The invention discloses a preparation device of a medicine for treating liver and gallbladder diseases. The preparation device comprises a barrel body, supporting legs, a feeding cylinder, a surrounding plate, a crushing roller, a partition plate, a supporting plate, an output motor, an output gear, a grinding roller, an upper threaded groove, a lower threaded groove, a surrounding edge, a driving shaft, a rotating plate, a feeding opening, a limiting plate, a gear ring, an electric push rod, a grinding wheel, a sieve plate, a conveying motor, a connecting shaft, a cam, a groove, a storage groove, a fixed pipe, a control valve, a collecting groove, a filter screen, a sleeve, a connecting pipe, a connecting rod, an end socket, a sealing ring, a spring, conveying wheels and a conveying belt. The preparation device has the beneficial effects that the grinding roller and the grinding wheel are adopted to grind different kinds of medicine powder, the efficiency is high during grinding, the device has storage and screening functions, meanwhile, the device has a powder metering control function, simultaneous grinding and mixing proportioning of multiple kinds of medicine are achieved, blocking at a medicine powder outlet can be achieved, accurate control over the medicine is achieved, and the problem of inconsistent metering during medicine powder preparation can be solved.