Bacteriostatic porous polyelectrolyte material and its preparation process

A polyelectrolyte, porous material technology, applied in medical science, bandages, absorbent pads, etc., can solve problems such as limited application, and achieve the effects of short hemostasis time, high water absorption, and large pore size

Inactive Publication Date: 2008-08-20
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the toxicity of glutaraldehyde, a commonly used cross-linking agent for chitosan sponges, directly limits its application in biomedicine.

Method used

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  • Bacteriostatic porous polyelectrolyte material and its preparation process
  • Bacteriostatic porous polyelectrolyte material and its preparation process
  • Bacteriostatic porous polyelectrolyte material and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A kind of preparation method of polyelectrolyte porous material, comprises the following steps: 1). First chitosan is dissolved in 1% acetic acid aqueous solution and obtains the chitosan solution of 2wt% (weight percent concentration), 2). Then it presses 1:3 weight ratio and 2wt% (weight percentage concentration) sodium alginate solution are mixed to obtain a chitosan / sodium alginate mixed solution, fully stirred to obtain a polyelectrolyte complex, homogenized and poured into a mold for freeze-drying; 3). Then the freeze-dried polyelectrolyte complexes in the mold were sequentially placed in CaCl 2 Soak in NaOH solution, wash with distilled water, and freeze-dry in a mold again to obtain an antibacterial polyelectrolyte porous material (chitosan / sodium alginate porous material), labeled as CSAL13. The results of the pore structure, water absorption rate and hemostasis time are shown in Figure 1-4 , figure 2 and Table 1.

Embodiment 2

[0016] The preparation method is the same as in Example 1, except that the mixing ratio of the chitosan solution and the sodium alginate solution is changed to 1:1 and 3:1, and the obtained products are labeled as CSAL11 and CSAL31 respectively. The results of the pore structure, water absorption rate and hemostasis time are shown in Figure 1-3 , Figure 1-2 , figure 2 and Table 1.

Embodiment 3

[0018] 1), a preparation method of antibacterial polyelectrolyte porous material, comprises the following steps: 1). First chitosan is dissolved in 1% acetic acid aqueous solution to obtain 2wt% chitosan solution, 2). Then it is pressed 1: 3 weight ratio is mixed with 2wt% sodium alginate solution to obtain chitosan / sodium alginate mixed solution, and sulfadiazine silver bacteriostatic agent is dispersed in chitosan / sodium alginate mixed solution, and its addition accounts for mixed solution 7% of the dry weight of the substance (that is, the weight of chitosan and sodium alginate), fully stirred to obtain the polyelectrolyte complex, homogenized and then poured into the mold for freeze-drying; 3). Then the polyelectrolyte after freeze-drying in the mold complex in turn in CaCl 2 After immersing in NaOH solution, wash with distilled water, freeze-dry in the mold again, obtain antibacterial polyelectrolyte porous material (porous material loaded with sulfadiazine silver), and t...

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Abstract

One kind of porous bacteriostatic polyelectrolyte material suitable for stopping bleeding and dressing wound is disclosed. The material features that it is prepared with chitosan solution in 1-5 wt% concentration and sodium alginate solution 1-5 wt% concentration in the weight ratio of 0.25-4 as material and through mixing and freeze drying. The chitosan solution is prepared through dissolving chitosan in water solution of acetic acid. The material includes also sulfadizine silver or PVP-iodine bacteriostatic agent in the amount of 3-10 wt% of chitosan and sodium alginate. The porous material has no toxicity, relatively great pores, high water absorption rate and short bleeding stopping period.

Description

technical field [0001] The invention relates to a preparation method of a porous material suitable for hemostasis and wound dressing. Background technique [0002] In recent years, sponges have been widely used in the fields of sustained drug release, wound dressing, cell culture, and tissue engineering. The development of biomedical sponges and porous materials using natural biopolymers has become a research hotspot. Chitosan is a polycationic polysaccharide whose basic structural unit is β-(1→4)-2-amino-2-deoxy-D-glucan. Chitosan has good bioactivity and biocompatibility. Studies have shown that it also has the effect of promoting wound healing and hemostasis. Therefore, the research and application in artificial skin, hemostatic materials and wound dressing materials are attracting attention. Alginic acid is extracted from brown algae and is a polyanionic heteropolysaccharide composed of β-(1→4)-D-mannuronic acid and α-(1→4)-L-guluronic acid. Sodium alginate is the sodi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/46
Inventor 樊李红黄进徐咏梅郑化
Owner WUHAN UNIV OF TECH
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