase (MCT), 5-25% of a surfactant (RH-40), 5-15% of a cosurfactant (PEG-400) and the balance of water; the gel matrix is composed of the following components according to a weight ratio: 0.3-2.0% of Carbo-mer, 0.5-2.0% of hydroxypropyl methyl cellulose, 0.6-1.8% of povidone, 5-25% of polyethylene glycol-400, 0.3-1.2% of triethanolamine, 0.03-0.08% of sodium bisulfite, 0.02-0.05% of ethylenediamine tetraacetic acid disodium salt and balance of water. The zuojin microemulsion-based gel has no irritation and irritability, has a higher percutaneous penetration rate, is more stable, is suitable for being applied externally and can achieve the effect of treating the internal illness by external treatment.

The invention discloses a nano-metal oxide-minocycline nano sustained-release gel as well as a preparation method and application thereof. In accordance with the current situations of a minocycline local preparation which is insufficient in drug release stability and effectiveness, and the like, the water-soluble gel sustained-release agent is prepared by covering active metal oxide nano molecules and minocycline hydroxide with a biodegradable high polymer material by taking carbomer as a substrate; the sustained-release agent is good in stability and good in moisture retention, and the sustained-release agent has the advantages of being capable of lowering drug content, enhancing an antibacterial effect and prolonging a drug action time, and being capable of achieving targeted localization, easy to operate, low in cost and the like; the sustained-release gel is more suitable for treating acute and chronic periodontal disease and gingivitis; and the sustained-release gel has good market and economic benefits.

The invention discloses a retina containing new zealand spinach polypeptide. The retina is prepared from the following ingredients in percentage by weight: 0.4-1% of the new zealand spinach polypeptide, 6-9% of glycerol, 0.2-0.4% of carbomer, 0.05-0.09% of sodium polyacrylate / polyethylene glycol-5M, 0.25-0.5% of sodium hyaluronate, 0.25-0.3% of triethanolamine, 0.2-0.4% of butanediol / water / peony root extract, 0.002-0.005% of diazolidinyl urea / iodic propynol-butyl Kinavosyl, 0.003-0.004% of methylisothiazolinone / iodicpropynol-butyl Kinavosyl, and the balance of deionized water, wherein the new zealand spinach polypeptide is prepared by enzymolysis based on neutral proteinase, papain and barley endopeptidase. The retina prepared by use of the new zealand spinach polypeptide not only is good in moisture preservation effect, but also has the effects of resisting wrinkles, repairing tissue damage and alleviating edema symptoms, and can be used for promoting cell regeneration, tensioning canthus skin and relieving pouches.

The invention relates to a detection method of drug protein content in drug gel, and is characterized in that when drug protein is released from gel, the gel is diluted or not diluted at first; a solution containing calcium ions is added as a releaser, wherein the calcium ion adding concentration range is 0.015 mol / L-0.15 mol / L. The gel is precipitated rapidly, and the drug protein is released completely from the gel, which enables more accurate determination of the drug protein content in the drug, and the biological activity titer. The method is suitable for the detection of drug protein content in gel drugs with carbomer used as a gel matrix, such as the detection of rh-bFGF content in recombinant human basic fibroblast growth factor gel. The method is simple, accurate, and strong in repeatability.

The present invention discloses a skin cleansing and purifying membrane and a preparation method thereof. The skin cleansing and purifying membrane comprises the following ingredients in weight percentages: 60-70% of water, 3-6% of glycerin, 1-4% of polydimethylsiloxane, 6-9% of propylene glycol, 1.6-1.9% of isohexadecane, 1.4-1.7% of polysorbate-80, 1.7-2.0% of nicotinamide, 2.5-2.8% of butanediol, 0.15-0.18% of carbomer, 0.4-0.7% of hydroxyethyl cellulose, 0.3-0.6% of triethanolamine, 0.4-0.7% of sodium hyaluronate, 0.07-0.10% of methylparaben, 0.1-0.4% of hyaluronic acid, 0.2-0.5% of phenoxyethanol and 0.5-0.8% of essence. The product of the skin cleansing and purifying membrane is evenly applied on the face for 10-15 min, presents a transparent state in absorption, is then used to massage the whole face, discharges waste residues, can rapidly penetrate the dermis, repairs damaged cells, decomposes accumulated excessive oil, melanin and dead cells in a deep layer of pores, removes toxic substances and cosmetic residues, promotes metabolism and decomposition of melanin in the deep layer, enables skin tissue cells to re-grow, increases elasticity of the dermis, promotes cell regeneration, shrinks the pores, whitens the skin and fades spots, fades wrinkles and enables the skin to be smooth and firm.

The invention discloses anti-aging essence and a preparation method thereof. The essence is prepared from the following components in percentage by mass: 1-3% of laminarin; 0.5-2.5% of rhizoma polygonati polysaccharide; 1-3% of lentinan; 2-8% of isopropyl myristate; 2-10% of caprylic capric triglyceride; 1%-5% of hydrogenated castor oil, 2%-8% of polyethylene glycol, 1%-2% of polydimethylsiloxane,0.01%-0.05% of carbomer, 4%-10% of glycerinum, 0.01%-0.05% of hyaluronic acid, 2%-6% of xylitol, 0.02%-0.1% of methylparaben, 0.01%-0.1% of essence and the balance of deionized water. The anti-agingessence is prepared from laminarin, polygonatum kingianum polysaccharide and lentinan through reasonable compatibility, scientific proportioning and matching with other raw materials, has the advantages of mildness, no irritation and no toxic or side effect, and can make the skin moisturized, compact and elastic after long-term use.

The invention discloses a whitening composition and application thereof. The invention further discloses a whitening cosmetic prepared from the whitening composition, and the whitening cosmetic is prepared from the following components in percentage by mass: 0 to 2% of glutathione, 0 to 5% of hydroxyapatite, 0 to 2% of an amino acid stabilizer, 0 to 1% of proteoglycan, 0 to 2% of 4-butylresorcinol, 0 to 5% of glycerol, 0 to 4% of methylpropanediol, 0 to 2% of butanediol, 0 to 2% of 1, 2-pentanediol, 0 to 0.1% of sodium polyglutamate, 0 to 0.2% of carbomer, 0 to 0.2% of sphingosine gum, 0 to 2% of glyceryl polyether-26, 0 to 2% of PEG / PPG-17 / 6 copolymer, 0 to 0.5% of p-hydroxyacetophenone and the balance of water. By regulating and controlling the proportion of hydroxyapatite / cysteine / proteoglycan in the whitening composition and synergistic compatibility of the components, the odor of glutathione can be eliminated, meanwhile, 4-butylresorcinol is stabilized, the stability of 4-butylresorcinol is improved, and the irritation of 4-butylresorcinol is reduced; the obtained whitening product is ensured to have the minimum smell, the minimum color change, the minimum irritation and the best whitening effect, and the performance in all aspects is optimal.

The invention discloses gelata for treating cervicitis and cervical erosion. The gelata is prepared from the following raw materials in parts by weight of 0.1-0.5 part of an antioxidant, 0.1-0.5 partof ethylenediamine tetraacetic acid disodium salt, 80-90 parts of deionized water, 2-5 parts of carbomer, 2-5 parts of Yipiwutai, 40-50 parts of ethanol,13-15 parts of a hydrating agent, 6-8 parts ofa surfactant, 2-5 parts of laurocapram and 3-6 parts of a pH-regulating agent. In the process of preparing the gelata, the surfactant is prepared, and the surfactant molecule contains hydrophilic groups and hydrophobic groups, so that when the surfactant molecule is in contact with the surfaces of cells, the surfactant molecule and a cell membrane mutually dissolve, phospholipid molecules on the cell membrane cannot be arrayed to a tidy and order cell membrane, and the permeability of the cell membrane is further improved. The surfactant molecules contain liposoluble groups, so that the surfactant molecules can well react with the cell membrane.

The invention provides a defecation contrast agent and a preparation method thereof. The defecation contrast agent comprises the following components in parts by weight: 25 to 30% of II type barium sulfate, 1.5 to 2.5% of sodium hyaluronate, 1.5 to 2.5% of carbomer, 10 to 15% of bletilla striata powder, 0.1 to 0.2% of a humectant, 0.001% to 0.005% of essence and 55 to 60% of a solvent. The defecation contrast agent disclosed by the invention is stable in formula and can be used after being opened, so the use convenience and comfort of medical personnel and patients during defecation contrast examination are improved.

The invention discloses anti-wrinkle essence containing collagen. The anti-wrinkle essence is prepared from the following raw materials in parts by weight: 3 to 5 parts of xanthan gum, 5 to 8 parts of glycerol, 50 to 60 parts of deionized water, 2 to 5 parts of glyceryl stearate, 1 to 3 parts of squalane, 2 to 3 parts of collagen, 1 to 1.5 parts of capric triglyceride, 2 to 5 parts of butanediol, 1.5 to 2 parts of avocado ester, 0.5 to 1.5 parts of carbomer, 2 to 3 parts of humectant and 5 to 8 parts of anti-wrinkle micro-capsules, the anti-wrinkle microcapsule contains rich polyphenol substances, the molecular structure of a phenolic compound contains some phenolic hydroxyl groups capable of releasing hydrogen, and the hydrogen and free radicals are condensed together to terminate chain reaction caused by the free radicals, so that the anti-wrinkle microcapsule has high free radical scavenging capacity, the anti-oxidation effect of cells is better. The curcumin can well inhibit the activity of the white gelatinase, so that the anti-wrinkle effect of the essence is improved, and the effective time of the essence is prolonged.

The invention discloses an oral care composition and application. The oral care composition comprises 1) soluble zinc, 2) carbomer and 3) an orally acceptable carrier, wherein the detectable concentration of the soluble zinc in the oral care composition is larger than or equal to 45 ppm. According to the oral care composition, the concentration of soluble zinc in the composition can be retained, and meanwhile, the unpleasant astringent taste of the soluble zinc is reduced, so that on one hand, the antibacterial effect of the composition is better exerted, and on the other hand, the use of thecomposition is not limited by the taste; and the composition can also effectively prolong the retention time of zinc in the oral cavity.

The invention discloses an external-use drug and preparation with analgesic and antibacterial effect and a preparation method thereof. The external-use drug comprises a component A like silver sulfadiazine, a component B like zinc sulfadiazine and an analgesic component like lidocaine. Excipients of the preparation include Carbomer, glycerin, triethanolamine and water. The preparation method includes: adding water into Carbomer for swelling, and adding triethanolamine to adjust pH to obtain transparent colloid; adding glycerin dispersed with the components A and B into the transparent colloid to obtain milky colloid; using water to disperse and dissolve the analgesic component, adding into the milky colloid, using water to adjust water content, and stirring well. The external-used drug and preparation has the analgesic and antibacterial effect, wound healing time can be shortened remarkably, and the preparation method is simple, convenient, economical and wide in application prospect.