The invention relates to a self-centering unmanned ship suitable for adverse sea conditions and a self-centering work manner of the self-centering unmanned ship, and belongs to the field of unmanned ship equipment and techniques. The unmanned ship comprises a main hull, a self-centering deck, equipment, a pipeline mast, a propeller, a radar, an air intake and exhaust system and a host machine system. According to the self-centering unmanned ship disclosed by the invention, the water-tight deck is designed, so that the hull of the unmanned ship has a self-centering function, the possibility of ship overturning of the unmanned ship is avoided, and additionally allocating self-centering equipment is not needed; besides, through the inner structure of the unmanned ship and the self-centering working manner, when a heeling angle of the hull exceeds a certain angle, a host machine and the air intake and exhaust system can be automatically turned off, so that the purpose that the whole ship is in a water-tight condition is realized; and when the heeling angle of the hull is returned to a small angle, the air intake and exhaust system and the host machine are automatically turned on, the mechanism is easy to operate, and the purpose of protecting a propelling system can be realized. During high-speed sailing in deep high sea, the unmanned ship can effectively and continuously work, and the unmanned ship is a reliable, economical and high-efficiency unmanned ship.