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Photoacoustic blood vessel imaging method and equipment for monitoring photodynamic tumor treating effect

A technology of photodynamic therapy and vascular imaging, which is applied in the field of medicine and medical equipment, can solve the problems of low resolution, low sensitivity of pure optical imaging, and inability to realize vascular damage, etc., and achieves the effect of low cost and easy application and promotion

Inactive Publication Date: 2008-02-06
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Traditional optical microscopy technology can observe the blood vessels around the tumor, but tissue slices are required, and the carrier cannot detect the damage of blood vessels in real time; the use of laser imaging technology can study the blood flow velocity distribution, perfusion rate and other hemodynamic changes
However, since tissue is a turbid medium, strong scattering of light will result in low sensitivity and low resolution of purely optical imaging

Method used

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  • Photoacoustic blood vessel imaging method and equipment for monitoring photodynamic tumor treating effect
  • Photoacoustic blood vessel imaging method and equipment for monitoring photodynamic tumor treating effect

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Embodiment 1

[0040] It can be seen from Fig. 1 that the device of the present invention is composed of a laser generating component 1, a rotating scanning component 2, an acoustic signal collecting component 3, a computer component 4, a sample fixing component 5, and an acoustic coupling component 6. The laser component 1 is composed of a laser 1-1, a coated mirror 1-2, a concave lens 1-3, and a ground glass 1-4 connected in sequence; the rotating scanning component is composed of a computer 4 through a digital I / O card and a relay controller 2- 2 Control the stepping motor 2-1 to drive the rotating bracket 2-3 to rotate. The acoustic signal acquisition component is amplified by the acoustic detector 3-1 by the signal amplifier 3-2, and the oscilloscope 3-3 is averaged and collected by the computer 4 with a GPIB card through the control software. Among them: the laser 1-1 uses the TII of Belarusian LOTIS company, which can emit continuously adjustable wavelengths of 350-500nm, 690nm-1000nm, an...

Embodiment 2

[0046] The device used in this embodiment is the same as that in embodiment 1. The above-mentioned device is applied to the study of the damage effect of photodynamic force on different blood vessel diameters, light dose and photosensitizer concentration. In the experiment, the photodynamic data of blood vessels with a diameter of about 80μm and a diameter of 284μm were analyzed respectively. The damage to the blood vessel is shown in Figure 4(a) and (b). Among them, when the concentration of ProtoporphyrinIX is 40μmol / L, the light dose is 36J / cm 2 , 72J / cm 2 Blood vessels with a diameter of about 80μm are almost completely destroyed. Blood vessels with a diameter of 284μm are not affected by a small dose (20μmol / L of ProtoporphyrinIX) due to its thicker walls. They are all above 50% of the initial value and will be compared after 24h. More recovery, high-dose (40μmol / L) ProtoporphyrinIX damages blood vessels, but the damage is still much smaller than that of blood vessels with a ...

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Abstract

The present invention relates to real-time monitoring of photodynamic tumor treating effect, and the photoacoustic blood vessel imaging method is that during laser irradiation of tumor tissue for photodynamic treatment, the photoacoustic chromatographic images of the tumor tissue before and after photodynamic action are compared and the blood vessel diameter change is reflected with the positive and negative peak-to-peak width of the photoacoustic blood vessel signals. The equipment for the real-time monitoring of photodynamic tumor treating effect includes laser generator assembly, acoustic signal acquiring assembly and computer successively connected electrically, as well as rotating scan mechanism connected electrically to the computer, sample fixing assembly and connected acoustic assembly. The present invention is sensitive and quick in real-time monitoring of photodynamic tumor treating effect.

Description

Technical field [0001] The present invention relates to medicine and medical equipment. In more detail, it is a method of photoacoustic vascular imaging to monitor the effect of tumor photodynamic therapy. [0002] The present invention also relates to a device for implementing the above method. Background technique [0003] Photodynamic therapy is the treatment of early malignant tumors with minimal damage, and it is also a palliative treatment for advanced malignancies. Photodynamic therapy can selectively eliminate local superficial tumors without jeopardizing normal tissues, and can be performed in conjunction with chemotherapy and radiotherapy. Because the survival and growth of tumor cells mainly rely on the blood vessels surrounding the tumor to provide nutrients, the vascular damage effect is considered to be one of the important mechanisms for photodynamic therapy of tumors. Therefore, the monitoring and research of vascular damage effects in tumor photodynamic therapy h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B18/20A61B8/00A61N5/067G06T1/00G06T7/00
Inventor 邢达向良忠
Owner SOUTH CHINA NORMAL UNIVERSITY
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