24 results about "Methyl sulfones" patented technology

The invention belongs to the technical field of organic radiation luminescence and radiation imaging, and discloses an aggregation-induced delayed fluorescence (AIDF) type organic scintillator material and a preparation method thereof, and a preparation method and application of a flexible organic scintillation film. The molecular structure of the material comprises carbonyl, methylene, sulfuryl and other connecting units, phthalonitrile is used as an acceptor unit, carbazole is used as a donor unit, an aggregation-induced excitation state is formed through space charge transfer among molecules, efficient AIDF luminescence and large Stokes shift characteristics are realized, the self-absorption phenomenon is effectively avoided, and the luminescent efficiency is improved. The X-ray fluorescence probe is suitable for a luminescence process under an X-ray excitation condition, the sensitivity of X-ray detection is remarkably improved, and the lowest detection limit can reach 276nGy.s <-1 > and is far superior to the 5.5 mu Gy.s <-1 > standard required by medical diagnosis. Besides, the flexible scintillator film prepared based on the material system radiates and emits light within the waveband range of 450-750 nm and is perfectly matched with the response area of a silicon-based detector, X-ray imaging with the high signal-to-noise ratio is achieved, and the imaging resolution is as high as 20.01 lp.mm <-1 >.

The object of this invention is a lipophilic activity modifier in the form of dimethyl sulfone (MSM) for use as a transdermal penetration enhancer for high molecular weight active substances with a molecular weight (Mw) > 500 Da. Another object of this invention is a cosmetic composition for transdermal application comprising an active substance and a transdermal penetration enhancer, characterized in that the active substance is encapsulated by the transdermal penetration enhancer, which is the lipophilic activity modifier according to claim 1, and the active substance is a high molecular weight active substance with a molecular weight (Mw) > 500 Da. Another object of the present invention is a method for preparing a composition according to the invention, characterized in that the method is carried out by thermal emulsification or cold emulsification, wherein thermal emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel; b) bringing the mixture to 70-85°C; c) stirring the mixture at 70-85°C; the start of homogenization depends on the stage of phase combination; d) cooling the mixture to 20-40°C, preferably 30°C; e) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min; while cold emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel and dissolving at a temperature maintained at 20-25°C; b) bringing the mixture to a temperature of 15-35°C, preferably ambient temperature or 25°C; c) stirring the mixture at a temperature of 15-80°C, preferably 25°C; the start of homogenization depends on the stage of phase combination; d) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min.

The present invention provides novel 4-methylsulfone-substituted piperidine / urea compounds useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and / or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds, as well as methods for the treatment of DCM and other forms of heart disease, are described.

The present application relates to a kind of substituted p-methyl sulfone aniline derivatives and its preparation method and application, belong to the technical field of drug synthesis. Specifically, the present application discloses a kind of substituted p-methyl sulfone aniline derivatives shown in general formula (I) and the application of pharmaceutical composition containing the derivative in the preparation of antiparasitic drugs.The structure general formula (I) of the substituted p-methyl sulfone aniline derivative is as follows:(I);The effect of the substituted p-methyl sulfone aniline derivative of the present application in the prevention and treatment of parasitic infection, vector insects, forest pests, etc., has broad application prospects.

The application discloses a multi-component synovitis treatment composition based on repairing cartilage tissue and application thereof, and relates to the technical field of biological medicine, and the composition is composed of glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone and graded molecular weight sodium hyaluronate; the application precisely compounding the graded molecular weight sodium hyaluronate with the glucosamine hydrochloride, the chondroitin sulfate and the dimethyl sulfone according to weight parts, constructs a gradient slow-release and target delivery system of synovitis lesions, specifically inhibits the activity of hyaluronidase in the inflammatory joint cavity by using the dimethyl sulfone, greatly reduces the degradation of the sodium hyaluronate, prolongs the residence time of the active ingredients at the lesion site, realizes immediate analgesia and relieves joint stiffness by quickly forming a lubricating protective film by the high molecular weight sodium hyaluronate, the medium and low molecular weight sodium hyaluronate penetrates the synovial membrane barrier and carries the cartilage repair components to enrich in the cartilage defect area, and the synergistic effect of the components is realized.

The invention relates to a compound turpentine liniment as well as a preparation method and application of the compound turpentine liniment. Comprising the following preparation raw materials in percentage by mass: 8 to 12 percent of turpentine, 45 to 55 percent of glycerol, 12 to 18 percent of cyperus esculentus extract, 5 to 10 percent of soft soap, 0.5 to 1.5 percent of camphor, 0.1 to 1 percent of glucosamine, 0.5 to 2 percent of chondroitin sulfate, 0.1 to 1 percent of dimethyl sulfone, 0.5 to 2.5 percent of oil-soluble azone, 0.1 to 1 percent of lauramide propyl amine oxide and 12 to 20 percent of purified water. The cyperus esculentus extract prepared by the preparation method disclosed by the invention is compounded with the turpentine for use, a certain synergistic effect exists between the cyperus esculentus extract and the turpentine, the effect of reducing inflammatory factors in serum of the compound turpentine liniment can be improved, and the high-temperature-resistant stability is good; the compound turpentine liniment has an obvious better effect on reducing inflammatory factors in serum, so that a synergistic effect possibly exists between cellulase and mannase, and the compound turpentine liniment has a better curative effect on arthritis.

The invention provides a construction method of a light-stable high-photon-number fluorescent probe and application of the light-stable high-photon-number fluorescent probe in single-molecule and super-resolution fluorescence imaging. The probe is efficiently prepared through one-pot multi-component reaction of aldehyde containing cyclooctatetraene, amine containing benzothiazole methyl sulfone, fluorophore carboxylic acid with a click tag and tert-butyl isocyanide. The probe can realize cysteine site specific labeling through nucleophilic aromatic substitution, the cyclooctadiene light stabilizer can effectively quench triplet, photon output and photobleaching resistance are improved synergistically, and the probe and the cyclooctadiene light stabilizer are suitable for super-resolution fluorescence imaging of biomacromolecules such as single molecules and nucleopore proteins. And a high-performance probe is provided for an advanced super-resolution fluorescence microscopy technology.

The present application relates to the field of agricultural technology, in particular to a plant temperature-sensitive male sterility gene mutant tms17 and application thereof.The nucleotide sequence of the plant temperature-sensitive male sterility gene mutant tms17 comprises the nucleotide sequence shown in SEQ ID NO.1 in the sequence listing.The present application screens a new temperature-sensitive male sterile line tms17 by chemical mutagen ethyl methyl sulfone (EMS) mutagenesis of japonica rice variety ZH11, which is completely sterile at high temperature and fertility is restored at low temperature, and the mechanism of temperature-sensitive fertility restoration is disclosed, which provides a new germplasm resource with application potential for rice two-line hybrid breeding.

Describe herein a nutraceutical composition containing synergistic combination of Hyaluronic acid, Dimethyl sulfone and / or zinc. Further, the invention provides a process for manufacturing the said synergistic composition.

The invention relates to a substituted p-methylsulfone aniline derivative as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. Specifically, the invention discloses a substituted p-methylsulfone aniline derivative as shown in a general formula (I), a pharmaceutical composition containing the derivative and application of the derivative in preparation of anti-parasitic drugs. The structural general formula (I) of the substituted p-methylsulfone aniline derivative is shown in the specification, the substituted p-methyl sulfone aniline derivative has a remarkable effect on preventing and treating infection of parasites, vector insects, agricultural and forestry pests and the like, and has a wide application prospect.

The invention belongs to the field of electrochemical energy, and particularly relates to a sodium ion battery electrolyte and a sodium ion soft package battery thereof. The sodium-ion battery electrolyte is mainly composed of a sodium salt, a sulfone organic solvent, a dilution additive and a film-forming additive, wherein the sulfone organic solvent comprises sulfolane, 3-methyl sulfolane, dimethyl sulfone, ethyl methyl sulfone and fluoro sulfolane; the diluting additive is prepared from perfluorotributylamine, 3-perhexafluoro-1, 2-epoxypropane, 3-perfluorooctyl-1, 2-epoxypropane, 3-perfluorodecyl-1, 2-epoxypropane, 1, 1, 2, 2-tetrafluoroethyl-2, 2, 2-trifluoroethyl ether, and 1, 1, 2, 2-tetrafluoroethyl-2, 2, 3, 3-tetrafluoropropyl ether, and the diluting additive is prepared from perfluorotributylamine, 3-perhexafluoro-1, 2-epoxypropane, 3-perfluorooctyl-1, 2-epoxypropane, 3-perfluorooctyl-1, 2-epoxypropane, 3-perfluorooctyl-1, 2-epoxypropane, 3-perfluorodecyl-1, 2-epoxypropane, 1, 1, 2, 2-tetrafluoroethyl-2, 2 Compared with the traditional carbonic ester electrolyte, the sulfone solvent has a wide voltage window, can improve the energy density of the sodion soft package battery, and has higher viscosity when being independently used. The diluting additive can reduce the viscosity of the sulfone solvent to 0.6-1.2 mPa.s, which is close to the viscosity of a chain carbonate solvent, so that the dissolution of the sodium salt in the solvent is promoted, and the sulfone solvent is well applied.

The invention provides a method for determining oxyfenthion, oxyfenthion sulfone and oxyfenthion sulfoxide in fruits and vegetables. The method comprises the following steps: sampling; the pretreatment comprises the following steps: adding a 1% glacial acetic acid solution into the to-be-detected sample, and carrying out vortex standing; then adding acetonitrile and an internal standard solution, and carrying out vortex oscillation to obtain a dissolved solution; adding mixed powder of anhydrous magnesium sulfate and buffer salt, immediately shaking and dispersing, and sequentially carrying out oscillation, ice bath and centrifugal treatment; taking the primary supernate, putting the primary supernate into a dispersive solid-phase extraction purification tube filled with a purification material, and sequentially carrying out vortex treatment, oscillation treatment and centrifugal treatment; taking the second supernatant, and performing water bath nitrogen blowing concentration to obtain a redissolved sample; then adding acetonitrile into the redissolved sample to a constant volume, uniformly mixing and filtering to obtain an on-machine test solution; and putting the loading test solution into a high performance liquid chromatography tandem mass spectrometer for qualitative and quantitative detection and analysis. According to the method, the content of oxyfenthion, oxyfenthion sulfone and oxyfenthion sulfoxide in fruits and vegetables can be accurately measured, and the blank of national standard methods is filled.

The application discloses a feed additive for reducing the occurrence rate of watermarked eggs and a preparation method and application thereof. The formula of the feed additive is as follows: dimethyl sulfone 3.5-7.0 parts, yeast selenium 0.25-0.5 parts and corn flour 12.5-16.25 parts. 4 / 5 of the corn flour in the formula is added into a mixing machine, then the dimethyl sulfone is added, mixed for 3-5 minutes, the yeast selenium is added, and the mixing is continued for 3-5 minutes, finally the remaining 1 / 5 of the corn flour is added, and the mixing is continued for 3-5 minutes, so the feed additive for reducing the occurrence rate of watermarked eggs is obtained. The feed additive is added into the egg chicken feed at a proportion of 0.2%, and can be used for reducing the occurrence rate of watermarked eggs after 14 days of continuous feeding. The feed additive for reducing the occurrence rate of watermarked eggs can significantly improve the watermarked egg problem, and brings significant improvement to the economic benefits of the egg chicken breeders.

The invention belongs to the technical field of animal foods, and relates to a nutritional food for improving joint health of pets and a preparation method thereof. The nutritional food comprises the following raw materials: sweet potato powder, chicken powder, enzymolysis chicken, chicken oil, grains, beef powder, starch, fruit and vegetable powder, chicken liver powder, whole goat milk powder, fish oil, linseed oil, yolk powder, vitamin E, sodium hyaluronate, bovine bone collagen peptide, glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone, a vitamin mineral premix and a Chinese herbal medicine premix. The nutritional food for improving joint health of pets provided by the invention is rich in nutrition, good in palatability and simple in production process, does not lose nutrition of the raw materials, and promotes and improves digestibility of the nutritional food. Animal experiments show that the nutritional food for improving the joint health of the pets has the advantages that the Lequesne score of canine arthritis is reduced, the levels of IL-1beta and TNF-alpha in canine serum are reduced, the level of CTXII in the canine serum is reduced, and the canine osteoarthritis is effectively prevented and treated.

The invention relates to a solid dispersion containing dimethyl sulfone and application thereof, the solid dispersion contains a dispersing agent dimethyl sulfone and at least one medicine, and preferably, the solid dispersion is substantially composed of the dispersing agent dimethyl sulfone and at least one medicine. The preparation method comprises the following four methods: the first method comprises the following steps: uniformly dispersing dimethyl sulfone in a molten clarified state and a medicine to obtain a dispersion system in a molten state; and cooling the dispersion system in the molten state to obtain the solid dispersion. A second method comprises the following steps: uniformly dispersing dimethyl sulfone in a molten clarified state, a third solvent mixture and a medicine to obtain a molten dispersion system; and cooling the dispersion system in the molten state, and removing the third solvent to obtain the solid dispersion, and the third method comprises the following steps: extruding or grinding dimethyl sulfone and the medicine, stirring, melting, mixing and cooling. A fourth method comprises the following steps: preparing a molten mixture of dimethyl sulfone and a high-molecular polymer, adding the medicine when the molten mixture is in a molten state, and uniformly dispersing. The solid dispersion can be used for preparing a pharmaceutical preparation.

The invention discloses a functional polyimide yarn and a preparation method thereof, and relates to the field of fibers. When the functional polyimide yarn is prepared, amino-terminated hydrogen-containing silicone oil firstly reacts with 1-(3-allyl-2, 4-dihydroxyphenyl) ethanone, then reacts with 4, 4 '-oxydiphenylamine and 4, 4'-oxydiphthalic anhydride, is spun, and finally reacts with 4-pyridine methylsulfonyl chloride to prepare modified polyimide fibers; the preparation method comprises the following steps: carrying out surface treatment on yakwool, and then reacting the yakwool with 2-(diphenylphosphino) ethylamine, 2-bromo-1-[3, 5-di (tert-butyl)-4-hydroxyphenyl] ethanone and 4-(2-aminoethyl) pyridine in sequence to prepare modified yakwool; the modified polyimide fibers and the modified yakwool are subjected to surface treatment through a zinc acetate solution and then blended, and the functional polyimide yarn is prepared. The functional polyimide yarn prepared by the invention has good antibacterial and durable capabilities.

The invention discloses a synthetic method of a methyl sulfone compound, which comprises the following steps: by taking aryl sulfonyl chloride as a raw material, sequentially carrying out reduction reaction, nucleophilic substitution and decarboxylation reaction in a water phase, and finally separating and purifying to obtain the methyl sulfone compound. Aryl sulfonyl chloride is used as a raw material, reduction, nucleophilic substitution and decarboxylation reactions are continuously performed in a water phase through a one-pot method, separation of an intermediate product is not needed, operation is easy and convenient, reaction conditions are mild, use of an organic solvent is reduced to the maximum extent, the technology is green and environmentally friendly, and the obtained product is weak in water phase solubility and can be crystallized and separated out; the target product can be effectively separated through simple suction filtration, the separation effect is good, and the obtained target product is high in purity and ideal in yield.

The invention discloses an aqueous static zinc-air battery electrolyte and a preparation method and application thereof. The aqueous static zinc-air battery electrolyte comprises an organic compound, an electrolyte salt and an aqueous solvent, the organic compound is selected from one or more of dimethyl sulfoxide, dimethyl sulfone, diethyl sulfoxide, diethyl sulfone, cyclobutyl sulfoxide, cyclobutyl sulfone and dibutyl sulfoxide. The aqueous static zinc-air battery electrolyte provided by the invention is modified by introducing an organic compound with a relatively low price, and the organic compound can participate in a battery positive electrode reaction and change a traditional reaction path of the battery positive electrode reaction; compared with the traditional alkaline electrolyte, the aqueous static zinc-air battery electrolyte provided by the invention can reduce the charging potential of the battery and maintain the discharging potential of the battery, so that the charging and discharging potential difference of the battery is reduced, the utilization rate of a zinc negative electrode is improved, the energy efficiency of the battery can be effectively improved, and the aqueous static zinc-air battery electrolyte has a good application prospect.

The present invention discloses a multi-component synovitis therapeutic composition based on cartilage tissue repair and a use thereof, relating to the technical field of biomedicine. The composition comprises glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone, and graded molecular weight sodium hyaluronate. By compounding these components in precise parts by weight, the present invention constructs a gradient sustained-release and targeted delivery system for synovitis lesions. Dimethyl sulfone specifically inhibits hyaluronidase activity in the inflamed joint cavity, significantly reducing sodium hyaluronate degradation and prolonging the retention time of each active ingredient at the lesion site. High molecular weight sodium hyaluronate rapidly forms a lubricating protective film to achieve immediate analgesia and relieve ankylosis, while medium- and low-molecular-weight sodium hyaluronate penetrates the synovial barrier and carries cartilage repair components to the cartilage defect area, thereby achieving synergistic enhancement and comprehensively improving synovitis treatment efficacy.

The present invention provides novel piperidine urea compounds substituted with 4-methylsulfone, useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with systolic dysfunction or systolic reserve of the left and / or right ventricle. The synthesis and characterization of the compounds are described, as well as methods for the treatment of DCM and other heart diseases.

This invention belongs to the field of optoelectronic material preparation and application, and discloses a class of bifunctional phosphonic acid self-assembled molecules, their preparation and application. The self-assembled molecule has a structure as shown in one of general formulas A-1 to A-4, wherein the R1 and R2 groups are independently selected from groups containing lone pairs of electrons. This invention modifies the molecular structure by introducing groups R1 and R2 (e.g., benzaldehyde, methyl sulfone, benzyl oxy) containing lone pairs of electrons to form new self-assembled molecules while retaining the phosphonic acid groups. The resulting phosphonic acid self-assembled molecules possess both hole carrier transport function and perovskite interface defect passivation function, exhibiting bifunctionality.

The application belongs to the technical field of synthetic chemistry, and relates to an arylmethyl sulfone compound and a synthesis method thereof. The application takes an imidazopyridine compound as a reaction substrate, takes sodium sulfinate as a sulfone reagent, takes DMA as a methylene source, and directly obtains the arylmethyl sulfone compound through one-step reaction under the action of a catalyst and an oxidant. The synthesis method has the advantages of rapid reaction, low cost of raw materials, simple operation and high yield. The arylmethyl sulfone compound constructed by the application is an important skeleton of many drugs, bioactive molecules and natural products, and the synthesis method provides a widely applicable preparation method for the synthesis of the compounds.

The application discloses a method for synthesizing florfenicol through chemical enzyme coupling, and takes sodium beta-fluoro pyruvic acid salt, p-methyl sulfone benzaldehyde and D-alanine as substrates, under the cascade catalysis of pyruvate decarboxylase and transaminase, florfenicol amine is synthesized through a one-pot method, and florfenicol is synthesized through an amidation reaction. The synthesis route comprises the following steps: under the catalysis of pyruvate decarboxylase, the sodium beta-fluoro pyruvic acid salt and the p-methyl sulfone benzaldehyde are reacted to generate (1R)-3-fluoro-1-hydroxy-1-p-methyl sulfone phenyl-2-propanone; (1R)-3-fluoro-1-hydroxy-1-p-methyl sulfone phenyl-2-propanone and D-alanine are continuously converted into florfenicol amine by the transaminase in the reaction system, and finally, the florfenicol amine is subjected to a one-step chemical amidation reaction to synthesize florfenicol. Compared with the traditional chemical synthesis method of florfenicol, the method has fewer steps, and the steps related to configuration are replaced by high-stereoselective enzyme catalysis, so that the splitting step is saved, the reaction process is more green and environmentally friendly, the atom economy is higher, and the method is suitable for promotion and application.

The purpose of the present invention is to provide a composition that has a favorable flavor that is unique to mustard seeds, such as sweetness, and that has suppressed pungency. Firstly, the present invention relates to a method for producing an oil-based paste-like composition containing pulverized mustard seeds, the method comprising a step of pulverizing the mustard seeds in a mixture of mustard seeds and an oil or fat. Secondly, the present invention relates to an oil-based paste-like composition containing pulverized mustard seeds in which the content of allyl isothiocyanate is significantly lower than that of untreated mustard seeds, and the content of one or more of 2-methyltetrahydrofuran-3-one, 2-furfurylthiol, α-angelica lactone, 2-methyltetrahydrothiophen-3-one, tetrahydrothiophen-3-one, β-angelica lactone, γ-crotonolactone, dimethyl sulfone, furfuryl methyl sulfide, 1-furfuryl pyrrole, and guaiacol is remarkably higher than that of untreated mustard seeds.