107 results about "Methyl sulfones" patented technology

The invention discloses a mesosulfuron-methyl synthetic method. The mesosulfuron-methyl synthetic method is characterized in that mesosulfuron-methyl is prepared from raw materials such as paratoluic acid by adopting the seven steps of chlorosulfonation-ammonolysis, oxidation, dehydration, reduction, alcoholysis, methyl sulfone chloride acylation and condensation. The mesosulfuron-methyl synthetic method provided by the invention has the advantages of being low in cost of the raw materials, easy in availability of the raw materials, simple in operation and mild in conditions, having low requirements on equipment, high yield and strong practicability and being suitable for industrial production.

The invention provides a method for preparing (2S, 3R)-p-methyl sulfone phenyl ethyl serinate from the cheap and easily available methylsulfonyl benzaldehyde and L-threonine under the action of transaldolase. The amino acid intermediate then undergoes ethyl esterification to obtain a target product (2S, 3R)-p-methyl sulfone phenyl ethyl serinate.

The invention discloses a compound preparation method, which comprises the following steps: a) a compound disclosed in formula I and 4-chlorine-6-iodine-quinazoline are in backflow reaction in isopropanol; b) kieselguhr, stannous chloride, trifluoroacetic acid, H2PdCl4 and polyvinylpyrrolidone are mixed in water and heated to 100-150 DEG C, and a Pd catalyst is obtained after reaction; c) the products obtained in step a), the Pd catalyst, 5-formyl furanboronic acid and K2CO3 are mixed to be reacted in a first organic solvent; and d) reaction products obtained in step c), organic base and 2-(methyl sulfone) ethylamine hydrochloride are mixed in a second organic solvent, and lapatinib basic groups or analogues thereof are obtained after reaction. The heterogeneous Pd catalyst is adopted, and because the heterogeneous Pd catalyst is easy to recycle, the preparation method provided by the invention protects the environment at the time of saving raw materials. Formula (I) is disclosed in the specification.

The invention discloses a bone joint composite nutrient supplement and a preparation method thereof. The bone joint composite nutrient supplement comprises the following components in parts by weight: 350-600 parts of glucosamine hydrochloride, 350-450 parts of chondroitin / MSM (methyl sulfonyl methane) mixture and 16-60 parts of traditional Chinese medicine extract, wherein the chondroitin / MSM mixture comprises chondroitin sulfate, dimethyl sulfone, collagen, frankincense and hyaluronic acid according to weight part of 2:3:1:1:3, the extraction process of the traditional Chinese medicine extract comprises the steps of smashing clean traditional Chinese medicinal materials, heating and back flowing for 2-3 hours by a low solubility ethyl alcohol solution, extracting for 3 times, combining the extracting solutions, after purification, concentrating, and drying at low temperature. The bone joint composite nutrient supplement not only can improve various arthritis and symptoms caused by arthritis, but also can improve various symptoms caused by osteoporosis.

The invention relates to a preparation method of a florfenicol oxazoline intermediate, and belongs to the technical field of drug preparations. The preparation method of the florfenicol oxazoline intermediate as shown in a formula (I) comprises the following steps: using D-p-methyl sulfone phenyl ethyl serinate as a raw material, adding a reducing agent into an alcohol proton solution of organic alkali in one time, performing a reducing reaction to generate ADS (amino diol sulfone), and controlling a reaction endpoint by HPLC (high performance liquid chromatography); after the reducing reaction, concentrating a solvent; adding glycerin for destroying the excess reducing agent, adjusting the pH value to be 6-7 by acid, dropwise adding dichloroacetonitrile, heating to 50 DEG C, performing a cyclization reaction, and controlling a reaction endpoint by the HPLC; after the cyclization reaction, dropwise adding an ethanol water solution, conducting a centrifugal process, washing, and drying to obtain the florfenicol hydroxyl oxazoline intermediate as shown in the formula (I). According to the method, the reducing agent can be added in one time; meanwhile, the hydrogen release speed in the preparation process is very slow, so that the safety is greatly improved.

The invention relates to composition with effects of increasing bone mineral density, preventing inflammation and easing pain and a preparation method thereof. The composition with the effects of increasing bone mineral density, preventing inflammation and easing pain is prepared from the following bulk pharmaceutical chemicals ingredients of chondroitin sulfate, glucosamine hydrochloride, calcium carbonate, sodium hyaluronate, dimethyl sulfone and radix puerariae extract. The invention further relates to a film-coated tablet prepared from the composition and a preparation method of the film-coated tablet. The composition has a better curing effect of increasing bone mineral density, and all ingredients have a synergistic effect, can easily improve calcium absorption and can well increase bone mineral density; animal function experiments prove that the composition can obviously improve the thighbone weight, the bone calcium content, the thighbone middle point density and the thighbone telecentric end bone mineral density of a rat.

The invention discloses a healthcare agent for pet joints and belongs to the technical field of feed additives. The healthcare agent uses chondroitin sulfate, glucosamine hydrochloride, dimethyl sulfone and collagen as the core components and vitamins and mineral elements as the auxiliary materials and is applicable to pets with arthritis, caused by excessively fast growth and development or maldevelopment, movement damage, senile joint degeneration and the like, of different degrees. The healthcare agent can promote bone health, increase pet immunity, improve pet bone joint diseases and increase pet living quality.

The invention discloses a compound combined preparation for preventing osteoarticular pain and a preparation method thereof; the preparation comprises an active component glucosamine or combinations of more than one or two of the glucosamine and other active components chondroitin sulfate, dimethyl sulfoxide and collagen protein, and the glucosamine is glucosamine sulfate, hydrochloride, phosphate or the mixture thereof; and auxiliary materials comprise excipient, disintegration agent, lubricant, adhesive, stabilizer and wetting agent. The invention has good curing and preventing functions to injury in arthritis and joint movement, the prepared tablets have the advantages of good disintegration performance, high dissolution speed and quick effect, the used amount of the raw materials and all the auxiliary materials reaches the best ratio, the product stability is improved, and the absorption utilization rate is high.

The invention relates to a cooking auxiliary agent for papermaking and pulping, belongs to the field of papermaking, and aims to solve the problems that the existing cooking auxiliary agent is high in toxicity and severe in environmental pollution. The cooking auxiliary agent for papermaking and pulping comprises the following components in percentage by weight: 8-12% of primary alcobol ethoxylate, 10-20% of linear alkylbenzene sulfonates, 3-8% of alkyl sulfonate sodium acetate, 3-8% of alkyl phenyl polyoxyethylene ether, 2-5% of sodium nonylphenol polyoxyethylene ether sulfonate, 1-3% of methyl sulfone, 2-5% of carboxymethyl cellulose, 0.5-1.2% of oleamide, 0.1-0.5% of sodium pyrophosphate and the balance of deionized water. The cooking auxiliary agent is mainly applicable to the papermaking field, can reduce environmental pollution, improve the screened pulp yield and reduce Kappa number.

The present invention relates to a composition comprising an effective amount of diiodomethyl-p-tolylsulfone wherein the diiodomethyl-p-tolylsulfone is present as a particulate dispersion in a liquid solvent. In a further embodiment, the present invention relates to a composition wherein at least about 30% retained activity is achieved as the diiodomethyl-p-tolylsulfone is present as a particulate dispersion in a liquid solvent. In yet a further embodiment, the present invention relates to a composition wherein greater than 70% of the diiodomethyl-p-tolylsulfone remains in the form of a particulate dispersion in a liquid solvent.

The invention discloses a mutation and screening method for salt-tolerant buckwheat mutants. The method comprises the following steps: treating and mutating buckwheat seeds by adopting EMS (Ethyl Methyl Sulfone), screening buckwheat mutants insensitive to ethylene by virtue of a direct precursor ACC (1-aminocyclopropane-1-carboxylic acid) obtained through ethylene synthesis, cultivating the buckwheat mutants into saline-alkali soil with the salinity of 0.4 to 0.6 percent, screening salt-tolerant plants, planting harvested buckwheat seeds into the saline-alkali soil with the salinity of 0.4 to 0.6 percent, and further screening the salt-tolerant buckwheat mutants with stable characters. According to the mutation and screening method for the salt-tolerant buckwheat mutants, the mutants are easily obtained by mutation with the EMS, DNAs are less damaged by point mutation, and meanwhile, screening with the direct precursor ACC in combination with ETH is combined to screen the salt-tolerant buckwheat mutants, so that the mutation frequency is high, the target is clear, the screening efficiency is high, and can reach 10 to 20 percent, the operation cost is low, and the obtained mutants have stable characters.

The invention discloses a two-in-one filtering device comprising a washing kettle. The lower end of the washing kettle is fixedly connected with a plurality of support bases arranged in equal axial spacing. The lower end of the washing kettle is provided with a liquid outlet, and the inner bottom of the washing kettle is fixedly connected with support rods arranged in equal axial spacing; the upper ends of a plurality of support rods are jointly fixedly connected with a fixed plate, and the fixed plate is provided with a washing dehydration mechanism; the inner wall of the washing kettle is fixedly connected with two oppositely arranged heating plates, the inner wall of the washing kettle is fixedly connected with a temperature sensor, and the side wall of the washing kettle is fixedly connected with a temperature displayer. The structure is reasonable in design. Due to completely closed filtration and leak-free production, the industrial production method of p-methyl sulfone toluene can avoid harm to a human body and environment, no any environmental pollution exists, continuous production can be achieved and the production efficiency is improved, so that the production needs of enterprises can be met.

Sulfone is an important drug and bioactive compound. Sulfone is widely used as a medicament, such as a medicament gamma-secretase inhibitor for preventing Alzheimer's disease, and is widely applied tobioactive compounds, natural products and agricultural chemicals, such as currently popular herbicide mesotrione. Sulfone is also most often used as an intermediate for organic synthesis. On the other hand, a chalcogen heterocyclic stent has biological activity, such as antitumor drugs and antiproliferative drugs. As is well-known, thiophene, furan and selenium compounds have a variety of biological activities, such as anti-inflammatory agents, anti-HIV PR inhibitors, NQO2 inhibitors, and anticancer agents. The invention develops a simple, convenient and efficient Bronsted acid, i.e., sulfuric acid and catalyzed three components react in water to synthesize aryl(chalcogen-heteroaryl)methyl sulfone, the yield is good to be very high, and the substrate range is wide. The synthesis method isenvironment-friendly and economic, and does not need metal catalysis. The sulfone product can be effectively converted into bactericide analogues and aryl heteroaryl ketones.

The invention belongs to the field of organic synthetic chemistry, and in particular relates to a preparation method of dimethyl sulfone as well as used catalyst and catalyst composition thereof. The general formula of the catalyst is aFe2O3.bMnO2.cTiO2.dRh203.eRuO2, wherein a, b and c are selected from 0 to 15 independently, and d and e are selected from 0.01 to 10 independently. The catalyst composition comprises the catalyst and photosensitizer with the mass ratio of 1:0.01 to 10. The catalyst / catalyst composition has efficient catalytic activity, oxygen is taken as single oxidant during a process of catalyzing dimethylsulfide or dimethyl sulfoxide to prepare dimethyl sulfone, and compared with a conventional nitric acid technique and a potassium permanganate method, the preparation method has the advantages that during preparation, any hazardous substances can not be caused, and pollution is not caused to the environment.

The invention relates to a method for preparing a safe and effective antibechic dimimorfan phosphate. The method comprises steps of reacting dextrorphane with trifluoro-methylsulfonyl chloride in triethylamine so as to generate dextrorphane trifluoro-methyl sulfone chloride ester; reacting the dextrorphane trifluoro-methyl sulfone chloride ester with tetramethyltin in methylbenzene so as to generate (9s, 13s, 14s)-3, 17-dimethyl morphinan (or adding the dextrorphane trifluoro-methyl sulfone chloride ester into mixed solvent of THF and N-methyl-2-pyrrolidone, adding catalyst ferric acetylacetonate and methyl magnesium bromide, stirring and heating reflux for 12 hours, so as to prepare (9s, 13s, 14s)-3, 17-dimethyl morphinan), furthermore, reacting with phosphoric acid so as to salify to prepare target product (9s, 13s, 14s)-3, 17-dimethyl morphine phosphate-dimimorfan phosphate. The method takes commercially available dextrorphane as the raw material, and prepares the target product through three steps of esterification, methylation and salification. The method has advantages of easily obtained raw materials, few synthesis steps, simple technology, low cost, high yield, high purity of the product and strong economic practicability, and is applicable to industrial production.

The invention discloses a synthesis process for DL-p-methyl sulfone benzene ethyl serinate water-carrying esterification. The synthesis process comprises the following steps: (1) putting a copper saltand absolute ethyl alcohol into a reactor, dropping sulfuric acid to carry out an esterification reaction, and after the reaction is completed, filtering so as to obtain esterification filtrate; (2)heating the esterification filtrate obtained in the step (1), concentrating, performing water-carrying esterification with the absolute ethyl alcohol, and after the water-carrying esterification is completed, performing aftertreatment, thereby obtaining DL-p-methyl sulfone benzene ethyl serinate. The synthesis process is simple in reaction route, high in product yield, good in synthesis product stability and high in purity, and can be adopted to synthesize a key intermediate of a veterinary drug florfenicol and an antibacterial raw material medicine thiamphenicol.

The invention discloses a method for synthesizing (1R, 2R)-1-p-methyl sulfone phenyl-2-amino-1,3-propanediol, which belongs to the technical field of chemical medicines. The method comprises the following steps: 1. carrying out condensation on p-methylsulphonyl benzaldehyde (II) and primary amine so as to obtain a compound (III); 2. in the presence of a catalyst, carrying out acridine reaction on the compound (III) and ethyl diazoacetate so as to obtain a compound (IV); 3. carrying out reduction on the compound (IV) so as to obtain a compound (V); and 4. in the presence of an acid, carrying out ring-opening reaction and de-protection reaction on the compound (V) by a one-pot method so as to obtain the (1R, 2R)-1-p-methyl sulfone phenyl-2-amino-1, 3-propanediol. The method provided by the invention has the advantages of novel design, simple and short route, mild conditions, good enantioselectivity, high yield, and good industrialized production prospect, and is simple and convenient in operation.

The invention provides a manufacturing method of antibacterial fiber filament. The manufacturing method comprises the following steps: mixing p-[(diiodomethyl)sulphonyl]toluene and plastic master batch so as to combine the plastic master batch with the p-[(diiodomethyl)sulphonyl]toluene, and then melting and spinning the mixture so as to obtain the antibacterial fiber filaments.

The embodiment of the invention discloses a composition, a preparation method and an application of the composition in preparation of medicines, health-care products and foods for treating pet joint diseases. The composition comprises glucosamine, chondroitin sulfate, dimethyl sulfone, green mussels, haematococcus pluvialis, frankincense, curcumin, coix seeds and rhizoma smilacis glabrae. The composition fundamentally inhibits and relieves arthritis from the aspects of eliminating free radicals, neutralizing free radicals, inhibiting proinflammatory cell generation and the like, supplements necessary nutrient substances for cartilage cell growth, promotes synthesis of new cartilage, and achieves the effect of treating both symptoms and root causes in combination with traditional Chinese medicine components for rapid detumescence and pain relief.

The invention discloses a method for synthesizing methyl sulfone base dibromo toluene. The method comprises the following steps of enabling methyl p-tolyl sulfone and bromine to perform thermal reaction for 5-20 hours at the temperature of 50-200 DEG C under the effect of an catalytic agent to obtain liquid crude product methyl sulfone base dibromo toluene, wherein the mole ratio of the methyl p-tolyl sulfone to the bromine is 1: (1-10); and separating the liquid crude product methyl sulfone base dibromo toluene to remove hydrobromic acid produced in the reaction and unreacted bromine to obtain granular solid crude product methyl sulfone base dibromo toluene. The method is short in process flow and mild in reaction condition, the reaction can be easily controlled, industrial production can be easily achieved, no solvent is used, the whole reaction process is free of pollution and emission, and the product yield is as high as 93-98%.

The invention discloses a fungicidal composition containing 2-methyl sulfone-5-(2,4-dichlorophenyl)-1,2,3-oxadiazole and fluopicolide and application of the fungicidal composition. The active ingredients comprise 2-methyl sulfone-5-(2,4-dichlorophenyl)-1,2,3-oxadiazole and fluopicolide, the compound weight ratio of 2-methyl sulfone-5-(2,4-dichlorophenyl)-1,2,3-oxadiazole to fluopicolide is 1:30-30:1, and preferred weight ratio is 1:20-10:1. The fungicidal composition can be prepared into emulsifiable concentrate, wettable powder, oil-dispersible suspending agent, suspending agent, water dispersible granule, aqueous emulsion, microemulsion and granules. The fungicidal composition is reasonable in composition and good in fungicidal effect, and can achieve an obvious synergistic effect within the proportion range. The fungicidal composition has remarkable control effects on potato late blight and other various crop diseases.

Electrolyte formulations including a high salt concentration. The electrolyte formulation includes an organic solvent and a lithium salt, wherein the lithium salt is mixed with the organic solvent at a concentration of at least 20 Mole %, or at least 40 Mole %, or at least 50 Mole %. The organic solvent includes N-methyl-2-pyrrolidone, butylene carbonate, butyl propionate, pentyl acetate, γ-caprolactone, propylene glycol sulfite, ethyl methyl sulfone, butyl sulfoxide or combinations thereof. The lithium salt includes lithium bis(trifluoromethane sulfonyl) imide, lithium tetrafluoroborate, or lithium hexafluorophosphate.

PCT No. PCT / EP95 / 03567 Sec. 371 Date Mar. 3, 1998 Sec. 102(e) Date Mar. 3, 1998 PCT Filed Sep. 11, 1995 PCT Pub. No. WO97 / 10270 PCT Pub. Date Mar. 20, 1997New betaketosulfonic derivatives, the process for their preparation, the photopolymerizable systems containing the same and their application as polymerization photoinitiators for inks, and particularly for inks having high content of pigments are described.

The invention discloses a method for preparing tembotrions, and belongs to the technical field of organic chemical industry. The method comprises the steps that sodium 2,2,2-trifluoroethanolate and 2-chloro-3-brooethyl-4-methylsulfonylpropyl methyl benzoate react, and generated 2-chloro-3-trifluoro-ethoxy methyl-4-methyl sulfone chloride benzoic acid and 1,3-cyclohexanedione are condensed and rearranged to prepare tembotrions. According to the method for preparing tembotrions, the defects that in a traditional method, 2-chloro-3-brooethyl-4-methyl sulfone chloride methyl benzoate, trifluoroethanol and potassium tert-butoxide are used for preparing 2-chloro-3-trifluoro-ethoxy methyl-4-methyl sulfone chloride benzoic acid, the yield is low, and a potassium tert-butoxide reagent is expensive are overcome, meanwhile, the defect that after carboxyl is acylate chlorinated into ester, a toxic catalyst acetone cyanohydrins is needed in a rearrangement method is overcome, the advantages of being high in yield, low in cost, easy to operate, low in pollution, safe, environmentally friendly and the like are achieved, and the method is suitable for large-scale industrial production.

The invention discloses a preparation method of a florfenicol intermediate. The preparation method includes subjecting D-(-)-threo-[para-(methyl sulfone)phenyl]serine ethyl esters to redox reaction ina solution containing acridine salt photocatalysts and reductants to generate the florfenicol intermediate. The preparation method of the florfenicol intermediate has the advantages that acridine salt serves as the photocatalysts, and carbonyl in the D-(-)-threo-[para-(methyl sulfone)phenyl]serine ethyl esters is reduced into hydroxyl with the presence of the reductants, so that side products arereduced effectively, yield of target products is increased, and synthesis cost is reduced.

The invention discloses a preparation method of a 2-(amino)ethyl methyl sulfone salt represented by formula 1. The preparation method comprises: (1) in an organic solvent and under the action of a substitution reaction catalyst, a compound 3 is reacted with a compound 4; and X is a halogen, and M is an alkali metal or an alkaline earth metal; and (2) a compound 2 prepared by the step (1) is reacted with an acidic aqueous solution to obtain a compound 1; n is equal to 1 or 2; m is equal to 1 or 2; and HmA is an organic acid or an inorganic acid. The invention also discloses a preparation method of the compound 2. The preparation method of the compound 2 comprises: 1) in an organic solvent and under the action of an alkali, a compound 5 is reacted with a halogenation reagent; and 2) in the organic solvent, under the action of the substitution reaction catalyst, the compound 4 is reacted with the compound 3 prepared by the step 1), X is a halogen, and M is an alkali metal or an alkaline earth metal. The preparation methods have low cost and easy availability of raw materials, have no environmental pollution factors, and are suitable for industrial mass production.

The invention relates to a new 2-indolinone compound and a preparation method and the usage to prepare the compounds. The general formula of the new derivatives of indolinone provided by the invention is the formula above, when in preparation, the 3-position and the 5-position of 2-indolinone are respectively introduced by amide and a carboxamide methyl sulfonyl structure to get the new derivatives. The 2-indolinone compounds of the invention have good activity of inhibition of tumor cell growth.

The invention discloses a preparation method of p-methyl sulfone phenyl ethyl serinate and belongs to the technical field of a synthetic technology of veterinary drugs and pharmaceutical intermediates. According to the technical scheme, the preparation method is characterized in that p-methyl sulfone phenyl serine copper is dissolved in a sodium hydroxide solution, an Na2S solution is added to precipitate Cu<2+>, activated carbon is added to adsorb excess S<2->, the mixture is mechanically agitated and subjected to suction filtration, hydrochloric acid is added to a filtrate to regulate pH to be 3-7, and the mixture is subjected to condensation crystallization and suction filtration to obtain p-methyl sulfone phenyl serine; the p-methyl sulfone phenyl serine is dissolved in absolute ethyl alcohol, concentrated sulfuric acid is added, the mixture is subjected to reflux for 4 h, cooling crystallization and suction filtration, a filter cake is dissolved in water, a saturated Na2CO3 solution is added to regulate pH to be neutral, and the p-methyl sulfone phenyl ethyl serinate is obtained after suction filtration. The preparation method has the advantages as follows: the Na2S solution is added in an alkaline environment to remove Cu ions, the excess S<2-> is removed through activated carbon adsorption, and production of toxic and irritant gas H2S through combination of S ions and H ions is avoided, so that the problem of environmental pollution is solved effectively.