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Antiphlogistic gallbladder-benefiting soft capsule and its prepn process

A technology for reducing inflammation and promoting gallbladder, soft capsules, applied in the directions of capsule delivery, digestive system, medical preparations containing active ingredients, etc. Heat loss, good fluidity and fast dissolution

Active Publication Date: 2007-12-12
WUHU LUYE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But those of ordinary skill in the art know that Chinese medicine soft capsules are different from Western medicine soft capsules, and the content components of Western medicine soft capsules are relatively single and easy to make oil solution, which is easier to encapsulate, while the prescription of Chinese medicine is very complicated, and the ointment rate is large. Strong water absorption, the preparation of the contents is relatively complicated, which objectively requires that the contents of soft capsules should not only be uniform and stable, but also have good stability. Therefore, the technology of making soft capsules with good curative effect, high bioavailability and stable quality It is difficult and cannot be achieved by those of ordinary skill in the art using conventional techniques

Method used

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  • Antiphlogistic gallbladder-benefiting soft capsule and its prepn process
  • Antiphlogistic gallbladder-benefiting soft capsule and its prepn process

Examples

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Effect test

Embodiment 1

[0022] The preparation of embodiment 1 anti-inflammatory choleretic extract

[0023] Take 1736g of Andrographis paniculata and 1736g of bitter wood and heat and extract twice with 80-85% ethanol, add 8 times the amount for the first time, extract for 2 hours, add 6 times the amount for the second time, extract for 1 hour, filter, combine the filtrates, and recover under reduced pressure Ethanol, concentrated into a thick paste with a relative density of 1.25-1.28 (measured at 60°C); take 1736g of Xihuangcao and add water to decoct twice, add 10 times the amount of water for the first time, decoct for 2 hours, and add 8 times the amount for the second time Water, decoct for 1 hour, filter, combine the decoction, concentrate to a clear paste with a relative density of 1.10-1.12 (measured at 60°C), add 5 times the amount of 70% ethanol, stir well, let stand for 24 hours, filter, and decompress The ethanol is recovered, concentrated into a thick paste with a relative density of 1....

Embodiment 2

[0026] Composition: 250g of anti-inflammatory and choleretic extract; 250g of soybean salad oil, 7.5g of beeswax, 5.0g of Span-80, 200ml of water, 100g of glycerin, 200g of gelatin, 0.6g of milk chocolate brown,

[0027] Preparation process: Take the prescribed amount of anti-inflammatory and choleretic extract, crush it, sieve it through 100 mesh, and set aside; take the prescribed amount of beeswax and span, heat and melt it in a water bath at 60°C, add it to soybean salad oil, stir and mix well; mix the above extract Add the fine powder into the oil, stir and mix, adjust the fineness of the colloid mill between 5 and 15 μm, add the liquid medicine and circulate and grind for 0.5 hours, mix well, filter (through a 100-mesh sieve), and obtain the contents of the soft capsule The product: take gelatin, glycerin, distilled water, and milk chocolate brown, melt the gel to make a rubber skin, fill and seal the pressed pills, make soft capsules, dry for 12 hours, wash the pills wit...

Embodiment 3

[0029] Recipe: 250g of anti-inflammatory and choleretic extract, 380g of peanut oil, 10g of beeswax, 8010g of Span-8010g, 200ml of water, 100g of glycerin, 200g of gelatin, 0.6g of milk chocolate brown,

[0030] Preparation process: Take the prescribed amount of anti-inflammatory and choleretic extract, crush it, sieve through 100 mesh, and set aside; take the prescribed amount of beeswax and Span-80, heat and melt it in a water bath at 60°C, add it to peanut oil, stir and mix well; mix the above extract Add the fine powder into the oil, stir and mix, adjust the fineness of the colloid mill between 5 and 15 μm, add the liquid medicine and circulate and grind for 0.5 hours, mix well, filter (through a 100-mesh sieve), and obtain the contents of the soft capsule The product: take gelatin, glycerin, distilled water, and milk chocolate brown, melt the gel to make a rubber skin, fill and seal the pressed pills, make soft capsules, dry for 12 hours, wash the pills with alcohol, dry, ...

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Abstract

The present invention relates to new antiphlogistic gallbladder-benefiting medicine preparation, and is especially antiphlogistic gallbladder-benefiting soft capsule. The antiphlogistic gallbladder-benefiting soft capsule consists of medicine liquid and covering, and the medicine liquid consists of antiphlogistic gallbladder-benefiting medicine extract, diluent, suspension assistant and lubricant. The present invention has the features of fast active component leaching speed, high bioavailability, high treating effect, high medicine liquid stability, high medicine liquid flowability, etc.

Description

technical field [0001] The invention relates to a new drug preparation for reducing inflammation and promoting gallbladder, in particular to soft capsules for reducing inflammation and promoting gallbladder and its preparation process. Background technique [0002] Anti-inflammatory and gallbladder is composed of Andrographis paniculata, Xihuangcao, and bitter wood. It is mainly used for acute cholecystitis and cholangitis caused by damp-heat in the liver and gallbladder. Medicinal: Bitterwood dries dampness and promotes gallbladder as an adjuvant drug, and all medicines are used in combination to play a role in clearing away heat and detoxification, drying dampness and promoting gallbladder, and is a variety recorded in the National Pharmacopoeia. [0003] At present, the oral preparations of Xiaoyan Lidan are ordinary tablets and capsules of Xiaoyan Lidan. Since Xiaoyan Lidan is composed of a variety of traditional Chinese medicine ingredients, the active ingredients are r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/19A61K36/185A61K9/48A61P1/16
Inventor 杨荣兵
Owner WUHU LUYE PHARMA
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