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The invention relates to a preparation method of a magnesium alloy stent composite coating, and belongs to the technical field of biomedical materials. The composite coating with the piezoelectric-pH synergistic protection function is provided for solving the technical problems that an existing polyester coating is degraded to produce acid, and corrosion of a magnesium alloy stent is accelerated. The coating comprises a PVDF (Polyvinylidene Fluoride)-g-APTES ( The pH regulation and control middle layer is composed of PVDF, PDLLA and alkaline nanoparticles; and a drug-loaded PDLLA outer coating layer. The pH value of the interface is actively increased to a passivation region through on-demand release of the alkaline nanoparticles, and a positive feedback mechanism that protection is achieved when stress is increased is achieved through the piezoelectric effect. Compared with the prior art, the dynamic corrosion resistance is enhanced by 40% or above, the protection effect is improved by 60% or above through the synergistic effect, piezoelectric and alkaline synergistic protection is achieved, and a comprehensive solution with long-acting corrosion resistance and intelligent response is provided for a degradable magnesium alloy implantation instrument.

The application relates to a preparation method of a magnesium alloy stent composite coating and belongs to the technical field of biomedical materials. In view of the technical problem that an existing polyester coating produces acid by degradation, and accelerates corrosion of a magnesium alloy stent, a composite coating with piezoelectric-pH synergistic protection function is provided. The coating comprises a PVDF-g-APTES primer layer, a pH regulating intermediate layer composed of PVDF, PDLLA and alkaline nanoparticles, and a drug-loaded PDLLA outer coating. The application actively increases the interface pH to the passivation zone by on-demand release of alkaline nanoparticles, and realizes the positive feedback mechanism of "the more stress, the more protection" by using the piezoelectric effect. Compared with the prior art, the dynamic corrosion resistance of the application is increased by more than 40%, the synergistic effect makes the protection effect increased by more than 60%, the piezoelectricity and alkalinity are synergistically protected, a long-acting corrosion-resistant and intelligent response comprehensive solution is provided for the degradable magnesium alloy implant device.