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Topical anti-inflammatory compositions and methods of reducing inflammation

A topical composition, technology of licorice extract, applied in anti-inflammatory agents, drug combinations, pharmaceutical formulas, etc., can solve problems such as side effects, abnormal growth of fetal cells, etc.

Inactive Publication Date: 2008-10-01
ACCESS BUSINESS GRP INT LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Topical corticosteroids have also been used as an alternative to NSAIDs, but such steroid therapy, especially when used chronically, can also cause a range of serious side effects, including teratogenic growth of cells in the developing fetus

Method used

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  • Topical anti-inflammatory compositions and methods of reducing inflammation
  • Topical anti-inflammatory compositions and methods of reducing inflammation
  • Topical anti-inflammatory compositions and methods of reducing inflammation

Examples

Experimental program
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Embodiment

[0035] Compositions of the invention comprising a combination of linseed extract and licorice extract were evaluated for their anti-inflammatory potential as described herein. The release of PGE2 and GM-CSF from skin tissue provides a measure of the likelihood of protection after preincubation with the test substance, whereas MTT (3-[4,5-dimethylthiazol-2yl]-2,5- The reduction of biphenyl-2H-tetrazolium bromide) provides an estimate of the potential for toxicity.

[0036] The skin tissue used in this study, TESTSKIN II (Organogenesis Inc., Canton, MA) was constructed from human skin with anatomical structure and physiological functions that stimulate actual living skin. This tissue has an upper epidermal layer with well-differentiated keratinocytes and stratum corneum and a lower dermal layer with viable fibroblasts capable of producing a collagen matrix.

[0037] The composition of the test substances for this study is summarized in Table 1 below. The identified test substa...

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PUM

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Abstract

The invention describes topical anti-inflammatory compositions that include effective amounts of a linseed extract and a licorice extract. In addition, methods of reducing inflammation are described, which include applying topically to a site of inflammation an effective amount of a composition comprising a linseed extract and a licorice extract.

Description

technical field [0001] The present invention relates to anti-inflammatory compositions, and in particular to topical anti-inflammatory compositions. The compositions of the invention have particular utility as cosmetic and / or dermopharmaceutical compositions. Background technique [0002] Human skin is susceptible to numerous environmental and other conditions. Some of these environmental conditions, such as sun exposure, are irritating to the skin. In addition, the application of exfoliants such as hydroxy acids and other cosmetic compositions used to reduce skin texture and wrinkles frequently irritates the skin. Accordingly, it would be useful to provide topical anti-inflammatory compositions to overcome these and other skin irritations. [0003] One solution is the use of non-steroidal anti-inflammatory drugs, commonly known as NSAIDs. Despite their widespread use, the therapeutic usefulness of NSAIDs is offset by a range of side effects, including potentially life-t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K36/484A61K36/55A61P17/00A61P29/00A61Q19/00A61K8/63
CPCA61Q19/00A61K36/484A61K8/63A61K2800/75A61K36/55A61K8/97A61K8/9789A61P17/00A61P29/00A61K2300/00
Inventor J·R·迈恩H·罗-施密德特
Owner ACCESS BUSINESS GRP INT LLC
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