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Method for dreging microchannel of glass microflow control chip

A microchannel and glass microtechnology, applied in the field of removing blockage of glass microfluidic chips microchannels, can solve the problems of high requirements for solutions and samples, blockage of microchannels, and high cost, achieve research and application promotion, expand application scope, use Life extension effect

Inactive Publication Date: 2008-05-07
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The processing cost of glass chips is high. The unit price of general-purpose glass microfluidic chips processed by the University of Alberta in Canada is more than 200 US dollars. If you design and process special-purpose chips, the cost will be higher
Once the microchannel is blocked, the whole chip can only be scrapped
In order to avoid clogging of microchannels, the operation of glass chips is often carried out in ultra-clean rooms, and the requirements for solutions and samples are high, so the application is limited

Method used

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  • Method for dreging microchannel of glass microflow control chip
  • Method for dreging microchannel of glass microflow control chip
  • Method for dreging microchannel of glass microflow control chip

Examples

Experimental program
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Effect test

Embodiment 1

[0012] 1. figure 1 It is the flocculent clogging of the microchannels of a general-purpose glass microfluidic chip observed under a microscope. It is difficult to push or suck it out with air flow or liquid flow, and it cannot be dissolved, which often leads to the scrapping of the entire chip. Take a 200μL conical plastic tip, cut off a section of its tip so that it can be inserted tightly into the small groove of the chip, and install the tip-cut tip on a plastic syringe for introducing and withdrawing liquid ; Be installed at the outlet of the gas pipeline of a high-pressure nitrogen cylinder with a pressure reducing valve, and purge the chip with a nitrogen pressure of 2 atmospheres.

[0013] 2. Rinse the small groove and surface of the microfluidic chip with a plastic washing bottle filled with distilled water, and dry the surface of the chip and the microchannel with nitrogen.

[0014] 3. Inject 1mol / L NaOH to soak the microchannel of the chip for 10min, blow dry with n...

Embodiment 2

[0020] A general-purpose glass microfluidic chip processed by the University of Alberta in Canada is used to check all microchannels under a microscope to confirm that there is no blockage in the microchannels. Place the chip horizontally, scrape off a little debris from the surface of the plastic tip with a blade, mix it with about the same amount of lime powder, pour it into the small groove of the glass microfluidic chip, and then add 2 drops of tap water into the small groove. Rinse the small groove and surface of the chip with a plastic washing bottle filled with distilled water, and blow dry the surface of the chip and the microchannel with nitrogen. Observed under a microscope, it can be seen that dust and dust form a blockage in the microchannel of the chip. Inject 1.5mol / L NaOH to soak the microchannel of the chip for 8 minutes, blow dry with nitrogen and then clean the microchannel with distilled water; dry the microchannel with nitrogen, inject 1.5mol / L HCl and soak...

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Abstract

A method for eliminating micro-channel blind of glass micro-flow control chip is carried out by pouring mixed liquid of concentrated sulfuric acid and H2O2 with volume ratio=3-4:1 into micro-channel of glass micro-flow control chip, heating glass micro-flow control chip blockage until boiling the mixed liquid and cooling. It has long life and extended application.

Description

technical field [0001] The invention relates to a method for removing clogging of a microchannel of a glass microfluidic chip. Background technique [0002] The micro-total analysis system has developed rapidly in recent years and is one of the most active research fields at present. It aims to integrate the main functions of the analysis laboratory into a microfluidic chip to meet the analysis needs of various industries. The materials used to make microfluidic chips include silicon, glass, polymers, etc. Among them, glass has good electroosmotic properties and excellent optical properties, which is suitable for high-precision processing and has been widely used to make microfluidic chips. The processing cost of glass chips is high. The general-purpose glass microfluidic chips processed by the University of Alberta in Canada cost more than 200 US dollars. If you design and process special-purpose chips, the cost will be even higher. Once the microchannel is blocked, the en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C23/00
Inventor 陈荣生程寒程介克
Owner WUHAN UNIV