This invention belongs to the field of
contact lens technology, and provides a moisturizing
protein-based
contact lens and its preparation method. The preparation method includes the following steps: mixing a silk
fibroin solution and a
hyaluronic acid-
binding protein solution to obtain a
protein mixture solution; mixing a hydrophilic modification component, an
oxygen-permeable modification component, and water to obtain a composite modifier; mixing the
protein mixture solution, the composite modifier, and a crosslinking agent to obtain a pre-crosslinked mixture; molding the pre-crosslinked mixture and performing gradient crosslinking, followed by sequential soaking in
buffer solution, rinsing, and sterilization to obtain the moisturizing protein-based
contact lens. The contact lens of this invention uses protein as the main component, does not rely on
silicon-based substances or harmful crosslinking agents, and possesses high
biocompatibility,
high oxygen permeability, suitable mechanical properties, and controllable degradation.