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Prepn process of double-layer catechin microcapsule

A technology of catechins and microcapsules, applied in the directions of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of difficulty in large-scale popularization and application, low microencapsulation efficiency, etc., and achieves good stability and high microencapsulation efficiency. , the effect of low production cost

Inactive Publication Date: 2008-09-17
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Catechin is a highly water-soluble substance. At present, scholars at home and abroad have also conducted research on its microencapsulation, but all of them have the defect of low microencapsulation efficiency, which makes it difficult to promote large-scale industrialization and application.

Method used

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  • Prepn process of double-layer catechin microcapsule

Examples

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Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Dissolve 100 grams of catechin in 200 mL of distilled water, heat to 80 degrees Celsius, add 3 grams of octadecanoic acid, and fully emulsify in an emulsifier at 3800 rpm for 0.2 hours; then prepare 300 grams of 3% by weight Chitosan acetic acid solution, then the capsule core is slowly added in the chitosan acetic acid solution, fully homogenized for 0.5 hour to form an O / W type microemulsion, and then this microemulsion is spray-dried to obtain chitosan as Matrix of catechin microspheres. The spray conditions are:

[0012] Inlet temperature 152°C Outlet temperature 78°C

[0013] Feed rate 5mL / min Air inlet pressure 0.38Mpa

[0014] Dissolve 15 grams of sodium alginate in 485 grams of carbon tetrachloride to make 500 grams of sodium alginate carbon tetrachloride solution with a weight ratio of 3%. Add it into the 3% sodium alginate carbon tetrachloride solution, stir to make it evenly dispersed in the sodium alginate solution, and fully stir at 800 rpm fo...

Embodiment 2

[0015] Example 2: Dissolve 100 grams of catechin in 200 mL of distilled water, heat to 80 degrees Celsius, add 6 grams of palmitic acid, and fully emulsify in an emulsifier at 3800 rpm for 0.2 hours; then prepare 300 grams of 3% by weight Chitosan acetic acid solution (preparation method is the same as embodiment 1), capsule heart is slowly added in this chitosan acetic acid solution, fully homogeneous 0.5 hour makes it form O / W type microemulsion, then this microemulsion is carried out Spray drying to obtain catechin microspheres with chitosan as the matrix. The spray conditions are:

[0016] Inlet temperature 152°C Outlet temperature 78°C

[0017] Feed rate 5mL / min Air inlet pressure 0.38Mpa

[0018] Dissolve 15 grams of sodium alginate in 485 grams of carbon tetrachloride to make 500 grams of sodium alginate carbon tetrachloride solution with a weight ratio of 3%. Add it into the 3% sodium alginate carbon tetrachloride solution, stir to make it evenly dispersed in the so...

Embodiment 3

[0022] Example 3: Dissolve 100 grams of catechin in 200 mL of distilled water, heat to 80 degrees Celsius, add 4 grams of palmitic acid, and fully emulsify in an emulsifier at 3800 rpm for 0.2 hours; then prepare 300 grams of 3% by weight Sodium alginate carbon tetrachloride solution (preparation method is the same as in Example 1), then the capsule core is slowly added to the sodium alginate carbon tetrachloride solution, fully homogenized for 0.5 hours to form O / W / O microemulsion body, and then the microemulsion was spray-dried to obtain catechin microspheres based on sodium alginate. The spray conditions are:

[0023] Inlet temperature 152°C Outlet temperature 78°C

[0024] Feed rate 5mL / min Air inlet pressure 0.38Mpa

[0025] Dissolve 15 grams of polychitosan in 485 grams of acetic acid solution to make 500 grams of chitosan acetic acid solution with a weight ratio of 3%, and add all the catechin microspheres with the above-mentioned sodium alginate as a matrix to prepar...

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Abstract

The present invention discloses the preparation process of double-layer catechin microcapsule. The present invention treats catechin first with stearic acid and then prepares doubled-layer chitosan-sodium alginate catechin microcapsule with the stearic acid catechin as encapsulant for absorption in small intestine. The preparation process has high yield and the prepared double-layer catechin microcapsule has high efficiency, high stability and high antioxidant activity, and may be absorbed in small intestine in slow release mode.

Description

technical field [0001] The invention relates to a preparation technology of catechin microcapsules, in particular to a catechin double-layer microcapsule which can be absorbed through the small intestine in a sustained release form. Background technique [0002] Catechin is an active ingredient in tea, which has a strong antioxidant effect. Although it has not been widely used clinically, its broad application prospect is beyond doubt. Current research has found that the antioxidant capacity of catechin is much stronger than antioxidants such as VitE and VitC. In the early 1990s, Jia Zhishen et al. used the riboflavin light system to produce , found that adding 20-200mg / L catechins It has obvious clearing effect. Wang et al. have used H 2 o 2 -Fe 2+ The system induced lipid peroxidation in rabbit liver homogenate, and the content of lipid peroxidation product malondialdehyde (MDA) was determined by thiobarbituric acid (TBA) method, which was directly confirmed by ele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61K9/50A61P39/06
Inventor 何小解易著文
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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