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Preparation method of valienamine using solid catalysts

A technology of solid catalyst, Jinggang mycylamine, applied in the field of using solid catalyst to prepare Jinggangmycylamine, which can solve problems such as production difficulties

Inactive Publication Date: 2007-11-07
B T GIN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, production according to this method is difficult in its current state due to some technical problems such as gene expression and the degree of activity of the probe genes

Method used

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  • Preparation method of valienamine using solid catalysts
  • Preparation method of valienamine using solid catalysts
  • Preparation method of valienamine using solid catalysts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]Embodiment 1: Utilize the method for cation exchange resin to produce Jinggang mycylamine

[0041] Add 1 g of pure acarbose derivatives (disaccharides and / or trisaccharides) (Zhejiang, Dongli, China) into a high-pressure reactor with a volume of 100 ml, and then sequentially add 20 ml of water (for dissolving acarbose) into it. wave sugar derivative), and 2 g of a strong acid cation exchange resin, Amberlyst 131 (registered trademark of Rohm & Hass Co.), and the resulting mixture was reacted at 80° C. for 12 hours or more, and the reaction solution was removed by filtration. Add 100ml of 0.5N ammonia water to the filtered cation exchange resin and stir for 30 minutes, then filter the mixture, and purify the filtrate by weak acid cation exchange resin to obtain 0.23g mycamine.

Embodiment 2

[0042] Embodiment 2: the method utilizing zeolite to produce Jinggang mycylamine

[0043] Add 1 g of pure acarbose derivatives (disaccharides and / or trisaccharides) (Zhejiang, Dongli, China) into a high-pressure reactor with a volume of 100 ml, and then sequentially add 20 ml of water (for dissolving acarbose) into it. wave sugar derivative), and 2 g of a strong acid zeolite-based catalyst, ZSM-5 (manufactured by UnionCarbide), and the resulting mixture was reacted at 120°C for 12 hours or more, and the reaction solution was removed by filtration. Add 100 ml of 0.5N ammonia water to the filtered zeolite-based catalyst, and stir for 30 minutes, then filter the mixture, and purify the filtrate by weak acid cation exchange resin to obtain 0.19 g of jinggangmycetamine.

Embodiment 3

[0044] Embodiment 3: Utilize the method for the production of Jinggang mycylamine by cationic exchange resin

[0045] Add 1 g of Jinggangmycin A and its derivatives (Zhejiang, Dongli, China) into a high-pressure reactor with a volume of 100 ml, then sequentially add 20 ml of water therein (for dissolving Jinggangmycin A and its derivatives), and 2 g of strong acid cation exchange resin, Amberlyst 131 (registered trademark of Rohm & Hass Co.), and then the resulting mixture was reacted at 80°C for 12 hours or more, and the reaction solution was removed by filtration. Add 100ml of 0.5N ammonia water to the filtered cation exchange resin, and stir for 30 minutes, then filter the mixture, and purify the filtrate by weak acid cation exchange resin to obtain 0.29g mycamine.

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Abstract

Disclosed is a preparation method of valienamine using solid catalysts. The valienamine, which has strong inhibiting activity, is prepared by selective hydrolysis of acarbose and acarbose derivatives, validamycin and validamycin derivatives, validamycin and validamycin derivatives, or validoxylamine and validoxylamine derivatives. In the present invention, a solid catalyst such as a strong acidic cation exchange resin, a strong basic anion exchange resin or zeolite is used.

Description

technical field [0001] The present invention relates to the method for preparing valienamine (valienamine), compared with prior art, the inventive method has the output that improves obviously, and described method is to utilize heterogeneous solid catalyst to selectively hydrolyze acarbose (acarbose) Or Jinggangmycin (validamycin) derivatives, this method is a purification technology, which can improve the environmental problems caused by waste acid, waste water, etc. produced by the traditional homogeneous liquid acid catalysis method. Background technique [0002] The traditional methods for commercial-scale production of jinggangmycin generally include the following two methods: one is to directly obtain jinggangmycin by bacterial hydrolysis of jinggangmycin, and the other is to synthesize jinggangmycin with glucose as a starting material. [0003] The Jinggangmycin derivative mainly includes a Jinggangmycin enamine moiety, and is selectively bonded with validamine or va...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C213/00C07C215/00
CPCF16K27/0209F16K31/18F16K35/06
Inventor 许栗吴振焕朴永日
Owner B T GIN INC