Gatiflxacin eye gels based on HPMC medium and its preparing method

A technology of gatifloxacin and gel, which is applied in the field of medicine, can solve the problems that patients are not willing to use, low bioavailability, poor compliance, etc., and achieve effective drug concentration maintenance, long residence time, and good compatibility Effect

A technology of gatifloxacin and gel, which is applied in the field of medicine, can solve the problems that patients are not willing to use, low bioavailability, poor compliance, etc., and achieve effective drug concentration maintenance, long residence time, and good compatibility Effect

CN100427091CInactive Publication Date: 2008-10-22SHENYANG PHARMA UNIVERSITY
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Get 39kg of deionized water, add gatifloxacin 0.15kg, stir to dissolve. Take 1 kg of hydroxypropyl methylcellulose and sprinkle it into the above solution. After standing overnight, add 0.005 kg of benzalkonium bromide, 0.4 kg of sodium chloride, and 2 kg of hydroxypropyl-β-cyclodextrin, and stir to dissolve. Use 10% NaOH solution to adjust the pH to 7.4, pass the solution through a 0.22um microporous membrane, and add water from the filter to a total of 50kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

Embodiment 2

[0028] Get 39kg of deionized water, add gatifloxacin 0.15kg, stir to dissolve. Take 4kg of hydroxypropyl methylcellulose and sprinkle it into the above solution. After standing overnight, add 0.005 kg of benzalkonium bromide, 0.4 kg of sodium chloride, and 2 kg of hydroxypropyl-β-cyclodextrin, and stir to dissolve. Adjust the pH to 7 with boric acid, pass the solution through a 0.22um microporous membrane, and add water from the filter to a total of 50kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

Embodiment 3

[0030] Get 39kg of deionized water, add gatifloxacin 0.15kg, stir to dissolve. Take 1kg of methylcellulose and sprinkle it into the above solution. After standing overnight, add 0.005 kg of benzalkonium bromide, 0.4 kg of sodium chloride, and 2 kg of hydroxypropyl-β-cyclodextrin, and stir to dissolve. Adjust the pH to 7 with 10% NaOH solution, pass the solution through a 0.22um microporous membrane, and add water from the filter to a total of 50kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

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PUM

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Abstract

An ocular Jiatishaxing gel for treating eyelid inflammation, stye, conjunctivitis, dacryocystitis, keratitis, corneal ulcer and trachoma is prepared from Jiatishaxing, HPMC as matrix, antiseptic, isotonic regulator, osmotic promoter, pH regulator and water through dissolving Jiatishaxing in water, adding others, stirring, regulating pH=5-9, filter and adding water.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to a gatifloxacin ophthalmic gel with HPMC as a matrix and a preparation method thereof. Background technique: [0002] According to statistics, more than 80% of the patients who go to see a doctor in ophthalmology are ocular infection. Ophthalmic infections include conjunctivitis, keratitis, and global inflammation; divided from pathogenic bacteria, including bacterial infections and fungal infections. Anti-infective drugs can be used for bacterial infection, but due to the existence of the blood-ocular barrier, the drugs cannot fully penetrate into the eye, and the drug concentration in the intraocular tissue is low. Therefore, the anti-infective drugs used in ophthalmology are those with good permeability, such as tobramycin, cleomycin, and chloramphenicol. In recent years, the application of quinolones in ophthalmology has grown rapidly, such as ofloxacin, levofloxacin, norflo...

Claims

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Application Information

Patent Timeline
22 Oct 2008
Publication
CN100427091C
IPC
A61K31/496; A61K9/00; A61K47/30; A61K47/38; A61P27/02
Inventors
潘卫三; 刘志东