Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine

A technology of ursane-type and triterpene saponins, which is applied in the field of compounds and can solve problems such as increasing the activity of human white blood cells and platelets

Inactive Publication Date: 2008-02-06
CHENGDU DIAO PHARMA GROUP
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no relevant literature records or research reports about ursane-type triterpene saponins and their derivatives that can increase the activity of human leukocytes and platelets.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine
  • Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine
  • Application of ursane type triterpenoid saponin in the preparing process of leucocyte and/or platelet increasing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Extraction, separation and structure confirmation of ursane-type triterpene saponins A, B, C

[0033] Extraction and separation: Sanguisorba officinalis L. was purchased from Chengdu Traditional Chinese Medicine Company. Take 20kg of Sanguisorba medicinal material, slice it, extract twice with 8 times 70% ethanol, filter for 1 hour each time, recover the ethanol, add water to 0.3g crude drug / ml, refrigerate for 12 hours, take the supernatant and absorb through the macropores Resin. First wash with water until the Molish reaction is negative, then eluted with 70% ethanol, collect the eluate, recover the ethanol, and concentrate to obtain a concentrated extract. Add 25L of hot water to the concentrated extract and stir thoroughly, and then suction and filter out the precipitate (about 4kg, mainly tannin detected by TLC). The filtrate was extracted three times with equal volumes of ethyl acetate and n-butanol, and then concentrated under reduced pressure and evapora...

Embodiment 2

[0038] Example 2: Therapeutic effects of ursane-type triterpene saponins A, B, C, D, E, F, G, H on leukopenia and thrombocytopenia induced by cyclophosphamide in mice

[0039] Materials and Methods

[0040] Test drug: The three samples of compound A, B, and C are all off-white powders or broken crystals, prepared according to the method of Example 1, and can also be separated, identified and prepared with reference to the literature [Triterpene glycosides from the roots Sanguisorba officindis, Phytochenistry, 57(5), 773-779, 2001]; Compound D, E, F refer to literature [Triterpene glycosides from the roots Sanguisorbaofficindis, Phytochenistry, 57(5), 773-779, 2001] method of separation, identification and preparation. Compound G was isolated, identified and prepared with reference to the literature [phytochemistry, 26(7), 2023, 1987; Chen.pharm. Bull. 35(2), 524, 1987]. Compound H was isolated, identified and prepared with reference to the literature [phytochemistry, 21(6), 1373, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the use of ursane type triterpenoid saponin in preparing medicine for increasing leucocyte and / or platelet which has a general formula (I), the invention also provides a pharmaceutical composition having the action of increasing human leucocyte and / or platelet, which contains ursane type triterpenoid saponin composition having a general formula (I), and pharmaceutically acceptable salts.

Description

Technical field: [0001] The present invention relates to a new use of a compound. Specifically, the present invention relates to the use of a ursane-type triterpene saponin compound in the preparation of a medicine for preventing or treating human leukopenia and (or) thrombocytopenia. Background technique: [0002] Human leukopenia is a common clinical disease and frequently-occurring disease. Under normal circumstances, chronic leukopenia has no special symptoms, but some patients may experience mild fatigue, dizziness, low-grade fever, and oral ulcers. In severe cases of leukopenia, various infections can occur, such as respiratory infections, bronchitis, pneumonia, otitis media and urinary system infections. There are many factors that cause leukopenia, and the common ones include the following: First, leukopenia caused by various therapeutic drugs, such as tumor chemotherapy drugs, antipyretic analgesics, sulfa drugs, antithyroid drugs, and antiallergic drugs. May cause the r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/739A61P7/00
Inventor 邹文俊刘忠荣李伯刚付铁军黄瑜丁立生彭树林
Owner CHENGDU DIAO PHARMA GROUP